Search Results - "Boyle, F. Tom"

Dissecting the Determinants of Cyclin-Dependent Kinase 2 and Cyclin-Dependent Kinase 4 Inhibitor Selectivity by Pratt, David J, Bentley, Jo, Jewsbury, Philip, Boyle, F. Tom, Endicott, Jane A, Noble, Martin E. M

“…Cyclin dependent kinases are a key family of kinases involved in cell cycle regulation and are an attractive target for cancer chemotherapy. The roles of four…”
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Novel 4-anilinoquinazolines with C-6 carbon-linked side chains: Synthesis and structure–activity relationship of a series of potent, orally active, EGF receptor tyrosine kinase inhibitors by Hennequin, Laurent F.A., Ballard, Peter, Boyle, F. Tom, Delouvrié, Bénédicte, Ellston, Rebecca P.A., Halsall, Chris T., Harris, Craig S., Hudson, Kevin, Kendrew, Jane, Pease, J. Elizabeth, Ross, Helen S., Smith, Peter, Vincent, Jennifer L.

“…The discovery and SAR of a novel subseries of 4-anilinoquinazoline EGFR inhibitors substituted at the C-6 position with carbon-linked side chains are…”
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Paradoxical activation of Raf by a novel Raf inhibitor by Hall-Jackson, Clare A, Eyers, Patrick A, Cohen, Philip, Goedert, Michel, Tom Boyle, F, Hewitt, Neil, Plant, Helen, Hedge, Philip

“…Raf is a proto-oncogene that is activated in response to growth factors or phorbol esters, and is thought to activate MAP kinase kinase-1 (MKK1) and hence the…”
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Antifungal Antibiotics from Calcarisporium thermophilum: A New Source of 15-Azahomosterol Derivatives by Chrisp, Paul, Dewick, Paul M., Boyle, F. Tom

“…Two antifungal metabolites isolated from Calcarisporium thermophilum were identified as 15-azahom osterols related to the compounds previously isolated from…”
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