Search Results - "Boyle, Eileen"

From little subclones grow mighty oaks by Boyle, Eileen M., Davies, Faith E.

“…New genetic analyses demonstrate that the presence of low-frequency subclonal populations, including high-risk subclones, at diagnosis in multiple myeloma can…”
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BRAF and DIS3 Mutations Associate with Adverse Outcome in a Long-term Follow-up of Patients with Multiple Myeloma by Boyle, Eileen M, Ashby, Cody, Tytarenko, Ruslana G, Deshpande, Shayu, Wang, Hongwei, Wang, Yan, Rosenthal, Adam, Sawyer, Jeffrey, Tian, Erming, Flynt, Erin, Hoering, Antje, Johnson, Sarah K, Rutherford, Michael W, Wardell, Christopher P, Bauer, Michael A, Dumontet, Charles, Facon, Thierry, Thanendrarajan, Sharmilan, Schinke, Carolina D, Zangari, Maurizio, van Rhee, Frits, Barlogie, Bart, Cairns, David, Jackson, Graham, Thakurta, Anjan, Davies, Faith E, Morgan, Gareth J, Walker, Brian A

“…Copy-number changes and translocations have been studied extensively in many datasets with long-term follow-up. The impact of mutations remains debated given…”
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The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma by Boyle, Eileen M., Deshpande, Shayu, Tytarenko, Ruslana, Ashby, Cody, Wang, Yan, Bauer, Michael A., Johnson, Sarah K., Wardell, Christopher P., Thanendrarajan, Sharmilan, Zangari, Maurizio, Facon, Thierry, Dumontet, Charles, Barlogie, Bart, Arbini, Arnaldo, Rustad, Even H., Maura, Francesco, Landgren, Ola, Zhan, Fenghuang, van Rhee, Frits, Schinke, Carolina, Davies, Faith E., Morgan, Gareth J., Walker, Brian A.

“…Smoldering myeloma (SMM) is associated with a high-risk of progression to myeloma (MM). We report the results of a study of 82 patients with both targeted…”
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Mutational Spectrum, Copy Number Changes, and Outcome: Results of a Sequencing Study of Patients With Newly Diagnosed Myeloma by Walker, Brian A, Boyle, Eileen M, Wardell, Christopher P, Murison, Alex, Begum, Dil B, Dahir, Nasrin M, Proszek, Paula Z, Johnson, David C, Kaiser, Martin F, Melchor, Lorenzo, Aronson, Lauren I, Scales, Matthew, Pawlyn, Charlotte, Mirabella, Fabio, Jones, John R, Brioli, Annamaria, Mikulasova, Aneta, Cairns, David A, Gregory, Walter M, Quartilho, Ana, Drayson, Mark T, Russell, Nigel, Cook, Gordon, Jackson, Graham H, Leleu, Xavier, Davies, Faith E, Morgan, Gareth J

“…At the molecular level, myeloma is characterized by copy number abnormalities and recurrent translocations into the immunoglobulin heavy chain locus. Novel…”
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Efficacy and tolerability of nivolumab after allogeneic transplantation for relapsed Hodgkin lymphoma by Herbaux, Charles, Gauthier, Jordan, Brice, Pauline, Drumez, Elodie, Ysebaert, Loic, Doyen, Hélène, Fornecker, Luc, Bouabdallah, Krimo, Manson, Guillaume, Ghesquières, Hervé, Tabrizi, Reza, Hermet, Eric, Lazarovici, Julien, Thiebaut-Bertrand, Anne, Chauchet, Adrien, Demarquette, Hélène, Boyle, Eileen, Houot, Roch, Yakoub-Agha, Ibrahim, Morschhauser, Franck

“…Allogeneic hematopoietic cell transplantation (allo-HCT) is indicated for patients with relapsed or refractory Hodgkin lymphoma (HL). Although long-term…”
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Impact of Rare Structural Variant Events in Newly Diagnosed Multiple Myeloma by Chojnacka, Monika, Diamond, Benjamin, Ziccheddu, Bachisio, Rustad, Even, Maclachlan, Kylee, Papadimitriou, Marios, Boyle, Eileen M, Blaney, Patrick, Usmani, Saad, Morgan, Gareth, Landgren, Ola, Maura, Francesco

“…Whole-genome sequencing (WGS) of patients with newly diagnosed multiple myeloma (NDMM) has shown recurrent structural variant (SV) involvement in distinct…”
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Multiparameter flow cytometry in plasma cell disorders: when in doubt, go with the flow by Van de Wyngaert, Zoé, Boyle, Eileen M.

