Search Results - "Bozso, Zsolt"

Impact of Two Neuronal Sigma-1 Receptor Modulators, PRE084 and DMT, on Neurogenesis and Neuroinflammation in an Aβ1–42-Injected, Wild-Type Mouse Model of AD by Borbély, Emőke, Varga, Viktória, Szögi, Titanilla, Schuster, Ildikó, Bozsó, Zsolt, Penke, Botond, Fülöp, Lívia

“…Alzheimer’s disease (AD) is the most common form of dementia characterized by cognitive dysfunctions. Pharmacological interventions to slow the progression of…”
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Liquid Chromatographic Enantioseparation of Newly Synthesized Fluorinated Tryptophan Analogs Applying Macrocyclic Glycopeptides-Based Chiral Stationary Phases Utilizing Core-Shell Particles by Tanács, Dániel, Berkecz, Róbert, Bozsó, Zsolt, Tóth, Gábor K, Armstrong, Daniel W, Péter, Antal, Ilisz, István

“…Due to the favorable features obtained through the incorporation of fluorine atom(s), fluorinated drugs are a group with emerging pharmaceutical importance. As…”
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Examination of Longitudinal Alterations in Alzheimer’s Disease-Related Neurogenesis in an APP/PS1 Transgenic Mouse Model, and the Effects of P33, a Putative Neuroprotective Agent Thereon by Szögi, Titanilla, Borbély, Emőke, Schuster, Ildikó, Bozsó, Zsolt, Sántha, Miklós, Tóth, Melinda E., Penke, Botond, Fülöp, Lívia

“…Neurogenesis plays a crucial role in cognitive processes. During aging and in Alzheimer’s disease (AD), altered neurogenesis and neuroinflammation are evident…”
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Effects of the Pentapeptide P33 on Memory and Synaptic Plasticity in APP/PS1 Transgenic Mice: A Novel Mechanism Presenting the Protein Fe65 as a Target by Szögi, Titanilla, Schuster, Ildikó, Borbély, Emőke, Gyebrovszki, Andrea, Bozsó, Zsolt, Gera, János, Rajkó, Róbert, Sántha, Miklós, Penke, Botond, Fülöp, Lívia

“…Regulated intramembrane proteolysis (RIP) of the amyloid precursor protein (APP) leads to the formation of fragments, among which the intracellular domain of…”
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Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein by Oláh, Judit, Vincze, Orsolya, Virók, Dezsõ, Simon, Dóra, Bozsó, Zsolt, Tõkési, Natália, Horváth, István, Hlavanda, Emma, Kovács, János, Magyar, Anna, Szũcs, Mária, Orosz, Ferenc, Penke, Botond, Ovádi, Judit

“…The disordered tubulin polymerization promoting protein (TPPP/p25) was found to be co-enriched in neuronal and glial inclusions with α-synuclein in Parkinson…”
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The Nuclear Localization Signal of NF-κB p50 Enters the Cells via Syndecan-Mediated Endocytosis and Inhibits NF-κB Activity by Letoha, Annamária, Hudák, Anett, Bozsó, Zsolt, Vizler, Csaba, Veres, Gábor, Szilák, László, Letoha, Tamás

“…It is well established that cationic peptides can enter cells following attachment to polyanionic membrane components. We report that the basic nuclear…”
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Kisspeptin-8 Induces Anxiety-Like Behavior and Hypolocomotion by Activating the HPA Axis and Increasing GABA Release in the Nucleus Accumbens in Rats by Ibos, Katalin Eszter, Bodnár, Éva, Bagosi, Zsolt, Bozsó, Zsolt, Tóth, Gábor, Szabó, Gyula, Csabafi, Krisztina

“…Kisspeptins (Kp) are RF-amide neuropeptide regulators of the reproductive axis that also influence anxiety, locomotion, and metabolism. We aimed to investigate…”
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Biotin and Glutathione Targeting of Solid Nanoparticles to Cross Human Brain Endothelial Cells by Veszelka, Szilvia, Meszaros, Maria, Kiss, Lorand, Kota, Zoltan, Pali, Tibor, Hoyk, Zsofia, Bozso, Zsolt, Fulop, Livia, Toth, Andras, Rakhely, Gabor, Deli, Maria A

“…The blood-brain barrier restricts drug penetration to the central nervous system. Targeted nanocarriers are new potential tools to increase the brain entry of…”
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Cell-penetrating peptide exploited syndecans by Letoha, Tamás, Keller-Pintér, Anikó, Kusz, Erzsébet, Kolozsi, Csongor, Bozsó, Zsolt, Tóth, Gábor, Vizler, Csaba, Oláh, Zoltán, Szilák, László

“…Cell-penetrating peptides (CPPs) are short peptides capable of translocating across the plasma membrane of live cells and transporting conjugated compounds…”
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Structural Optimization of Foldamer-Dendrimer Conjugates as Multivalent Agents against the Toxic Effects of Amyloid Beta Oligomers by Bartus, Éva, Olajos, Gábor, Schuster, Ildikó, Bozsó, Zsolt, Deli, Mária A, Veszelka, Szilvia, Walter, Fruzsina R, Datki, Zsolt, Szakonyi, Zsolt, Martinek, Tamás A, Fülöp, Livia

