Search Results - "Bozeman, Erica N."

Tumor membrane-based vaccine immunotherapy in combination with anti-CTLA-4 antibody confers protection against immune checkpoint resistant murine triple-negative breast cancer by Pack, Christopher D., Bommireddy, Ramireddy, Munoz, Luis E., Patel, Jaina M., Bozeman, Erica N., Dey, Paulami, Radhakrishnan, Vijayaraghavan, Vartabedian, Vincent F., Venkat, Kalpana, Ramachandiran, Sampath, Reddy, Shaker J. C., Selvaraj, Periasamy

“…Triple-negative breast cancer (TNBC) afflicts women at a younger age than other breast cancers and is associated with a worse clinical outcome. This poor…”
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Immunotherapeutic strategies for cancer treatment: A novel protein transfer approach for cancer vaccine development by Shashidharamurthy, Rangaiah, Bozeman, Erica N., Patel, Jaina, Kaur, Ramneet, Meganathan, Jeyandra, Selvaraj, Periasamy

“…Cancer cells have developed numerous ways to escape immune surveillance and gain unlimited proliferative capacity. Currently, several chemotherapeutic agents…”
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Expression of membrane anchored cytokines and B7-1 alters tumor microenvironment and induces protective antitumor immunity in a murine breast cancer model by Bozeman, Erica N, Cimino-Mathews, Ashley, Machiah, Deepa K, Patel, Jaina M, Krishnamoorthy, Arun, Tien, Linda, Shashidharamurthy, Rangaiah, Selvaraj, Periasamy

“…Highlights • Surface expression of cytokines (GPI-cytokines) reduced 4TO7 tumorigenicity. • GPI-cytokines may reduce systemic toxicity associated with soluble…”
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Dual-targeting Wnt and uPA receptors using peptide conjugated ultra-small nanoparticle drug carriers inhibited cancer stem-cell phenotype in chemo-resistant breast cancer by Miller-Kleinhenz, Jasmine, Guo, Xiangxue, Qian, Weiping, Zhou, Hongyu, Bozeman, Erica N., Zhu, Lei, Ji, Xin, Wang, Y.Andrew, Styblo, Toncred, O'Regan, Ruth, Mao, Hui, Yang, Lily

“…Heterogeneous tumor cells, high incidence of tumor recurrence, and decrease in overall survival are the major challenges for the treatment of chemo-resistant…”
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Cancer vaccine development: designing tumor cells for greater immunogenicity by Bozeman, Erica N, Shashidharamurthy, Rangaiah, Paulos, Simon A, Palaniappan, Ravi, D'Souza, Martin, Selvaraj, Periasamy

“…Cancer vaccine development is one of the most hopeful and exhilarating areas in cancer research. For this reason, there has been a growing interest in the…”
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Tumor Penetrating Theranostic Nanoparticles for Enhancement of Targeted and Image-guided Drug Delivery into Peritoneal Tumors following Intraperitoneal Delivery by Gao, Ning, Bozeman, Erica N, Qian, Weiping, Wang, Liya, Chen, Hongyu, Lipowska, Malgorzata, Staley, Charles A, Wang, Y Andrew, Mao, Hui, Yang, Lily

“…The major obstacles in intraperitoneal (i.p.) chemotherapy of peritoneal tumors are fast absorption of drugs into the blood circulation, local and systemic…”
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Targeted nanoparticles for image-guided treatment of triple-negative breast cancer: clinical significance and technological advances by Miller-Kleinhenz, Jasmine M., Bozeman, Erica N., Yang, Lily

“…Effective treatment of triple‐negative breast cancer (TNBC) with its aggressive tumor biology, highly heterogeneous tumor cells, and poor prognosis requires an…”
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Allogeneic tumor cell vaccines: The promise and limitations in clinical trials by Srivatsan, Sanjay, Patel, Jaina M, Bozeman, Erica N, Imasuen, Imade E, He, Sara, Daniels, Danielle, Selvaraj, Periasamy