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APOBEC family mutational signatures are associated with poor prognosis translocations in multiple myeloma by Walker, Brian A., Wardell, Christopher P., Murison, Alex, Boyle, Eileen M., Begum, Dil B., Dahir, Nasrin M., Proszek, Paula Z., Melchor, Lorenzo, Pawlyn, Charlotte, Kaiser, Martin F., Johnson, David C., Qiang, Ya-Wei, Jones, John R., Cairns, David A., Gregory, Walter M., Owen, Roger G., Cook, Gordon, Drayson, Mark T., Jackson, Graham H., Davies, Faith E., Morgan, Gareth J.

“…We have sequenced 463 presenting cases of myeloma entered into the UK Myeloma XI study using whole exome sequencing. Here we identify mutations induced as a…”
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Monitoring minimal residual disease in the bone marrow using next generation sequencing by Rustad, Even H., Boyle, Eileen M.

“…Achieving minimal residual disease (MRD) negativity in the bone marrow is one of the strongest prognostic factors in multiple myeloma. Consequently, MRD…”
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Copy number signatures predict chromothripsis and clinical outcomes in newly diagnosed multiple myeloma by Maclachlan, Kylee H., Rustad, Even H., Derkach, Andriy, Zheng-Lin, Binbin, Yellapantula, Venkata, Diamond, Benjamin, Hultcrantz, Malin, Ziccheddu, Bachisio, Boyle, Eileen M., Blaney, Patrick, Bolli, Niccolò, Zhang, Yanming, Dogan, Ahmet, Lesokhin, Alexander M., Morgan, Gareth J., Landgren, Ola, Maura, Francesco

“…Chromothripsis is detectable in 20–30% of newly diagnosed multiple myeloma (NDMM) patients and is emerging as a new independent adverse prognostic factor. In…”
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Daratumumab is effective in the relapsed or refractory systemic light‐chain amyloidosis but associated with high infection burden in a frail real‐life population by Van de Wyngaert, Zoe, Carpentier, Benjamin, Pascal, Laurent, Lionne‐Huyghe, Pauline, Leduc, Isabelle, Srour, Micha, Vasseur, Michele, Demarquette, Helene, Terriou, Louis, Herbaux, Charles, Manier, Salomon, Bossard, Jean‐Baptiste, Barbieux, Sarah, Chauvet, Paul, Willaume, Alexandre, Nudel, Morgane, Bories, Claire, Gibier, Jean‐Baptiste, Facon, Thierry, Boyle, Eileen M.

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Reconstructing the evolutionary history of multiple myeloma by Maura, Francesco, Rustad, Even H., Boyle, Eileen M., Morgan, Gareth J.

“…Multiple myeloma is the second most common lymphoproliferative disorder, characterized by aberrant expansion of monoclonal plasma cells. In the last years,…”
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Inflammation and infection in plasma cell disorders: how pathogens shape the fate of patients by Caro, Jessica, Braunstein, Marc, Williams, Louis, Bruno, Benedetto, Kaminetzky, David, Siegel, Ariel, Razzo, Beatrice, Alfandari, Serge, Morgan, Gareth J., Davies, Faith E., Boyle, Eileen M.

“…The role of infection and chronic inflammation in plasma cell disorders (PCD) has been well-described. Despite not being a diagnostic criterion, infection is a…”
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Accelerated single cell seeding in relapsed multiple myeloma by Landau, Heather J., Yellapantula, Venkata, Diamond, Benjamin T., Rustad, Even H., Maclachlan, Kylee H., Gundem, Gunes, Medina-Martinez, Juan, Ossa, Juan Arango, Levine, Max F., Zhou, Yangyu, Kappagantula, Rajya, Baez, Priscilla, Attiyeh, Marc, Makohon-Moore, Alvin, Zhang, Lance, Boyle, Eileen M., Ashby, Cody, Blaney, Patrick, Patel, Minal, Zhang, Yanming, Dogan, Ahmet, Chung, David J., Giralt, Sergio, Lahoud, Oscar B., Peled, Jonathan U., Scordo, Michael, Shah, Gunjan, Hassoun, Hani, Korde, Neha S., Lesokhin, Alexander M., Lu, Sydney, Mailankody, Sham, Shah, Urvi, Smith, Eric, Hultcrantz, Malin L., Ulaner, Gary A., van Rhee, Frits, Morgan, Gareth J., Landgren, Ola, Papaemmanuil, Elli, Iacobuzio-Donahue, Christine, Maura, Francesco

