Search Results - "Boyer, Meghan E"

Gata2 cis-element is required for hematopoietic stem cell generation in the mammalian embryo by Gao, Xin, Johnson, Kirby D, Chang, Yuan-I, Boyer, Meghan E, Dewey, Colin N, Zhang, Jing, Bresnick, Emery H

“…The generation of hematopoietic stem cells (HSCs) from hemogenic endothelium within the aorta, gonad, mesonephros (AGM) region of the mammalian embryo is…”
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Establishing a hematopoietic genetic network through locus-specific integration of chromatin regulators by DeVilbiss, Andrew W, Boyer, Meghan E, Bresnick, Emery H

“…The establishment and maintenance of cell type-specific transcriptional programs require an ensemble of broadly expressed chromatin remodeling and modifying…”
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Molecular basis of crosstalk between oncogenic Ras and the master regulator of hematopoiesis GATA-2 by Katsumura, Koichi R, Yang, Chenxi, Boyer, Meghan E, Li, Lingjun, Bresnick, Emery H

“…Disease mutations provide unique opportunities to decipher protein and cell function. Mutations in the master regulator of hematopoiesis GATA‐2 underlie an…”
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Mechanism governing a stem cell-generating cis-regulatory element by Sanalkumar, Rajendran, Johnson, Kirby D., Gao, Xin, Boyer, Meghan E., Chang, Yuan-I, Hewitt, Kyle J, Zhang, Jing, Bresnick, Emery H.

“…The unremitting demand to replenish differentiated cells in tissues requires efficient mechanisms to generate and regulate stem and progenitor cells. Although…”
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GATA-1-Dependent Transcriptional Repression of GATA-2 via Disruption of Positive Autoregulation and Domain-Wide Chromatin Remodeling by Grass, Jeffrey A., Boyer, Meghan E., Pal, Saumen, Wu, Jing, Weiss, Mitchell J., Bresnick, Emery H.

“…Interplay among GATA transcription factors is an important determinant of cell fate during hematopoiesis. Although GATA-2 regulates hematopoietic stem cell…”
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Controlling Hematopoiesis through Sumoylation-Dependent Regulation of a GATA Factor by Lee, Hsiang-Ying, Johnson, Kirby D., Fujiwara, Tohru, Boyer, Meghan E., Kim, Shin-Il, Bresnick, Emery H.

“…GATA factors establish transcriptional networks that control fundamental developmental processes. Whereas the regulator of hematopoiesis GATA-1 is subject to…”
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Molecular Hallmarks of Endogenous Chromatin Complexes Containing Master Regulators of Hematopoiesis by Wozniak, Ryan J., Keles, Sunduz, Lugus, Jesse J., Young, Ken H., Boyer, Meghan E., Tran, Tuan M., Choi, Kyunghee, Bresnick, Emery H.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Chromatin Domain Activation via GATA-1 Utilization of a Small Subset of Dispersed GATA Motifs within a Broad Chromosomal Region by Im, Hogune, Grass, Jeffrey A., Johnson, Kirby D., Shin-Il Kim, Boyer, Meghan E., Imbalzano, Anthony N., Bieker, James J., Bresnick, Emery H.

“…Cis elements that mediate transcription factor binding are abundant within genomes, but the rules governing occupancy of such motifs in chromatin are not…”
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Friend of GATA-1–independent transcriptional repression: a novel mode of GATA-1 function by Johnson, Kirby D., Boyer, Meghan E., Kang, Jeong-Ah, Wickrema, Amittha, Cantor, Alan B., Bresnick, Emery H.

“…The GATA-1–interacting protein Friend Of GATA-1 (FOG-1) is essential for the proper transcriptional activation and repression of numerous GATA-1 target genes…”
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Coregulator-Dependent Facilitation of Chromatin Occupancy by GATA-1 by Pal, Saumen, Cantor, Alan B., Johnson, Kirby D., Moran, Tyler B., Boyer, Meghan E., Orkin, Stuart H., Bresnick, Emery H.

“…Coregulator recruitment by DNA-bound factors results in chromatin modification and protein-protein interactions, which regulate transcription. However, the…”
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Dynamic GATA Factor Interplay at a Multicomponent Regulatory Region of the GATA-2 Locus by Martowicz, Melissa L., Grass, Jeffrey A., Boyer, Meghan E., Guend, Hamza, Bresnick, Emery H.

