The Presence of Some Humoral Immunologic Indicators and Clinical Manifestations in Cryoglobulin Positive Heroin Addicts without Evidence of Hepatitis Virus Infection

The Presence of Some Humoral Immunologic Indicators and Clinical Manifestations in Cryoglobulin Positive Heroin Addicts without Evidence of Hepatitis Virus Infection

Cryoglobulins are single or mixed immunoglobulins that are subject to reversible precipitation at low temperatures. The aims of this paper were: 1. Comparison of cryoglobulin positive (CP), cryoglobulin negative (CN) heroin addicts and the control group (CG) in terms of serum immunoglobulins IgG, Ig...

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Published in:Srpski arhiv za celokupno lekarstvo Vol. 143; no. 5-6; pp. 296 - 300
Main Authors: Simonovska, Natasha, Chibishev, Andon, Bozinovskal, Cvetanka, Grchevska, Ladislava, Dimitrovskil, Kocho, Neceva, Violeta
Format: Journal Article
Language:English
Published: Serbia Serbian Medical Society 01-05-2015
Subjects:
Adult
Autoantibodies - analysis
Autoantibodies - blood
Autoantibodies - immunology
Autoantibodies - urine
complement
cryoglobulin
Cryoglobulinemia - blood
Cryoglobulins - analysis
Female
Hepatitis Viruses - immunology
heroin addicts without hepatitis infection
Heroin Dependence - blood
Heroin Dependence - immunology
Heroin Dependence - urine
Humans
Immunity, Humoral
immunoglobulins
Immunologic Tests
Male
Middle Aged
rheumatoid factor
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Summary:Cryoglobulins are single or mixed immunoglobulins that are subject to reversible precipitation at low temperatures. The aims of this paper were: 1. Comparison of cryoglobulin positive (CP), cryoglobulin negative (CN) heroin addicts and the control group (CG) in terms of serum immunoglobulins IgG, IgA and IgM and complement components C3 and C4; 2. Comparison of CP and CN heroin addicts in terms of rheumatoid factor (RF) and circulating immune complexes (CIC); 3. Assessment of clinical manifestations in CP heroin addicts. This is a comparative study of cases (outpatients) treated at the University Clinic of Toxicology in Skopje over 3.5 years, from January 2009 to June 2012. In this study 140 heroin addicts without HbsAg were examined, seronegative for HCV and HIV infections.They were divided into 2 groups: 70 CP and 70 CN heroin addicts. A previously designed self-administered questionnaire was used as a data source on participants. All heroin addicts underwent the following analyses: urea and creatinine in serum; creatinine in urine; proteinuria; 24-hour proteinuria; IgM, IgG, IgA, C3, C4; RF; CIC; creatinine clearance; ECG; toxicological analyses for opioids in a urine sample; cryoglobulins. In addition to these 2 groups, IgG, IgA, IgM, C3 and C4 were also examined in 70 healthy subjects (CG). The study showed that there was no statistically significant difference between CP, CN heroin addicts and CG regarding the concentration of IgA, IgG, IgM, C3 and C4, and between CP and CN regarding the concentration of CIC. There was significant difference between CP and CN regarding the concentration of RF. The following conditions were significantly more frequently manifested in CP than in CN heroin addicts: arthralgia, Raynaud's phenomenon, respiratory difficulties, neurological disorders, manifested skin changes, hematuria, 24-hour proteinuria levels, and decreased renal clearance. There were no differences in concentrations of IgG, IgA, IgM, C3, C4 and CIC, while there was a difference in concentration of RF between CP and CN heroin addicts. Clinical manifestations (arthralgias, Raynaud's phenomenon, respiratory, neurologic, renal disorders and skin changes) were more common in CP heroin addicts.
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ISSN:0370-8179
2406-0895
DOI:10.2298/SARH1506296S