Search Results - "Boze, Melanie A."

Orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors by Koltun, Dmitry O., Vasilevich, Natalya I., Parkhill, Eric Q., Glushkov, Andrei I., Zilbershtein, Timur M., Mayboroda, Elena I., Boze, Melanie A., Cole, Andrew G., Henderson, Ian, Zautke, Nathan A., Brunn, Sandra A., Chu, Nancy, Hao, Jia, Mollova, Nevena, Leung, Kwan, Chisholm, Jeffrey W., Zablocki, Jeff

“…We discovered a structurally novel SCD inhibitor CVT-11,563 (IC50 119nM, HEPG2 assay), selective against Δ5 and Δ6 desaturases, with excellent PK parameters…”
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Orally bioavailable, liver-selective stearoyl-CoA desaturase (SCD) inhibitors by KOLTUN, Dmitry O, VASILEVICH, Natalya I, BRUNN, Sandra A, CHU, Nancy, JIA HAO, MOLLOVA, Nevena, LEUNG, Kwan, CHISHOLM, Jeffrey W, ZABLOCKI, Jeff, PARKHILL, Eric Q, GLUSHKOV, Andrei I, ZILBERSHTEIN, Timur M, MAYBORODA, Elena I, BOZE, Melanie A, COLE, Andrew G, HENDERSON, Ian, ZAUTKE, Nathan A

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