Widespread formation of toxic nitrated bisphenols indoors by heterogeneous reactions with HONO

With numerous structurally diverse indoor contaminants, indoor transformation chemistry has been largely unexplored. Here, by integrating protein affinity purification and nontargeted mass spectrometry analysis (PUCA), we identified a substantial class of previously unrecognized indoor transformatio...

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Bibliographic Details
Published in:	Science advances Vol. 8; no. 48; p. eabq7023
Main Authors:	Yang, Diwen, Liu, Qifan, Wang, Sizhi, Bozorg, Matin, Liu, Jiabao, Nair, Pranav, Balaguer, Patrick, Song, Datong, Krause, Henry, Ouazia, Boualem, Abbatt, Jonathan P D, Peng, Hui
Format:	Journal Article
Language:	English
Published:	United States American Association for the Advancement of Science 02-12-2022
Subjects:	Atmospheric Science Earth, Environmental, Ecological, and Space Sciences Environmental Studies SciAdv r-articles
Online Access:	Get full text
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Summary:	With numerous structurally diverse indoor contaminants, indoor transformation chemistry has been largely unexplored. Here, by integrating protein affinity purification and nontargeted mass spectrometry analysis (PUCA), we identified a substantial class of previously unrecognized indoor transformation products formed through gas-surface reactions with nitrous acid (HONO). Through the PUCA, we identified a noncommercial compound, nitrated bisphenol A (BPA), from house dust extracts strongly binding to estrogen-related receptor γ. The compound was detected in 28 of 31 house dust samples with comparable concentrations (ND to 0.30 μg/g) to BPA. Via exposing gaseous HONO to surface-bound BPA, we demonstrated it likely forms via a heterogeneous indoor chemical transformation that is highly selective toward bisphenols with electron-rich aromatic rings. We used N-nitrite for in situ labeling and found 110 nitration products formed from indoor contaminants with distinct aromatic moieties. This study demonstrates a previously unidentified class of chemical reactions involving indoor HONO, which should be incorporated into the risk evaluation of indoor contaminants, particularly bisphenols.
ISSN:	2375-2548 2375-2548
DOI:	10.1126/sciadv.abq7023