Search Results - "Bozarth, J M"

Antiplatelet and antithrombotic efficacy of DMP 728, a novel platelet GPIIb/IIIa receptor antagonist by MOUSA, S. A, BOZARTH, J. M, DE GRADO, W. F, THOOLEN, M. J, REILLY, T. M, FORSYTHE, M. S, JACKSON, S. M, LEAMY, A, DIEMER, M. M, KAPIL, R. P, KNABB, R. M, MAYO, M. C, PIERCE, S. K

“…Currently used antiplatelet drugs, including aspirin, ticlopidine, and others, are effective against certain but not all of the many endogenous platelet…”
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Relationship between phosphatidylinositol turnover and Ca++ mobilization induced by alpha-1 adrenoceptor stimulation in the rat aorta by Chiu, A T, Bozarth, J M, Timmermans, P B

“…In this study the causal relationship between alpha-1 adrenoceptor activation mediating contraction in rat aorta and the mediatory responses, such as…”
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Ca++ utilization in the constriction of rat aorta to stimulation of protein kinase C by phorbol dibutyrate by Chiu, A T, Bozarth, J M, Forsythe, M S, Timmermans, P B

“…To determine the role of activated protein kinase C in vascular smooth muscle contraction, phorbol dibutyrate was used to stimulate this enzyme in order to…”
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Oral Antiplatelet Efficacy and Specificity of a Novel Nonpeptide Platelet GPIIb/IIIa Receptor Antagonist, DMP 802 by Mousa, Shaker A, Olson, Richard E, Bozarth, Jeffrey M, Lorelli, William, Forsythe, Mark S, Racanelli, Adrienne, Gibbs, Sandy, Schlingman, Karen, Bozarth, Tracy, Kapil, Ram, Wityak, John, Sielecki, Thais M, Wexler, Ruth R, Thoolen, Martin J, Slee, Andrew, Reilly, Thomas M, Anderson, Paul S, Friedman, Paul A

“…This study was undertaken to define the platelet glycoprotein αIIbβ3 integrin (GPII/IIIa) affinity, specificity, and oral antiplatelet efficacy of DMP 802, a…”
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Antiplatelet efficacy and specificity of DMP728, a novel platelet GPIIb/IIIa receptor antagonist by Mousa, S A, Bozarth, J M, Forsythe, M S, Lorelli, W, Thoolen, M J, Ramachandran, N, Jackson, S, De Grado, W, Reilly, T M

“…The present study was undertaken to define the platelet GPIIb/IIIa affinity and specificity of DMP728, the cyclic…”
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Effect of single oral dose of aspirin on human platelet functions and plasma plasminogen activator inhibitor-1 by Mousa, S A, Forsythe, M S, Bozarth, J M, Reilly, T M

“…Previous reports documented the inhibitory efficacy of different doses of aspirin on arachidonic acid (AA)-induced platelet aggregation, however, the…”
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Effect of thrombin inhibitors on platelet functions: comparative analysis of DuP 714 and hirudin by Reilly, T M, Knabb, R M, Hassell, S M, Bozarth, J M, Forsythe, M S, Mayo, M C, Racanelli, A L, Mousa, S A

“…Since thrombin plays an important role in platelet-mediated arterial thrombosis, we have examined the antiplatelet activity of a synthetic thrombin inhibitor,…”
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Thrombolytic and antithrombotic efficacy of the platelet GPIIb-IIIa antagonist DMP728 by Mousa, S A, Forsythe, M S, Diemer, M, Bozarth, J M, Reilly, T M

“…This study was undertaken to determine the antithrombotic and thrombolytic efficacy of DMP728 alone and in conjunction with thrombolytic agents. Coronary…”
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Platelet GPIIb/IIIa binding characteristics of small molecule RGD mimetic: distinct binding profile for Roxifiban by Mousa, Shaker A, Bozarth, Jeffrey M, Naik, Ulhas P, Slee, Andrew

“…A number of non‐peptide orally active RGD mimetic prodrug such as Orbofiban, Sibrafiban, SR121566, Roxifiban and others entered into the clinical evaluation…”
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Differential antiplatelet efficacy for various GPIIb/IIIa antagonists: Role of plasma calcium levels by MOUSA, Shaker A, BOZARTH, Jeffrey M, FORSYTHE, Mark S, SLEE, Andrew

“…The present study was undertaken to determine the effects of free ionized calcium influenced by either the anticoagulant used (citrate vs. heparin) or directly…”
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Platelet GPIIb/IIIa receptor occupancy studies using a novel fluoresceinated cyclic Arg-Gly-Asp peptide by Tsao, Peter W., Bozarth, Jeffrey M., Jackson, Sharon A., Forsythe, Mark S., Flint, Sandra K., Mousa, Shaker A.

