Search Results - "Boyle, Gary W."

First-in-human study of alpibectir (BVL-GSK098), a novel potent anti-TB drug by Pieren, Michel, Abáigar Gutiérrez-Solana, Ana, Antonijoan Arbós, Rosa María, Boyle, Gary W, Davila, Myriam, Davy, Maria, Gitzinger, Marc, Husband, Lisa, Martínez-Martínez, María S, Mazarro, Dolores Ochoa, Pefani, Eleni, Penman, Sophie L, Remuiñán, Modesto J, Vlasakakis, Georgios, Zeitlinger, Markus, Dale, Glenn E

“…The clinical candidate alpibectir augments the activity of, and overcomes resistance to, the anti-TB drug ethionamide in vitro and in vivo. A Phase 1,…”
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GSK2556286 Is a Novel Antitubercular Drug Candidate Effective In Vivo with the Potential To Shorten Tuberculosis Treatment by Nuermberger, Eric L, Martínez-Martínez, Maria Santos, Sanz, Olalla, Urones, Beatriz, Esquivias, Jorge, Soni, Heena, Tasneen, Rokeya, Tyagi, Sandeep, Li, Si-Yang, Converse, Paul J, Boshoff, Helena I, Robertson, Gregory T, Besra, Gurdyal S, Abrahams, Katherine A, Upton, Anna M, Mdluli, Khisimuzi, Boyle, Gary W, Turner, Sam, Fotouhi, Nader, Cammack, Nicholas C, Siles, Juan Miguel, Alonso, Marta, Escribano, Jaime, Lelievre, Joel, Rullas-Trincado, Joaquin, Pérez-Herrán, Esther, Bates, Robert H, Maher-Edwards, Gareth, Barros, David, Ballell, Lluís, Jiménez, Elena

“…As a result of a high-throughput compound screening campaign using Mycobacterium tuberculosis-infected macrophages, a new drug candidate for the treatment of…”
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Disposition and metabolism of darapladib, a lipoprotein-associated phospholipase A2 inhibitor, in humans by Dave, Mehul, Nash, Mike, Young, Graeme C, Ellens, Harma, Magee, Mindy H, Roberts, Andrew D, Taylor, Maxine A, Greenhill, Robert W, Boyle, Gary W

“…The absorption, metabolism, and excretion of darapladib, a novel inhibitor of lipoprotein-associated phospholipase A2, was investigated in healthy male…”
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Alpibectir: Early Qualitative and Quantitative Metabolic Profiling from a First-Time-in-Human Study by Combining 19 F-NMR (Nuclear Magnetic Resonance), 1 H-NMR, and High-Resolution Mass Spectrometric Analyses by Weston, Daniel J., Thomas, Steve, Boyle, Gary W., Pieren, Michel

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Alpibectir: Early Qualitative and Quantitative Metabolic Profiling from a First-Time-in-Human Study by Combining 19F-NMR (Nuclear Magnetic Resonance), 1H-NMR, and High-Resolution Mass Spectrometric Analyses by Weston, Daniel J, Thomas, Steve, Boyle, Gary W, Pieren, Michel

“…Alpibectir (also known as BVL-GSK098 and GSK3729098) is a new chemical entity (NCE) with a novel mechanism for the treatment of tuberculosis. The disposition…”
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Alpibectir: Early Qualitative and Quantitative Metabolic Profiling from a First Time in Human Study by Combining 19 F-NMR, 1 H-NMR and HRMS Analyses by Weston, Daniel J, Thomas, Steve, Boyle, Gary W, Pieren, Michel

“…Alpibectir (also known as BVL-GSK098 and GSK3729098) is a new chemical entity with a novel mechanism for the treatment of tuberculosis. The disposition of…”
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