Search Results - "Bráz, Joao M"

Restriction of transient receptor potential vanilloid-1 to the peptidergic subset of primary afferent neurons follows its developmental downregulation in nonpeptidergic neurons by Cavanaugh, Daniel J, Chesler, Alexander T, Bráz, Joao M, Shah, Nirao M, Julius, David, Basbaum, Allan I

“…Primary afferent "pain" fibers (nociceptors) are divided into subclasses based on distinct molecular and anatomical features, and these classes mediate noxious…”
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Functional Synaptic Integration of Forebrain GABAergic Precursors into the Adult Spinal Cord by Etlin, Alex, Bráz, Joao M, Kuhn, Julia A, Wang, Xidao, Hamel, Katherine A, Llewellyn-Smith, Ida J, Basbaum, Allan I

“…Spinal cord transplants of embryonic cortical GABAergic progenitor cells derived from the medial ganglionic eminence (MGE) can reverse mechanical…”
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Identification of multisegmental nociceptive afferents that modulate locomotor circuits in the neonatal mouse spinal cord by Mandadi, Sravan, Hong, Peter, Tran, Michelle A., Bráz, Joao M., Colarusso, Pina, Basbaum, Allan I., Whelan, Patrick J.

“…ABSTRACT Compared to proprioceptive afferent collateral projections, less is known about the anatomical, neurochemical, and functional basis of nociceptive…”
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Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain by Yu, Xiaobing, Liu, Hongju, Hamel, Katherine A., Morvan, Maelig G., Yu, Stephen, Leff, Jacqueline, Guan, Zhonghui, Braz, Joao M., Basbaum, Allan I.

“…Paralleling the activation of dorsal horn microglia after peripheral nerve injury is a significant expansion and proliferation of macrophages around injured…”
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Forebrain GABAergic Neuron Precursors Integrate into Adult Spinal Cord and Reduce Injury-Induced Neuropathic Pain by Bráz, João M., Sharif-Naeini, Reza, Vogt, Daniel, Kriegstein, Arnold, Alvarez-Buylla, Arturo, Rubenstein, John L., Basbaum, Allan I.

“…Neuropathic pain is a chronic debilitating disease characterized by mechanical allodynia and spontaneous pain. Because symptoms are often unresponsive to…”
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Microcircuit Mechanisms through which Mediodorsal Thalamic Input to Anterior Cingulate Cortex Exacerbates Pain-Related Aversion by Meda, Karuna S., Patel, Tosha, Braz, Joao M., Malik, Ruchi, Turner, Marc L., Seifikar, Helia, Basbaum, Allan I., Sohal, Vikaas S.

“…Hyperexcitability of the anterior cingulate cortex (ACC) is thought to drive aversion associated with chronic neuropathic pain. Here, we studied the…”
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Dorsal Horn Parvalbumin Neurons Are Gate-Keepers of Touch-Evoked Pain after Nerve Injury by Petitjean, Hugues, Pawlowski, Sophie Anne, Fraine, Steven Li, Sharif, Behrang, Hamad, Doulia, Fatima, Tarheen, Berg, Jim, Brown, Claire M., Jan, Lily-Yeh, Ribeiro-da-Silva, Alfredo, Braz, Joao M., Basbaum, Allan I., Sharif-Naeini, Reza

“…Neuropathic pain is a chronic debilitating disease that results from nerve damage, persists long after the injury has subsided, and is characterized by…”
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Structures of the σ2 receptor enable docking for bioactive ligand discovery by Alon, Assaf, Lyu, Jiankun, Braz, Joao M., Tummino, Tia A., Craik, Veronica, O’Meara, Matthew J., Webb, Chase M., Radchenko, Dmytro S., Moroz, Yurii S., Huang, Xi-Ping, Liu, Yongfeng, Roth, Bryan L., Irwin, John J., Basbaum, Allan I., Shoichet, Brian K., Kruse, Andrew C.

“…The σ 2 receptor has attracted intense interest in cancer imaging 1 , psychiatric disease 2 , neuropathic pain 3 – 5 and other areas of biology 6 , 7 . Here we…”
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Pain and itch processing by subpopulations of molecularly diverse spinal and trigeminal projection neurons by Wercberger, Racheli, Braz, Joao M., Weinrich, Jarret A., Basbaum, Allan I.