“…Given the simplicity of the DNA sequence that mediates binding of GATA transcription factors, GATA motifs reside throughout chromosomal DNA. However, chromatin…”
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Differential GATA Factor Stabilities:  Implications for Chromatin Occupancy by Structurally Similar Transcription Factors by Lurie, Louis J, Boyer, Meghan E, Grass, Jeffrey A, Bresnick, Emery H

“…Whereas the transcription factors GATA-1 and GATA-2 function both uniquely and redundantly to control blood cell development, the process termed hematopoiesis,…”
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Cooperative Activities of Hematopoietic Regulators Recruit RNA Polymerase II to a Tissue-Specific Chromatin Domain by Johnson, Kirby D., Grass, Jeffrey A., Boyer, Meghan E., Kiekhaefer, Carol M., Blobel, Gerd A., Weiss, Mitchell J., Bresnick, Emery H.

“…The hematopoietic transcription factor GATA-1 regulates erythropoiesis and β-globin expression. Although consensus GATA-1 binding sites exist throughout the…”
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Hematopoietic-Specific Activators Establish an Overlapping Pattern of Histone Acetylation and Methylation within a Mammalian Chromatin Domain by Kiekhaefer, Carol M., Grass, Jeffrey A., Johnson, Kirby D., Boyer, Meghan E., Bresnick, Emery H.

“…Posttranslational modification of histones through acetylation, methylation, and phosphorylation is a common mode of regulating chromatin structure and,…”
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antiangiogenic neurokinin-B/thromboxane A2 regulatory axis by Pal, Saumen, Wu, Jing, Murray, Justin K, Gellman, Samuel H, Wozniak, Michele A, Keely, Patricia J, Boyer, Meghan E, Gomez, Timothy M, Hasso, Sean M, Fallon, John F, Bresnick, Emery H

“…Establishment of angiogenic circuits that orchestrate blood vessel development and remodeling requires an exquisite balance between the activities of pro- and…”
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Cis-element mutated in GATA2-dependent immunodeficiency governs hematopoiesis and vascular integrity by Johnson, Kirby D, Hsu, Amy P, Ryu, Myung-Jeom, Wang, Jinyong, Gao, Xin, Boyer, Meghan E, Liu, Yangang, Lee, Youngsook, Calvo, Katherine R, Keles, Sunduz, Zhang, Jing, Holland, Steven M, Bresnick, Emery H

“…Haploinsufficiency for GATA2 causes human immunodeficiency syndromes characterized by mycobacterial infection, myelodysplasia, lymphedema, or aplastic anemia…”
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Relocalizing Genetic Loci into Specific Subnuclear Neighborhoods by Lee, Hsiang-Ying, Johnson, Kirby D., Boyer, Meghan E., Bresnick, Emery H.

“…A poorly understood problem in genetics is how the three-dimensional organization of the nucleus contributes to establishment and maintenance of…”
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A WW Domain-binding Motif within the Activation Domain of the Hematopoietic Transcription Factor NF-E2 Is Essential for Establishment of a Tissue-specific Histone Modification Pattern by Kiekhaefer, Carol M., Boyer, Meghan E., Johnson, Kirby D., Bresnick, Emery H.

“…Histone H3 methylated at lysine 4 (H3-meK4) co-localizes with hyperacetylated histones H3 and H4 in transcriptionally active chromatin, but mechanisms that…”
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Context-dependent GATA Factor Function: COMBINATORIAL REQUIREMENTS FOR TRANSCRIPTIONAL CONTROL IN HEMATOPOIETIC AND ENDOTHELIAL CELLS by Wozniak, Ryan J, Boyer, Meghan E, Grass, Jeffrey A, Lee, Youngsook, Bresnick, Emery H

“…GATA factors are fundamental components of developmentally important transcriptional networks. By contrast to common mechanisms in which transacting factors…”
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Measurement of protein-DNA interactions in vivo by chromatin immunoprecipitation by Im, Hogune, Grass, Jeffrey A, Johnson, Kirby D, Boyer, Meghan E, Wu, Jing, Bresnick, Emery H

“…Elucidating mechanisms controlling nuclear processes requires an understanding of the nucleoprotein structure of genes at endogenous chromosomal loci…”
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