“…Alzheimer's disease is one of the most common chronic neurodegenerative disorders. Despite several in vivo and clinical studies, the cause of the disease is…”
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A foldamer-dendrimer conjugate neutralizes synaptotoxic β-amyloid oligomers by Fülöp, Lívia, Mándity, István M, Juhász, Gábor, Szegedi, Viktor, Hetényi, Anasztázia, Wéber, Edit, Bozsó, Zsolt, Simon, Dóra, Benkő, Mária, Király, Zoltán, Martinek, Tamás A

“…Unnatural self-organizing biomimetic polymers (foldamers) emerged as promising materials for biomolecule recognition and inhibition. Our goal was to construct…”
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Anxiolytic- and antidepressant-like actions of Urocortin 2 and its fragments in mice by Bagosi, Zsolt, Csabafi, Krisztina, Balangó, Beáta, Pintér, Dávid, Szolomájer-Csikós, Orsolya, Bozsó, Zsolt, Tóth, Gábor, Telegdy, Gyula, Szabó, Gyula

“…•C57BL/6 mice were injected icv with Ucn2, Ucn2 (1–21) or Ucn2 (22–38).•C57BL/6 mice were evaluated in elevated plus-maze test and forced swim test.•Ucn2 and…”
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Abeta(1-42) Enhances Neuronal Excitability in the CA1 via NR2B Subunit-Containing NMDA Receptors by Fülöp, Lívia, Penke, Botond, Bozsó, Zsolt, Juhász, Gábor, Varga, Edina, Szegedi, Viktor

“…Neuronal hyperexcitability is a phenomenon associated with early Alzheimer’s disease. The underlying mechanism is considered to involve excessive activation of…”
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GABA A receptor subunit deregulation in the hippocampus of human foetuses with Down syndrome by Milenkovic, Ivan, Stojanovic, Tamara, Aronica, Eleonora, Fülöp, Livia, Bozsó, Zsolt, Máté, Zoltán, Yanagawa, Yuchio, Adle-Biassette, Homa, Lubec, Gert, Szabó, Gábor, Harkany, Tibor, Kovács, Gábor G, Keimpema, Erik

“…The function, regulation and cellular distribution of GABA receptor subunits have been extensively documented in the adult rodent brain and are linked to…”
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Docosahexaenoic acid reduces amyloid-β induced toxicity in cells of the neurovascular unit by Veszelka, Szilvia, Tóth, Andrea E, Walter, Fruzsina R, Datki, Zsolt, Mózes, Emese, Fülöp, Lívia, Bozsó, Zsolt, Hellinger, Eva, Vastag, Monika, Orsolits, Barbara, Környei, Zsuzsanna, Penke, Botond, Deli, Mária A

“…Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β peptides (Aβ) as perivascular deposits and senile plaques in the brain. The intake…”
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Searching for improved mimetic peptides inhibitors preventing conformational transition of amyloid-β42 monomer by Gera, János, Szögi, Titanilla, Bozsó, Zsolt, Fülöp, Livia, Barrera, Exequiel E., Rodriguez, Ana M., Méndez, Luciana, Delpiccolo, Carina M.L., Mata, Ernesto G., Cioffi, Federica, Broersen, Kerensa, Paragi, Gabor, Enriz, Ricardo D.

“…[Display omitted] •A novel mimetic peptide that inhibits Aβ cytotoxicity at submicromolar concentration is reported.•Antiaggregant activities were measured…”
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Two pyridine derivatives as potential Cu(II) and Zn(II) chelators in therapy for Alzheimer's disease by Lakatos, Andrea, Zsigó, Eva, Hollender, Dominik, Nagy, Nóra V, Fülöp, Lívia, Simon, Dóra, Bozsó, Zsolt, Kiss, Tamás

“…Two pyridine derivatives, DMAP and ENDIP, have been investigated as possible metal chelators in the therapy of Alzheimer's disease. Their complex formation…”
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Proteomic study of the toxic effect of oligomeric A beta 1-42 in situ prepared from 'iso-A beta 1-42' by Foldi, Istvan, Datki, Zsolt L, Szabo, Zoltan, Bozso, Zsolt, Penke, Botond, Janaky, Tamas

“…Alzheimer's disease (AD) is the most prevalent form of neurodegenerative disorders even so the exact pathomechanism is still unclear. Recently, it is widely…”
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Acute intracerebral treatment with amyloid-beta (1-42) alters the profile of neuronal oscillations that accompany LTP induction and results in impaired LTP in freely behaving rats by Kalweit, Alexander Nikolai, Yang, Honghong, Colitti-Klausnitzer, Jens, Fülöp, Livia, Bozsó, Zsolt, Penke, Botond, Manahan-Vaughan, Denise

“…Accumulation of amyloid plaques comprises one of the major hallmarks of Alzheimer's disease (AD). In rodents, acute treatment with amyloid-beta (Aβ; 1-42)…”
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Exceptional in vivo catabolism of neurodegeneration-related aggregates by Datki, Zsolt, Olah, Zita, Hortobagyi, Tibor, Macsai, Lilla, Zsuga, Katalin, Fulop, Livia, Bozso, Zsolt, Galik, Bence, Acs, Eva, Foldi, Angela, Szarvas, Amanda, Kalman, Janos

“…Neurodegenerative diseases are linked to a systemic enzyme resistance of toxic aggregated molecules and their pathological consequences. This paper presents a…”
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