“…A remarkable molecular and functional heterogeneity of the primary sensory neurons and dorsal horn interneurons transmits pain- and or itch-relevant…”
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Transplant-mediated enhancement of spinal cord GABAergic inhibition reverses paclitaxel-induced mechanical and heat hypersensitivity by Bráz, João M., Wang, Xidao, Guan, Zhonghui, Rubenstein, John L., Basbaum, Allan I.

“…Decreased spinal cord GABAergic inhibition is a major contributor to the persistent neuropathic pain that can follow peripheral nerve injury. Recently, we…”
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GABAergic cell transplants in the anterior cingulate cortex reduce neuropathic pain aversiveness by Juarez-Salinas, Dina L, Braz, Joao M, Etlin, Alexander, Gee, Steven, Sohal, Vikaas, Basbaum, Allan I

“…Dysfunction of inhibitory circuits in the rostral anterior cingulate cortex underlies the affective (aversive), but not the sensory-discriminative features…”
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Cell transplants to treat the “disease” of neuropathic pain and itch by Basbaum, Allan I., Bráz, João M.

“…Among many mechanisms implicated in the development of neuropathic pain after nerve damage is a profound dysfunction of GABAergic inhibitory controls,…”
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TRPV1 drugs alter core body temperature via central projections of primary afferent sensory neurons by Yue, Wendy Wing Sze, Yuan, Lin, Braz, Joao M, Basbaum, Allan I, Julius, David

“…TRPV1, a capsaicin- and heat-activated ion channel, is expressed by peripheral nociceptors and has been implicated in various inflammatory and neuropathic pain…”
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Docking for EP4R antagonists active against inflammatory pain by Gahbauer, Stefan, DeLeon, Chelsea, Braz, Joao M., Craik, Veronica, Kang, Hye Jin, Wan, Xiaobo, Huang, Xi-Ping, Billesbølle, Christian B., Liu, Yongfeng, Che, Tao, Deshpande, Ishan, Jewell, Madison, Fink, Elissa A., Kondratov, Ivan S., Moroz, Yurii S., Irwin, John J., Basbaum, Allan I., Roth, Bryan L., Shoichet, Brian K.

“…The lipid prostaglandin E 2 (PGE 2 ) mediates inflammatory pain by activating G protein-coupled receptors, including the prostaglandin E2 receptor 4 (EP4R)…”
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Synergistic antipruritic effects of gamma aminobutyric acid A and B agonists in a mouse model of atopic dermatitis by Cevikbas, Ferda, Braz, Joao M., Wang, Xidao, Solorzano, Carlos, Sulk, Mathias, Buhl, Timo, Steinhoff, Martin, Basbaum, Allan I.

“…Despite recent insights into the pathophysiology of acute and chronic itch, chronic itch remains an often intractable condition. Among major contributors to…”
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Transplant restoration of spinal cord inhibitory controls ameliorates neuropathic itch by Braz, Joao M, Juarez-Salinas, Dina, Ross, Sarah E, Basbaum, Allan I

“…The transmission of pruritoceptive (itch) messages involves specific neural circuits within the spinal cord that are distinct from those that transmit pain…”
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Parallel “Pain” Pathways Arise from Subpopulations of Primary Afferent Nociceptor by Braz, Joao M., Nassar, Mohammed A., Wood, John N., Basbaum, Allan I.

“…A major unanswered question concerning “pain” circuitry is the extent to which different populations of primary afferent nociceptor engage the same or…”
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Contribution of dorsal horn CGRP-expressing interneurons to mechanical sensitivity by Löken, Line S, Braz, Joao M, Etlin, Alexander, Sadeghi, Mahsa, Bernstein, Mollie, Jewell, Madison, Steyert, Marilyn, Kuhn, Julia, Hamel, Katherine, Llewellyn-Smith, Ida J, Basbaum, Allan

“…Primary sensory neurons are generally considered the only source of dorsal horn calcitonin gene-related peptide (CGRP), a neuropeptide critical to the…”
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Presynaptic Inputs to Any CNS Projection Neuron Identified by Dual Recombinant Virus Infection by Bráz, João M, Wang, Fan, Basbaum, Allan I

“…Although neuroanatomical tracing studies have defined the origin and targets of major projection neurons (PN) of the central nervous system (CNS), there is…”
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Pain relief by supraspinal gabapentin requires descending noradrenergic inhibitory controls by Juarez-Salinas, Dina L., Braz, Joao M., Hamel, Katherine A., Basbaum, Allan I.

“…Gabapentin regulates pain processing by direct action on primary afferent nociceptors and dorsal horn nociresponsive neurons. Through an action at supraspinal…”
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