Search Results - "Boyer, JD"

P16-36. Functional genomic immune profile of SIV DNA vaccines delivered by electroporation and combined with molecular adjuvants by Boyer, JD, Yin, J, Dai, A, Belisle, S, Hirao, L, Palermo, R, Hokey, D, Yan, J, Weiner, D

“…Results The most extraordinary result was that the RANTES molecule dampened the vaccine specific peripheral immune responses as assessed by antigen specific…”
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P19-49. Modulation of vaccine induced responses through CTLA-4 and 41BB enhances protection in macaques following SIVmac251 challenge by Hirao, LA, Hokey, DA, Weber, J, Yan, J, Boyer, JD, Dai, A, Anderson, H, Lewis, M, Jure-Kunkel, MN, Weiner, DB

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P03-11. DNA vaccination with IL-12 lowers viral replication following SIVmac251 challenge by Hirao, LA, Wu, L, Khan, AS, Dai, A, Karl, J, Lank, S, Wiseman, R, O'Connor, D, Watkins, D, Miller, N, Betts, MR, Sardesai, NY, Boyer, JD, Weiner, DB

“…Results Viral loads were followed out 35 weeks post-infection and area under the curve analysis revealed that the DNA and the DNA+12 group had a significant…”
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Local control of primary Merkel cell carcinoma: Review of 45 cases treated with Mohs micrographic surgery with and without adjuvant radiation by Boyer, John D., Zitelli, John A., Brodland, David G., D'Angelo, Gina

“…Background: Optimal treatment of primary Merkel cell carcinoma (MCC) is unknown. High local recurrence rates after excision alone compel some physicians to…”
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Coimmunization with an Optimized IL-15 Plasmid Results in Enhanced Function and Longevity of CD8 T Cells That Are Partially Independent of CD4 T Cell Help by Kutzler, Michele A, Robinson, Tara M, Chattergoon, Michael A, Choo, Daniel K, Choo, Andrew Y, Choe, Philip Y, Ramanathan, Mathura P, Parkinson, Rose, Kudchodkar, Sagar, Tamura, Yutaka, Sidhu, Maninder, Roopchand, Vidia, Kim, J. Joseph, Pavlakis, George N, Felber, Barbara K, Waldmann, Thomas A, Boyer, Jean D, Weiner, David B

“…DNA vaccines are a promising technology for the induction of Ag-specific immune responses, and much recent attention has gone into improving their immune…”
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Fourier-domain angle-resolved low coherence interferometry through an endoscopic fiber bundle for light-scattering spectroscopy by Pyhtila, John W, Boyer, Jeffrey D, Chalut, Kevin J, Wax, Adam

“…We present a novel endoscopic fiber bundle probe incorporated in a Fourier-domain angle-resolved low coherence interferometry system for the measurement of…”
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First Human Trial of a DNA-Based Vaccine for Treatment of Human Immunodeficiency Virus Type 1 Infection: Safety and Host Response by MacGregor, Rob Roy, Boyer, Jean D., Ugen, Kenneth E., Lacy, Kim E., Gluckman, Stephen J., Bagarazzi, Mark L., Chattergoon, Michael A., Baine, Yaela, Higgins, Terry J., Ciccarelli, Richard B., Coney, Leslie R., Ginsberg, Richard S., Weiner, David B.

“…A DNA-based vaccine containing human immunodeficiency virus type 1 (HIV-1) env and rev genes was tested for safety and host immune response in 15 asymptomatic…”
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In vivo engineering of a cellular immune response by coadministration of IL-12 expression vector with a DNA immunogen by Kim, JJ, Ayyavoo, V, Bagarazzi, ML, Chattergoon, MA, Dang, K, Wang, B, Boyer, JD, Weiner, DB

“…Recent studies support the importance of investigating a DNA vaccination approach for the immunologic control of HIV-1. In this regard, it may be important to…”
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Protection of chimpanzees from high-dose heterologous HIV-1 challenge by DNA vaccination by Boyer, Jean D, Ugen, Kenneth E, Wang, Bin, Agadjanyan, Michael, Gilbert, Lori, Bagarazzi, Mark L, Chattergoon, Michael, Frost, Patrice, Javadian, Ali, Williams, Williams V, Refaeli, Yosef, Ciccarelli, Richard B, Mccallus, Daniel, coney, Leslie, Weiner, David B

“…Novel approaches for the generation of more effective vaccines for HIV-1 are of significant importance. In this report we analyze the immunogenicity and…”
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T-cell responses induced in normal volunteers immunized with a DNA-based vaccine containing HIV-1 env and rev by MACGREGOR, Rob Roy, GINSBERG, Richard, UGEN, Kenneth E, BAINE, Yaela, KANG, Christina U, TU, Xin M, HIGGINS, Terry, WEINER, David B, BOYER, Jean D

“…An effective HIV-1 vaccine will likely need to induce strong cell-mediated immunity in humans. Therefore, we examined the ability of a DNA HIV-1 vaccine to…”
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Specific Immune Induction Following DNA-Based Immunization Through In Vivo Transfection and Activation of Macrophages/Antigen-Presenting Cells by Chattergoon, Michael A, Robinson, Tara M, Boyer, Jean D, Weiner, David B

