Search Results - "Brás, C."

Alpha-Synuclein: Mechanisms of Release and Pathology Progression in Synucleinopathies by Brás, Inês C, Outeiro, Tiago F

“…The accumulation of misfolded alpha-synuclein (aSyn) throughout the brain, as Lewy pathology, is a phenomenon central to Parkinson's disease (PD) pathogenesis…”
Get full text

On the use of polynomial models in multiobjective directional direct search by Brás, C. P., Custódio, A. L.

“…Polynomial interpolation or regression models are an important tool in Derivative-free Optimization, acting as surrogates of the real function. In this work,…”
Get full text

Development of ethical competences in mental health and psychiatry: simulation with nursing students by Lopes, R., Moreira, I., Neves, M., Brás, C., Rodrigues, R.

“…IntroductionSimulation as a pedagogical strategy contributes to improving the acquisition, consolidation and retention of knowledge and is very attractive for…”
Get full text

Distinct right ventricle remodeling in response to pressure overload in the rat by Mendes-Ferreira, P, Santos-Ribeiro, D, Adão, R, Maia-Rocha, C, Mendes-Ferreira, M, Sousa-Mendes, C, Leite-Moreira, A F, Brás-Silva, C

“…Pulmonary arterial hypertension (PAH), the most serious chronic disorder of the pulmonary circulation, is characterized by pulmonary vasoconstriction and…”
Get more information

Parallel strategies for Direct Multisearch by Tavares, S., Brás, C. P., Custódio, A. L., Duarte, V., Medeiros, P.

“…Direct multisearch (DMS) is a derivative-free optimization class of algorithms, suited for computing approximations to the complete Pareto front of a given…”
Get full text

Monitoring the interactions between alpha-synuclein and Tau in vitro and in vivo using bimolecular fluorescence complementation by Torres-Garcia, Laura, P. Domingues, Joana M., Brandi, Edoardo, Haikal, Caroline, Mudannayake, Janitha M., Brás, Inês C., Gerhardt, Ellen, Li, Wen, Svanbergsson, Alexander, Outeiro, Tiago F., Gouras, Gunnar K., Li, Jia-Yi

“…Parkinson’s disease (PD) and Alzheimer’s disease (AD) are characterized by pathological accumulation and aggregation of different amyloidogenic proteins,…”
Get full text

Large-scale unconstrained optimization using separable cubic modeling and matrix-free subspace minimization by Brás, C. P., Martínez, J. M., Raydan, M.

“…We present a new algorithm for solving large-scale unconstrained optimization problems that uses cubic models, matrix-free subspace minimization, and…”
Get full text

Cognitive Dysfunction Screening in Peritoneal Dialysis Patients: A Cross-Sectional Study by Brás, Ana C, Marques, Joana, Fernandes, Vasco, Ferreira, Ana C

“…Mild cognitive impairment (MCI) in peritoneal dialysis (PD) patients has been described as a risk factor for worse outcomes such as peritonitis, technique…”
Get full text

Ectosomes and exosomes modulate neuronal spontaneous activity by Brás, Inês C., Khani, Mohammad H., Riedel, Dietmar, Parfentev, Iwan, Gerhardt, Ellen, van Riesen, Christoph, Urlaub, Henning, Gollisch, Tim, Outeiro, Tiago F.

“…Extracellular vesicles (EVs) are important mediators in intercellular communication. However, understanding the biological origin and functional effects of EVs…”
Get full text

Biasing the native α-synuclein conformational ensemble towards compact states abolishes aggregation and neurotoxicity by Carija, Anita, Pinheiro, Francisca, Pujols, Jordi, Brás, Inês C, Lázaro, Diana Fernandes, Santambrogio, Carlo, Grandori, Rita, Outeiro, Tiago F, Navarro, Susanna, Ventura, Salvador

“…The aggregation of α-synuclein (α-syn) into amyloid fibrils is a major pathological hallmark of Parkinson's disease (PD) and other synucleinopathies. The…”
Get full text

Crosstalk Between Chaperone-Mediated Protein Disaggregation and Proteolytic Pathways in Aging and Disease by Feleciano, Diogo R, Juenemann, Katrin, Iburg, Manuel, Brás, Inês C, Holmberg, Carina I, Kirstein, Janine

“…A functional protein quality control machinery is crucial to maintain cellular and organismal physiology. Perturbation in the protein homeostasis network can…”
Get full text

Rodent models of heart failure: an updated review by Gomes, A. C., Falcão-Pires, I., Pires, A. L., Brás-Silva, C., Leite-Moreira, A. F.

“…Heart failure (HF) is one of the major health and economic burdens worldwide, and its prevalence is continuously increasing. The study of HF requires reliable…”
Get full text

A pain to the patient and to the doctor by Brás, Pedro C, Dias, Sara P

Get more information

Multiple system atrophy: Inspiratory sighs as a key polysomnographic sign to early diagnosis? by Caldeira, J.N., Moita, J., Brás, A.C.

Get full text

Molecular Mechanisms Mediating the Transfer of Disease-Associated Proteins and Effects on Neuronal Activity by Brás, Inês C, Khani, Mohammad H, Vasili, Eftychia, Möbius, Wiebke, Riedel, Dietmar, Parfentev, Iwan, Gerhardt, Ellen, Fahlbusch, Christiane, Urlaub, Henning, Zweckstetter, Markus, Gollisch, Tim, Outeiro, Tiago F

“…Various cellular pathways have been implicated in the transfer of disease-related proteins between cells, contributing to disease progression and…”
Get more information

Intraventricular pressure gradients in heart failure by Guerra, M, Brás-Silva, C, Amorim, M J, Moura, C, Bastos, P, Leite-Moreira, A F

“…The aim of the present study was to characterize intraventricular pressure gradients (IVPGs) in an animal model of chronic heart failure. New Zealand rabbits…”
Get full text

Long-term outcomes and quality of life assessment after posterior component separation with transversus abdominis muscle release (TAR) by Sadava, E. E., Peña, M. E., Bras Harriott, C., Casas, M. A., Schlottmann, F., Laxague, F.

“…Background Although transversus abdominis release (TAR) to treat large incisional hernias has shown favorable postoperative outcomes, devastating complications…”
Get full text

Modulation of myocardial stiffness by β-adrenergic stimulation--its role in normal and failing heart by Falcao-Pires, I, Fontes-Sousa, A P, Lopes-Conceiçao, L, Brás-Silva, C, Leite-Moreira, A F

“…The acute effects of beta-adrenergic stimulation on myocardial stiffness were evaluated. New-Zealand white rabbits were treated with saline (control group) or…”
Get full text

Influence of weather on seizure frequency — Clinical experience in the emergency room of a tertiary hospital by Brás, Pedro C., Barros, Ariana, Vaz, Soraia, Sequeira, João, Melancia, Diana, Fernandes, Andreia, de Sousa, Ary, Dias, Sara P., Menezes Cordeiro, Inês, Manita, Manuel

“…Some patients with epilepsy identify weather as a typical seizure trigger. However, it is yet to be confirmed. Thus, we aimed to evaluate possible…”
Get full text

Nitric oxide and prostaglandins - important players in endothelin-1 induced myocardial distensibility by Brás-Silva, C, Monteiro-Sousa, D, Duarte, A J, Guerra, M, Fontes-Sousa, A P, Moura, C, Areias, J C, Leite Moreira, A F

“…This study investigated whether endothelin (ET)-1-induced increase in myocardial distensibility is preserved in heart failure (HF) and whether it is modulated…”
Get full text