Search Results - "Boyton, R"

T cell immunity to Zika virus targets immunodominant epitopes that show cross-reactivity with other Flaviviruses by Reynolds, C. J., Suleyman, O. M., Ortega-Prieto, A. M., Skelton, J. K., Bonnesoeur, P., Blohm, A., Carregaro, V., Silva, J. S., James, E. A., Maillère, B., Dorner, M., Boyton, R. J., Altmann, D. M.

“…Zika virus (ZIKV) Infection has several outcomes from asymptomatic exposure to rash, conjunctivitis, Guillain-Barré syndrome or congenital Zika syndrome…”
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Natural killer cells, killer immunoglobulin‐like receptors and human leucocyte antigen class I in disease by Boyton, R. J., Altmann, D. M.

“…Summary Natural killer cells constitute a potent, rapid part of the innate immune response to infection or transformation, and also generate a link to priming…”
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Immune mechanisms and the impact of the disrupted lung microbiome in chronic bacterial lung infection and bronchiectasis by Boyton, R. J., Reynolds, C. J., Quigley, K. J., Altmann, D. M.

“…Summary Recent studies analysing immunogenetics and immune mechanisms controlling susceptibility to chronic bacterial infection in bronchiectasis implicate…”
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role of natural killer T cells in lung inflammation by Boyton, R

“…Invariant NK T cells (iNKT) bridge the innate and adaptive immune response, being characterized by the ability to use invariant T cell receptors to recognize…”
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Effects of temporarily suspending low-dose methotrexate treatment for 2 weeks after SARS-CoV-2 vaccine booster on vaccine response in immunosuppressed adults with inflammatory conditions: protocol for a multicentre randomised controlled trial and nested mechanistic substudy (Vaccine Response On/Off Methotrexate (VROOM) study) by Abhishek, Abhishek, Boyton, RJ, McKnight, Áine, Coates, Laura, Bluett, James, Barber, Vicki S, Cureton, Lucy, Francis, Anne, Appelbe, Duncan, Eldridge, Lucy, Julier, Patrick, Peckham, Nicholas, Valdes, Ana M, Rombach, Ines, Altmann, Daniel M, Nguyen-Van-Tam, Jonathan, Williams, Hywel C, Cook, Jonathan Alistair

“…IntroductionIt is unknown if a temporary break in long-term immune-suppressive treatment after vaccination against COVID-19 improves vaccine response. The…”
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Regulation of immunity in bronchiectasis by Boyton, R. J.

“…Bronchiectasis is a chronic, progressive lung disease where there is irreversible, abnormal dilatation of one or more bronchi, with chronic airway…”
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Diverse approaches to analysing the history of human and pathogen evolution: how to tell the story of the past 70 000 years by Altmann, D. M., Balloux, F., Boyton, R. J.

“…The meeting ‘Human evolution, migration and history revealed by genetics, immunity and infection’, along with the follow-on satellite meeting at the Kavli…”
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Human leucocyte antigen class II association in idiopathic bronchiectasis, a disease of chronic lung infection, implicates a role for adaptive immunity by Boyton, R.J, Smith, J, Jones, M, Reynolds, C, Ozerovitch, L, Chaudhry, A, Wilson, R, Rose, M, Altmann, D.M

“…The aetiology of idiopathic bronchiectasis, a lung disease where chronic inflammation and bacterial infection leads to progressive lung damage, is unknown. A…”
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Is selection for TCR affinity a factor in cytokine polarization? by Boyton, Rosemary J, Altmann, Daniel M

“…Many factors influence polarization of CD4 T cells to Th1 or Th2, including those collectively termed ‘strength of stimulation’, such as peptide dose and…”
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Toll-like receptors 2 and 4 and innate immunity in neutrophilic asthma and idiopathic bronchiectasis by Reynolds, C, Ozerovitch, L, Wilsen, R, Altmann, D, Boyton, R

“…[...]faced with clinical phenotypes of this level of complexity, it is perhaps not surprising that, as has been the case in analysis of sepsis and other…”
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Effect of tolerance induction to immunodominant T-cell epitopes of Sendai virus on gene expression following repeat administration to lung by GRIESENBACH, U, BOYTON, R. J, ALTON, E. W. F. W, SOMERTON, L, GARCIA, S. E, FERRARI, S, OWAKI, T, YA-FEN, Z, GEDDES, D. M, HASEGAWA, M, ALTMANN, D. M

“…Sendai virus (SeV) is able to transfect airway epithelial cells efficiently in vivo. However, as with other viral vectors, repeated administration leads to…”
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Asthma: new developments in cytokine regulation by BOYTON, R. J., ALTMANN, D. M.