“…Multiple myeloma (MM) progression is characterized by the seeding of cancer cells in different anatomic sites. To characterize this evolutionary process, we…”
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Differential RNA splicing as a potentially important driver mechanism in multiple myeloma by Bauer, Michael A, Ashby, Cody, Wardell, Christopher, Boyle, Eileen M, Ortiz, Maria, Flynt, Erin, Thakurta, Anjan, Morgan, Gareth, Walker, Brian A

“…Disruption of the normal splicing patterns of RNA is a major factor in the pathogenesis of a number of diseases. Increasingly research has shown the strong…”
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The spectrum of somatic mutations in monoclonal gammopathy of undetermined significance indicates a less complex genomic landscape than that in multiple myeloma by Mikulasova, Aneta, Wardell, Christopher P, Murison, Alexander, Boyle, Eileen M, Jackson, Graham H, Smetana, Jan, Kufova, Zuzana, Pour, Ludek, Sandecka, Viera, Almasi, Martina, Vsianska, Pavla, Gregora, Evzen, Kuglik, Petr, Hajek, Roman, Davies, Faith E, Morgan, Gareth J, Walker, Brian A

“…Monoclonal gammopathy of undetermined significance is a pre-malignant precursor of multiple myeloma with a 1% risk of progression per year. Although targeted…”
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Genomic Classification and Individualized Prognosis in Multiple Myeloma by Maura, Francesco, Rajanna, Arjun Raj, Ziccheddu, Bachisio, Poos, Alexandra M, Derkach, Andriy, Maclachlan, Kylee, Durante, Michael, Diamond, Benjamin, Papadimitriou, Marios, Davies, Faith, Boyle, Eileen M, Walker, Brian, Hultcrantz, Malin, Silva, Ariosto, Hampton, Oliver, Teer, Jamie K, Siegel, Erin M, Bolli, Niccolò, Jackson, Graham H, Kaiser, Martin, Pawlyn, Charlotte, Cook, Gordon, Kazandjian, Dickran, Stein, Caleb, Chesi, Marta, Bergsagel, Leif, Mai, Elias K, Goldschmidt, Hartmut, Weisel, Katja C, Fenk, Roland, Raab, Marc S, Van Rhee, Fritz, Usmani, Saad, Shain, Kenneth H, Weinhold, Niels, Morgan, Gareth, Landgren, Ola

“…Outcomes for patients with newly diagnosed multiple myeloma (NDMM) are heterogenous, with overall survival (OS) ranging from months to over 10 years. To…”
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Bartonellosis mimicking post-transplant lymphoproliferative diseases by Boyle, Eileen M, Baillet, Clio, Dupré, Céline, Lassailly, Guillaume, Vuotto, Fanny, Hazzan, Marc, Terriou, Louis, Morschhauser, Franck, Lionet, Arnaud, Frimat, Marie

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Ibrutinib monotherapy in relapsed/refractory CNS lymphoma: A retrospective case series by Chamoun, Kamal, Choquet, Sylvain, Boyle, Eileen, Houillier, Caroline, Larrieu-Ciron, Delphine, Al Jijakli, Ahmad, Delrieu, Vanessa, Delwail, Vincent, Morschhauser, Franck, Hoang-Xuan, Khê, Soussain, Carole

“…Therapeutic improvements are required for primary CNS lymphoma (PCNSL) and secondary CNS lymphoma. PCNSLs are predominantly diffuse large B-cell lymphoma…”
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The Spectrum and Clinical Impact of Epigenetic Modifier Mutations in Myeloma by Pawlyn, Charlotte, Kaiser, Martin F, Heuck, Christoph, Melchor, Lorenzo, Wardell, Christopher P, Murison, Alex, Chavan, Shweta S, Johnson, David C, Begum, Dil B, Dahir, Nasrin M, Proszek, Paula Z, Cairns, David A, Boyle, Eileen M, Jones, John R, Cook, Gordon, Drayson, Mark T, Owen, Roger G, Gregory, Walter M, Jackson, Graham H, Barlogie, Bart, Davies, Faith E, Walker, Brian A, Morgan, Gareth J

“…Epigenetic dysregulation is known to be an important contributor to myeloma pathogenesis but, unlike other B-cell malignancies, the full spectrum of somatic…”
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