“…DMP 728 is a potent and specific platelet GPIIb/IIIa antagonist. Like all GPIIb/IIIa antagonists, DMP 728 has a steep dose-response relationship in inhibiting…”
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Rapid and quantitative in vitro measurement of cellular chemotaxis and invasion by PENNO, M. B, HART, J. C, MOUSA, S. A, BOZARTH, J. M

“…An in vitro, fluorimetric method for cellular chemotaxis and invasion has been developed using a commercially available, disposable, 96-well chamber. This 4-18…”
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A Monoclonal Antibody That Recognizes the GPIIb/IIIa Antagonist DMP 728: Reversal of the Effects of DMP 728 on Platelet Aggregation and Bleeding Time in the Dog by Reilly, Thomas M, Mousa, Shaker A, Racanelli, Adrienne L, Thoolen, Martin J, Flint, Sandra K, Bozarth, Jeffrey M, Mu, Dun X, Walton, Harry L

“…Since hemorrhagic events represent a major safety concern associated with the use of new antithrombotic therapies such as glycoprotein (GP) IIb/IIIa receptor…”
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Inhibition of the thrombin-platelet reactions by DuP 714 by Chiu, A T, Mousa, S A, Pease, L J, Roscoe, W A, Bozarth, J M, Reilly, T M, Smith, R D, Timmermans, P B

“…The efficacy and specificity of a novel synthetic thrombin inhibitor, DuP 714, on thrombin-induced elevation of cytoplasmic calcium, fibrinogen binding and…”
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Novel technetium-99m-labeled platelet GPIIb/IIIa receptor antagonists as potential imaging agents for venous and arterial thrombosis by Mousa, S A, Bozarth, J M, Edwards, S, Carroll, T, Barrett, J

“…Either venous or arterial thrombosis is a potentially life-threatening event and existing diagnostic modalities are inadequate to diagnose and to determine the…”
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Ketene aminal-based lactam derivatives as a novel class of orally active FXa inhibitors by Shi, Yan, Zhang, Jing, Stein, Philip D., Shi, Mengxiao, O’Connor, Stephen P., Bisaha, Sharon N., Li, Chi, Atwal, Karnail S., Bisacchi, Gregory S., Sitkoff, Doree, Pudzianowski, Andrew T., Liu, Eddie C., Hartl, Karen S., Seiler, Steven M., Youssef, Sonia, Steinbacher, Thomas E., Schumacher, William A., Rendina, Alan R., Bozarth, Jeffrey M., Peterson, Tara L., Zhang, Ge, Zahler, Robert

“…N, N′-Disubstituted ketene aminals are good bioisosteres of thiourea functional groups. We report the design and synthesis of a novel class of ketene…”
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Antiplatelet efficacy of XV459, a novel nonpeptide platelet GPIIb/IIIa antagonist: comparative platelet binding profiles with c7E3 by Mousa, S A, Bozarth, J M, Lorelli, W, Forsythe, M S, Thoolen, M J, Slee, A M, Reilly, T M, Friedman, P A

“…Recent advances in the development of i.v. platelet glycoprotein alphaIIb/beta3 integrin (GPIIb/IIIa) antagonists led to the development of either a class of…”
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Using thrombelastography to determine the efficacy of the platelet glycoprotein IIb/IIIa antagonist, roxifiban, on platelet/fibrin-mediated clot dynamics in humans by Mousa, Shaker A, Bozarth, Jeffrey M, Seiffert, Dietmar, Feuerstein, Giora Z

“…The effect of platelet glycoprotein IIb/IIIa antagonists on the dynamics of platelet/fibrin clot formation and strength was determined using thrombelastography…”
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An improved method for the quantitation of cellular migration: Role of alpha v beta 3 integrin in endothelial and smooth muscle cell migration by Bozarth, J M, Penno, M B, Mousa, SA

“…The present study was undertaken to develop a simple and improved method for the accurate quantitation of cellular migration and to examine the role of alpha v…”
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Disposition and exposure of the fibrinogen receptor antagonist XV459 on alphaIIBbeta3 binding sites in the guinea pig by Barrett, J S, Yu, J, Kapil, R, Padovani, P, Brown, F, Ebling, W F, Corjay, M H, Reilly, T M, Bozarth, J M, Mousa, S A, Pieniaszek, Jr, H J

“…The disposition of XV459, a potent, selective GP IIb/IIIa antagonist, has been examined following intravenous administration of XP280, the benzenesulphonate…”
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