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Transgenic models of autoimmune disease by Boyton, R. J., Altmann, D. M.

“…SUMMARY Transgenic and knockout mouse models have been invaluable for the elucidation of basic mechanisms in autoimmunity and have contributed new experimental…”
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The pulmonary physician in critical care • Illustrative case 5: HIV associated pneumonia by Boyton, R J, Mitchell, D M, Kon, O M

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Pneumocystis pneumonia in humans is caused by P jiroveci not P carinii by Miller, R

“…In patients with mild and moderately severe PCP the efficacy of clindamycin-primaquine was shown in a multicentre randomised prospective trial to be similar to…”
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The role of natural killer T cells in lung inflammation: Molecular and cellular themes in inflammation and immunology by BOYTON, R

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Glutamic acid decarboxylase T lymphocyte responses associated with susceptibility or resistance to type I diabetes: analysis in disease discordant human twins, non-obese diabetic mice and HLA-DQ transgenic mice by Boyton, R J, Lohmann, T, Londei, M, Kalbacher, H, Halder, T, Frater, A J, Douek, D C, Leslie, D G, Flavell, R A, Altmann, D M

“…Glutamic acid decarboxylase (GAD65) has been implicated as a targeted self antigen in the immune destruction of pancreatic beta cells. T cell responses to…”
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OP24 Neutralising antibody potency against SARS-CoV-2 wild-type and Omicron BA.1 and BA.4/5 variants in infliximab and vedolizumab treated patients with Inflammatory Bowel Disease after three doses of COVID-19 vaccine: a prospective multicentre cohort study by Liu, Z, Le, K, Zhou, X, Alexander, J, Lin, S, Bewshea, C, Chanchlani, N, Nice, R, McDonald, T, Lamb, C, Sebastian, S, Kok, K, Lees, C, Hart, A, Pollok, R, Boyton, R, Altmann, D, Pollock, K, Goodhand, J, Kennedy, N, Ahmad, T, Powell, N

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Time series analysis and mechanistic modelling of heterogeneity and sero-reversion in antibody responses to mild SARS‑CoV-2 infection by Manisty, Charlotte, Treibel, Thomas Alexander, Jensen, Melanie, Semper, Amanda, Joy, George, Gupta, Rishi K, Cutino-Moguel, Teresa, Andiapen, Mervyn, Jones, Jessica, Taylor, Stephen, Otter, Ashley, Pade, Corrina, Gibbons, Joseph, Lee, Jason, Bacon, Joanna, Thomas, Steve, Moon, Chris, Jones, Meleri, Williams, Dylan, Lambourne, Jonathan, Fontana, Marianna, Altmann, Daniel M, Boyton, Rosemary, Maini, Mala, McKnight, Aine, Chain, Benjamin, Noursadeghi, Mahdad, Moon, James C

“…SARS-CoV-2 serology is used to identify prior infection at individual and at population level. Extended longitudinal studies with multi-timepoint sampling to…”
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T cell immunity to Zika virus targets immunodominant epitopes that show cross-reactivity with other Flaviviruses by Reynolds, C., Suleyman, O., Ortega-Prieto, A., Skelton, J., Bonnesoeur, P., Blohm, A., Carregaro, V., Silva, J., James, E., Maillère, B., Dorner, M., Boyton, R., Altmann, D.

“…Abstract Zika virus (ZIKV) Infection has several outcomes from asymptomatic exposure to rash, conjunctivitis, Guillain-Barré syndrome or congenital Zika…”
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