Search Results - "Boyer, Jose L"

Induction of novel agonist selectivity for the ADP-activated P2Y1 receptor versus the ADP-activated P2Y12 and P2Y13 receptors by conformational constraint of an ADP analog by Chhatriwala, Mariya, Ravi, R Gnana, Patel, Roshni I, Boyer, Jose L, Jacobson, Kenneth A, Harden, T Kendall

“…ADP is the cognate agonist of the P2Y1, P2Y12, and P2Y13 receptors. With the goal of identifying a high potency agonist that selectively activates the P2Y1…”
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Purification and functional reconstitution of the human P2Y12 receptor by Bodor, Erik T, Waldo, Gary L, Hooks, Shelley B, Corbitt, James, Boyer, Jose L, Harden, T Kendall

“…The human P2Y12 receptor (P2Y12-R) is a member of the G protein coupled P2Y receptor family, which is intimately involved in platelet physiology. We describe…”
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International Union of Pharmacology LVIII: Update on the P2Y G Protein-Coupled Nucleotide Receptors: From Molecular Mechanisms and Pathophysiology to Therapy by Abbracchio, Maria P, Burnstock, Geoffrey, Boeynaems, Jean-Marie, Barnard, Eric A, Boyer, José L, Kennedy, Charles, Knight, Gillian E, Fumagalli, Marta, Gachet, Christian, Jacobson, Kenneth A, Weisman, Gary A

“…There have been many advances in our knowledge about different aspects of P2Y receptor signaling since the last review published by our International Union of…”
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P2Y₂ receptor activation decreases blood pressure and increases renal Na⁺ excretion by Rieg, Timo, Gerasimova, Maria, Boyer, José L, Insel, Paul A, Vallon, Volker

“…ATP and UTP are endogenous agonists of P2Y(2/4) receptors. To define the in vivo effects of P2Y(2) receptor activation on blood pressure and urinary excretion,…”
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Molecular Recognition of Modified Adenine Nucleotides by the P2Y1-Receptor. 1. A Synthetic, Biochemical, and NMR Approach by Halbfinger, Efrat, Major, Dan T, Ritzmann, Marco, Ubl, Joachim, Reiser, Georg, Boyer, Jose L, Harden, Kendall T, Fischer, Bilha

“…The remarkably high potencies of 2-thioether-adenine nucleotides regarding the activation of the P2Y1-receptor (P2Y1-R) in turkey erythrocyte membranes…”
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Characterization of the UDP-glucose receptor (re-named here the P2Y 14 receptor) adds diversity to the P2Y receptor family by Abbracchio, Maria P, Boeynaems, Jean-Marie, Barnard, Eric A, Boyer, José L, Kennedy, Charles, Miras-Portugal, Maria Teresa, King, Brian F, Gachet, Christian, Jacobson, Kenneth A, Weisman, Gary A, Burnstock, Geoffrey

“…The cloning of a human G-protein-coupled receptor (GPCR) that specifically responds to UDP-glucose and related sugar-nucleotides has been reported recently…”
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Ocular surface distribution and pharmacokinetics of a novel ophthalmic 1% azithromycin formulation by Akpek, Esen Karamursel, Vittitow, Jason, Verhoeven, Rozemarijn S, Brubaker, Kurt, Amar, Thierry, Powell, Kendall D, Boyer, José L, Crean, Christopher

“…To investigate the ocular distribution of 1% azithromycin ophthalmic solution and the effect of polycarbophil-based mucoadhesive formulation on ocular tissue…”
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Identification of potent, selective P2Y-purinoceptor agonists: structure-activity relationships for 2-thioether derivatives of adenosine 5'-triphosphate by Fischer, Bilha, Boyer, Jose L, Hoyle, Charles H. V, Ziganshin, Airat U, Brizzolara, Antonia L, Knight, Gillian E, Zimmet, Jeffrey, Burnstock, Geoffrey, Harden, T. Kendall, Jacobson, Kenneth A

“…Study of P2-purinoceptor subtypes has been difficult due to the lack of potent and selective ligands. With the goal of developing high affinity…”
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Human P2Y1 Receptor:  Molecular Modeling and Site-Directed Mutagenesis as Tools To Identify Agonist and Antagonist Recognition Sites by Moro, Stefano, Guo, Danping, Camaioni, Emidio, Boyer, José L, Harden, T. Kendall, Jacobson, Kenneth A

“…The molecular basis for recognition by human P2Y1 receptors of the novel, competitive antagonist 2‘-deoxy-N 6-methyladenosine 3‘,5‘-bisphosphate (MRS 2179) was…”
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A Randomized, Controlled Comparison of NCX 470 (0.021%, 0.042%, and 0.065%) and Latanoprost 0.005% in Patients With Open-angle Glaucoma or Ocular Hypertension: The Dolomites Study by Walters, Thomas R., Kothe, Angela C., Boyer, José L., Usner, Dale W., Lopez, Krisol, Duquesroix, Brigitte, Fechtner, Robert D., Navratil, Tomas

