Search Results - "Bozkurt, Turgut Emrah"
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Endocannabinoid System in the Airways
Published in Molecules (Basel, Switzerland) (17-12-2019)“…Cannabinoids and the mammalian endocannabinoid system is an important research area of interest and attracted many researchers because of their widespread…”
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2
Biyobenzer ilaçların preklinik ve klinik performanslarının değerlendirilmesi
Published in Ege tıp dergisi (20-01-2021)“…Biyoteknolojik ilaçlar doku veya hücre kültürleri gibi canlı organizmalar aracılığıyla genellikle rekombinant DNA teknolojisi kullanılarak üretilen kompleks,…”
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3
Endocannabinoid metabolism inhibition ameliorates ovalbumin-induced allergic airway inflammation and hyperreactivity in Guinea pigs
Published in Life sciences (1973) (01-10-2022)“…Endocannabinoids are biologically active cannabinoid-related substances endogenously synthesized in many mammalian tissues. Mainly two enzymes carry out their…”
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4
The effect of mitochondria-targeted slow hydrogen sulfide releasing donor AP39-treatment on airway inflammation
Published in European journal of pharmacology (05-05-2023)“…Mitochondrial dysfunction has been shown to contribute to the pathophysiology of airway diseases. Therefore, mitochondria are targeted in the development of…”
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5
The effects of fatty acid amide hydrolase and monoacylglycerol lipase inhibitor treatments on lipopolysaccharide-induced airway inflammation in mice
Published in Pulmonary pharmacology & therapeutics (01-06-2020)“…Cannabinoids and the endocannabinoid system significantly contributes to the airway inflammation. Fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase…”
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6
The effect of cannabinoids on dinitrofluorobenzene-induced experimental asthma in mice
Published in Respiratory physiology & neurobiology (01-09-2016)“…Highlights • There is limited data about the effects of cannabinoids in airway inflammation. • CB1 receptor stimulation inhibits cholinergic acetylcholine…”
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7
Stimulation of cannabinoid CB1 receptors prevents nerve-mediated airway hyperreactivity in NGF-induced inflammation in mouse airways
Published in European journal of pharmacology (05-04-2016)“…Cannabinoids are known to inhibit neuronal activity and have significant immunomodulatory effects which suggest a role in inflammatory airway diseases. In the…”
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Effects of intranasal treatment with slow (GYY4137) and rapid (NaHS) donors of hydrogen sulfide in lipopolysaccharide-induced airway inflammation in mice
Published in Pulmonary pharmacology & therapeutics (01-08-2017)“…Abstract We have investigated the effects of slow (GYY4137) and rapid (NaHS) hydrogen sulfide (H2 S) releasing donors in lipopolysaccharide (LPS)-induced…”
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Investigation of the relationship between chronic montelukast treatment, asthma and depression‑like behavior in mice
Published in Experimental and therapeutic medicine (01-01-2021)“…In 2008, the Food and Drug Administration of the US issued a warning about the neuropsychiatric side effects of montelukast. Previous clinical studies on…”
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10
The effects of systemic and local fatty acid amide hydrolase and monoacylglycerol lipase inhibitor treatments on the metabolomic profile of lungs
Published in Biomedical chromatography (01-01-2022)“…The contribution of the endocannabinoid system to both physiology and pathological processes in the respiratory system makes it a promising target for…”
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11
Hydrogen sulfide donors prevent lipopolysaccharide‐induced airway hyperreactivity in an in vitro model of chronic inflammation in mice
Published in Basic & clinical pharmacology & toxicology (01-05-2021)“…We aimed to investigate and compare the effects of rapid (NaHS) and slow (GYY4137 and AP39) hydrogen sulfide (H2S) releasing donors on LPS‐induced tracheal…”
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12
Rho Kinase and Protein Kinase C Pathways are Responsible for Enhanced Carbachol Contraction in Permeabilized Detrusor in a Rat Model of Cystitis
Published in Basic & clinical pharmacology & toxicology (01-11-2018)“…Interstitial cystitis is a syndrome characterized by detrusor overactivity and chronic inflammation of the bladder. The mechanisms responsible for the altered…”
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13
M1 and M3 muscarinic receptors are involved in the release of urinary bladder-derived relaxant factor
Published in Pharmacological research (01-05-2009)Get full text
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14
The vasorelaxant effect of hydrogen sulfide is enhanced in streptozotocin-induced diabetic rats
Published in Naunyn-Schmiedeberg's archives of pharmacology (01-05-2011)“…Hydrogen sulfide (H 2 S) is an endogenous gas which has potent relaxant effect in vascular and nonvascular smooth muscles. In the present study, we have…”
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15
Rat urinary bladder-derived relaxant factor: Studies on its nature and release by coaxial bioassay system
Published in European journal of pharmacology (04-09-2008)“…The present study was designed to characterize the urinary bladder-derived relaxant factor that was demonstrated by acetylcholine-induced relaxation response…”
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M 1 and M 3 muscarinic receptors are involved in the release of urinary bladder-derived relaxant factor
Published in Pharmacological research (2009)“…We have investigated the muscarinic receptor subtype(s) mediating the release of urinary bladder-derived relaxant factor that is demonstrated by a coaxial…”
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The investigation into indomethacin-induced potentiation of the contractile response to antigen in ovalbumin-sensitized guinea-pig tracheas
Published in Fundamental & clinical pharmacology (01-06-2012)“…In the present study, we investigated the mediators involved in the potentiation of antigen‐induced contractions by indomethacin in tracheas isolated from…”
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18
M(1) and M(3) muscarinic receptors are involved in the release of urinary bladder-derived relaxant factor
Published in Pharmacological research (01-05-2009)“…We have investigated the muscarinic receptor subtype(s) mediating the release of urinary bladder-derived relaxant factor that is demonstrated by a coaxial…”
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19
Evaluation of the rat bladder-derived relaxant factor by coaxial bioassay system
Published in European journal of pharmacology (14-07-2004)“…The release of bladder-derived relaxant factor in a coaxial bioassay system and the effects of reactive oxygen species were studied. After precontraction with…”
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