“…The initiation of an adaptive immune response requires Ag presentation in combination with the appropriate activation signals. Classically, Ag presentation and…”
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CD8 positive T cells influence antigen-specific immune responses through the expression of chemokines by Kim, J J, Nottingham, L K, Sin, J I, Tsai, A, Morrison, L, Oh, J, Dang, K, Hu, Y, Kazahaya, K, Bennett, M, Dentchev, T, Wilson, D M, Chalian, A A, Boyer, J D, Agadjanyan, M G, Weiner, D B

“…The potential roles of CD8(+) T-cell-induced chemokines in the expansion of immune responses were examined using DNA immunogen constructs as model antigens. We…”
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Resiquimod is a modest adjuvant for HIV-1 gag-based genetic immunization in a mouse model by Otero, Miguel, Calarota, Sandra A., Felber, Barbara, Laddy, Dominic, Pavlakis, George, Boyer, Jean D., Weiner, David B.

“…DNA vaccines have been effective at generating useful immune responses in many animal species. However, it is clearly desirable to increase their potency. The…”
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Modulating the immune response to genetic immunization by Cohen, Adam. D., Boyer, Jean D., Weiner, David B.

“…ABSTRACT Genetic immunization, also known as DNA or polynucleotide immunization, is a novel strategy for vaccine development in which plasmid DNA encoding…”
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Vaccination of Seronegative Volunteers with a Human Immunodeficiency Virus Type 1 env/rev DNA Vaccine Induces Antigen-Specific Proliferation and Lymphocyte Production of β-Chemokines by Boyer, Jean D., Cohen, Adam D., Vogt, Suzanne, Schumann, Kristen, Nath, Brett, Ahn, Lois, Lacy, Kim, Bagarazzi, Mark L., Higgins, Terry J., Baine, Yaela, Ciccarelli, Richard B., Ginsberg, Richard S., MacGregor, Rob Roy, Weiner, David B.

“…There is a pressing need to test novel vaccine concepts in an effort to develop an effective vaccine for human immunodeficiency virus (HIV) type 1. A phase I…”
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Modulation of amplitude and direction of in vivo immune responses by co‐administration of cytokine gene expression cassettes with DNA immunogens by Kim, Jong J., Trivedi, Neil N., Nottingham, Liesl K., Morrison, Lake, Tsai, Anthony, Hu, Yin, Mahalingam, Sundarasamy, Dang, Kesen, Ahn, Lois, Doyle, Nicole K., Wilson, Darren M., Chattergoon, Michael A., Chalian, Ara A., Boyer, Jean D., Agadjanyan, Michael G., Weiner, David B.

“…Immunization with nucleic acids has been shown to induce both antigen‐specific cellular and humoral immune responses in vivo. We hypothesize that immunization…”
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SIV DNA vaccine co-administered with IL-12 expression plasmid enhances CD8 SIV cellular immune responses in cynomolgus macaques by Boyer, Jean D., Robinson, Tara M., Kutzler, Michele A., Parkinson, R., Calarota, Sandra A., Sidhu, Maninder K., Muthumani, Karuppiah, Lewis, Mark, Pavlakis, George, Felber, Barbara, Weiner, David

“…:  Current evidence suggests that a strong induced CD8 human immunodeficiency virus type 1 (HIV‐1)‐specific cell mediated immune response may be an important…”
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In Vivo Modulation of Vaccine-Induced Immune Responses toward a Th1 Phenotype Increases Potency and Vaccine Effectiveness in a Herpes Simplex Virus Type 2 Mouse Model by Sin, J I, Kim, J J, Boyer, J D, Ciccarelli, R B, Higgins, T J, Weiner, D B

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Priming with plasmid DNAs expressing interleukin-12 and simian immunodeficiency virus gag enhances the immunogenicity and efficacy of an experimental AIDS vaccine based on recombinant vesicular stomatitis virus by Egan, Michael A, Chong, Siew Yen, Megati, Shakuntala, Montefiori, David C, Rose, Nina F, Boyer, Jean D, Sidhu, Maninder K, Quiroz, Jorge, Rosati, Margherita, Schadeck, Eva B, Pavlakis, George N, Weiner, David B, Rose, John K, Israel, Zimra R, Udem, Stephen A, Eldridge, John H

“…Of the various approaches being developed as prophylactic HIV vaccines, those based on a heterologous plasmid DNA prime, live vector boost vaccination regimen…”
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DNA prime Listeria boost induces a cellular immune response to SIV antigens in the rhesus macaque model that is capable of limited suppression of SIV239 viral replication by Boyer, Jean D., Robinson, Tara M., Maciag, Paulo C., Peng, Xiaohui, Johnson, Ross S., Pavlakis, George, Lewis, Mark G., Shen, Anding, Siliciano, Robert, Brown, Charles R., Weiner, David B., Paterson, Yvonne

“…DNA vaccines and recombinant Listeria monocytogenes that express and secrete SIV Gag and Env antigens were combined in a nonhuman primate prime-boost…”
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