“…NCX 470 0.042% and 0.065% were statistically superior in intraocular pressure (IOP) lowering to latanoprost 0.005%, and NCX 470 0.021% was noninferior. All NCX…”
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Rapid and reversible modulation of platelet function in man by a novel P2Y(12) ADP-receptor antagonist, INS50589 by Johnson, Fred L, Boyer, José L, Leese, Philip T, Crean, Christopher, Krishnamoorthy, Ramesh, Durham, Todd, Fox, Anthony W, Kellerman, Donald J

“…P2Y(12) receptors participate in ADP-induced activation and aggregation of human platelets. INS50589, a selective P2Y(12) receptor antagonist, is being…”
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Avian and human homologues of the P2Y1 receptor: Pharmacological, signaling, and molecular properties by Boyer, Jose L., Schachter, Joel B., Sromek, Susan M., Palmer, R. Kyle, Jacobson, Kenneth A., Nicholas, Robert A., Harden, T. Kendall

“…The P2Y receptor on turkey erythrocyte membranes was the first P2 receptor to be shown to activate phospholipase C (PLC) in a strictly guanine…”
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2-Thioether 5‘-O-(1-Thiotriphosphate)adenosine Derivatives as New Insulin Secretagogues Acting through P2Y-Receptors by Fischer, Bilha, Chulkin, Ana, Boyer, Jose L, Harden, Kendall T, Gendron, Fernand-Pierre, Beaudoin, Adrien R, Chapal, Jeannie, Hillaire-Buys, Dominique, Petit, Pierre

“…P2-Receptors (P2-Rs) represent significant targets for novel drug development. P2-Rs were identified also on pancreatic B cells and are involved in insulin…”
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Functional expression of a cDNA encoding a human ecto‐ATPase by Mateo, Jesús, Harden, T Kendall, Boyer, José L

“…The metabolism of extracellular nucleotides plays an important role in nucleotide signalling mediated by P2 receptors. The nucleotide sequence encoding a…”
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Lipophilic Modifications to Dinucleoside Polyphosphates and Nucleotides that Confer Antagonist Properties at the Platelet P2Y12 Receptor by Douglass, James G, Patel, Roshni I, Yerxa, Benjamin R, Shaver, Sammy R, Watson, Paul S, Bednarski, Krzysztof, Plourde, Robert, Redick, Catherine C, Brubaker, Kurt, Jones, Arthur C, Boyer, José L

“…Platelet P2Y12 receptors play a central role in the regulation of platelet function and inhibition of this receptor by treatment with drugs such as clopidogrel…”
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Regulation of P2Y1 receptor-mediated signaling by the ectonucleoside triphosphate diphosphohydrolase isozymes NTPDase1 and NTPDase2 by Alvarado-Castillo, Claudia, Harden, T Kendall, Boyer, José L

“…Ectonucleoside triphosphate diphosphohydrolases (NTPDases) control the concentration of released extracellular nucleotides, but the precise physiological roles…”
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Structure-activity relationships of dinucleotides: Potent and selective agonists of P2Y receptors by Shaver, Sammy R, Rideout, Janet L, Pendergast, William, Douglass, James G, Brown, Edward G, Boyer, José L, Patel, Roshni I, Redick, Catherine C, Jones, Arthur C, Picher, Maryse, Yerxa, Benjamin R

“…Dinucleoside polyphosphates act as agonists on purinergic P2Y receptors to mediate a variety of cellular processes. Symmetrical, naturally occurring purine…”
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Methanocarba Modification of Uracil and Adenine Nucleotides:  High Potency of Northern Ring Conformation at P2Y1, P2Y2, P2Y4, and P2Y11 but Not P2Y6 Receptors by Kim, Hak Sung, Ravi, R. Gnana, Marquez, Victor E, Maddileti, Savitri, Wihlborg, Anna-Karin, Erlinge, David, Malmsjö, Malin, Boyer, José L, Harden, T. Kendall, Jacobson, Kenneth A

“…The potency of nucleotide antagonists at P2Y1 receptors was enhanced by replacing the ribose moiety with a constrained carbocyclic ring (Nandanan, et al. J…”
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Adenine Nucleotide Analogues Locked in a Northern Methanocarba Conformation:  Enhanced Stability and Potency as P2Y1 Receptor Agonists by Ravi, R. Gnana, Kim, Hak Sung, Servos, Jörg, Zimmermann, Herbert, Lee, Kyeong, Maddileti, Savitri, Boyer, José L, Harden, T. Kendall, Jacobson, Kenneth A

“…Preference for the Northern (N) ring conformation of the ribose moiety of nucleotide 5‘-triphosphate agonists at P2Y1, P2Y2, P2Y4, and P2Y11 receptors, but not…”
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Synthesis, Biological Activity, and Molecular Modeling of Ribose-Modified Deoxyadenosine Bisphosphate Analogues as P2Y1 Receptor Ligands by Nandanan, Erathodiyil, Jang, Soo-Yeon, Moro, Stefano, Kim, Hea Ok, Siddiqui, Maqbool A, Russ, Pamela, Marquez, Victor E, Busson, Roger, Herdewijn, Piet, Harden, T. Kendall, Boyer, José L, Jacobson, Kenneth A

“…The structure−activity relationships of adenosine-3‘,5‘-bisphosphates as P2Y1 receptor antagonists have been explored, revealing the potency-enhancing effects…”
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