“…The high mortality rate associated with cancer and its resistance to conventional treatments such as radiation and chemotherapy has led to the investigation of…”
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Plasma membrane vesicles decorated with glycolipid-anchored antigens and adjuvants via protein transfer as an antigen delivery platform for inhibition of tumor growth by Patel, Jaina M, Vartabedian, Vincent F, Bozeman, Erica N, Caoyonan, Brianne E, Srivatsan, Sanjay, Pack, Christopher D, Dey, Paulami, D'Souza, Martin J, Yang, Lily, Selvaraj, Periasamy

“…Abstract Antigen delivered within particulate materials leads to enhanced antigen-specific immunity compared to soluble administration of antigen. However,…”
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Therapeutic efficacy of PD-L1 blockade in a breast cancer model is enhanced by cellular vaccines expressing B7-1 and glycolipid-anchored IL-12 by Bozeman, Erica N, He, Sara, Shafizadeh, Yalda, Selvaraj, Periasamy

“…Immunotherapeutic approaches have emerged as promising strategies to treat various cancers, including breast cancer. A single approach, however, is unlikely to…”
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Taming dendritic cells with TIM-3: another immunosuppressive strategy used by tumors by Patel, Jaina, Bozeman, Erica N, Selvaraj, Periasamy

“…Evaluation of: Chiba S, Baghdadi M, Akiba H et al. Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between…”
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Theranostic nanoparticles carrying doxorubicin attenuate targeting ligand specific antibody responses following systemic delivery by Yang, Emmy, Qian, Weiping, Cao, Zehong, Wang, Liya, Bozeman, Erica N, Ward, Christina, Yang, Bin, Selvaraj, Periasamy, Lipowska, Malgorzata, Wang, Y Andrew, Mao, Hui, Yang, Lily

“…Understanding the effects of immune responses on targeted delivery of nanoparticles is important for clinical translations of new cancer imaging and…”
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Abstract 3537: Manipulation of local and systemic immune suppression by GPI-anchored immune stimulatory proteins by Bozeman, Erica N., Shashidharamurthy, Rangaiah, Selvaraj, Periasamy

“…Abstract Each day in the United States alone, approximately 3400 people are diagnosed while another 1500 people die from cancer. Breast cancer is the most…”
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HER-2+ breast cancer cells expressing GPI-anchored cytokines induce long lasting antitumor memory response by Munoz, Luis E, Bommireddy, Ramireddy, Margaroli, Camilla, Shafizadeh, Yalda, Bozeman, Erica N, Menon, Ashwathi P, Kumar, Jayanth, Lakshmanan, Ramana, Selvaraj, Periasamy

“…Abstract Breast cancer is the leading cause of death among female cancer patients. Human epidermal growth factor receptor 2 (HER-2) overexpression is…”
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Abstract 3635: Enhanced intra-tumoral immune cell infiltration following tumor targeted delivery of chemotherapy using theranostic nanoparticles in an orthotopic mouse pancreatic model by Bozeman, Erica N., Gao, Ning, Qian, Weiping, Wang, Andrew, Yang, Lily

“…Abstract Development of novel therapeutics that have the dual capacity to de-bulk a tumor mass as well as induce tumor-specific immunological responses are…”
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Membrane-based immunotherapy with immune checkpoint blockade antibodies confers protection against metastatic breast cancer by Bommireddy, Ramireddy, Pack, Christopher D, Bozeman, Erica N, Patel, Jaina M, Vartebedian, Vincent F, Munoz, Luis E, Shafizadeh, Yalda, Menon, Ashwathi P, Lakshmanan, Ramana, Reddy, Shaker JC, Selvaraj, Periasamy

“…Abstract Objective The 4T1 triple negative breast cancer (TNBC) model resembles many of the hallmarks of advanced TNBC in humans. In this study we investigate…”
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Hydrodynamic delivery of plasmid DNA encoding human FcγR-Ig dimers blocks immune-complex mediated inflammation in mice by Shashidharamurthy, R, Machiah, D, Bozeman, E N, Srivatsan, S, Patel, J, Cho, A, Jacob, J, Selvaraj, P

“…Therapeutic use and function of recombinant molecules can be studied by the expression of foreign genes in mice. In this study, we have expressed human Fcγ…”
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Membrane anchored immune stimulatory proteins enhance anti-tumor immunity in breast cancer models by Bozeman, Erica N

“…Despite significant advances being made in the cancer field, breast cancer accounts for millions of deaths worldwide. Multiple strategies have been employed to…”
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