Search Results - "Boyd, Timothy D."

Treatment with Granulocyte-Macrophage Colony-Stimulating Factor Reduces Viral Titers in the Brains of West Nile Virus-Infected Mice and Improves Survival by Stonedahl, Sarah, Leser, J Smith, Clarke, Penny, Potter, Huntington, Boyd, Timothy D, Tyler, Kenneth L

“…West Nile virus (WNV) is the leading cause of epidemic arboviral encephalitis in the United States. As there are currently no proven antiviral therapies or…”
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The innate immune system stimulating cytokine GM-CSF improves learning/memory and interneuron and astrocyte brain pathology in Dp16 Down syndrome mice and improves learning/memory in wild-type mice by Ahmed, Md. Mahiuddin, Wang, Athena Ching-Jung, Elos, Mihret, Chial, Heidi J., Sillau, Stefan, Solano, D. Adriana, Coughlan, Christina, Aghili, Leila, Anton, Paige, Markham, Neil, Adame, Vanesa, Gardiner, Katheleen J., Boyd, Timothy D., Potter, Huntington

“…Down syndrome (DS) is characterized by chronic neuroinflammation, peripheral inflammation, astrogliosis, imbalanced excitatory/inhibitory neuronal function,…”
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Innate Immune System Activation and Neuroinflammation in Down Syndrome and Neurodegeneration: Therapeutic Targets or Partners? by Ahmed, Md Mahiuddin, Johnson, Noah R, Boyd, Timothy D, Coughlan, Christina, Chial, Heidi J, Potter, Huntington

“…Innate immune system activation and inflammation are associated with and may contribute to clinical outcomes in people with Down syndrome (DS),…”
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Safety and efficacy of sargramostim (GM‐CSF) in the treatment of Alzheimer's disease by Potter, Huntington, Woodcock, Jonathan H., Boyd, Timothy D., Coughlan, Christina M., O'Shaughnessy, John R., Borges, Manuel T., Thaker, Ashesh A., Raj, Balaibail A., Adamszuk, Katarzyna, Scott, David, Adame, Vanesa, Anton, Paige, Chial, Heidi J., Gray, Helen, Daniels, Joseph, Stocker, Michelle E., Sillau, Stefan H.

“…Introduction Inflammatory markers have long been observed in the brain, cerebrospinal fluid (CSF), and plasma of Alzheimer's disease (AD) patients, suggesting…”
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Recruiting the innate immune system with GM-CSF to fight viral diseases, including West Nile Virus encephalitis and COVID-19 [version 1; peer review: 1 approved, 2 approved with reservations] by Potter, Huntington, Boyd, Timothy D, Clarke, Penny, Pelak, Victoria S, Tyler, Kenneth L

“…As the coronavirus disease 2019 (COVID-19) pandemic grows throughout the world, it is imperative that all approaches to ameliorating its effects be…”
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Varicella-Zoster Virus Infection of Primary Human Spinal Astrocytes Produces Intracellular Amylin, Amyloid-β, and an Amyloidogenic Extracellular Environment by Bubak, Andrew N, Como, Christina N, Coughlan, Christina M, Johnson, Noah R, Hassell, James E, Mescher, Teresa, Niemeyer, Christy S, Mahalingam, Ravi, Cohrs, Randall J, Boyd, Timothy D, Potter, Huntington, Russ, Holger A, Nagel, Maria A

“…Abstract Background Herpes zoster is linked to amyloid-associated diseases, including dementia, macular degeneration, and diabetes mellitus, in epidemiological…”
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Amylin, Aβ42, and Amyloid in Varicella Zoster Virus Vasculopathy Cerebrospinal Fluid and Infected Vascular Cells by Bubak, Andrew N, Beseler, Cheryl, Como, Christina N, Coughlan, Christina M, Johnson, Noah R, Hassell, James E, Burnet, Anna M, Mescher, Teresa, Schmid, D Scott, Coleman, Colin, Mahalingam, Ravi, Cohrs, Randall J, Boyd, Timothy D, Potter, Huntington, Shilleh, Ali H, Russ, Holger A, Nagel, Maria A

“…Abstract Background Varicella zoster virus (VZV) vasculopathy is characterized by persistent arterial inflammation leading to stroke. Studies show that VZV…”
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Granulocyte‐macrophage colony‐stimulating factor reverses Alzheimer’s disease pathology in the tgf344‐AD rat model by Ahmed, Md. Mahiuddin, Wang, Athena Ching‐Jung, Boyd, Timothy D., Solano, D. Adriana, Vielle, Anne, Markham, Neil, Coughlan, Christina M, Chial, Heidi J, Vergara, M. Natalia, Potter, Huntington

“…Background Granulocyte‐macrophage colony‐stimulating factor (GM‐CSF), a hematopoietic growth factor, has shown therapeutic and neuroprotective effects in…”
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GM-CSF up-regulated in reumatoid arthritis reverses cognitive impairment and amyloidosis in Alzheimer mice by Boyd, Timothy D

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GM‐CSF reduces amylin amyloid, inhibits pancreatic apoptosis, and sustains lowered blood glucose levels in the hIAPP mouse model of Type 2 diabetes mellitus, a known risk factor for Alzheimer’s disease by Wang, Athena Ching‐Jung, Boyd, Timothy D., Adame, Vanesa, Potter, Huntington

“…Background People with Type II diabetes mellitus (T2D) are at higher risk for developing Alzheimer’s disease (AD). T2D is characterized histopathologically by…”
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GM‐CSF reduces amylin amyloid and prevents pancreatic cell death in the hIAPP mouse model of Type 2 diabetes mellitus, a known risk factor for Alzheimer’s disease by Wang, Athena Ching‐Jung, Boyd, Timothy D., Markham, Neil, Adame, Vanesa, Potter, Huntington

“…Background People with Type II diabetes mellitus (T2D) are at higher risk for developing Alzheimer’s disease (AD). T2D is characterized histopathologically by…”
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GM‐CSF Treatment Increases the Number of Purkinje Cells in a Mouse Model of Down Syndrome by Ahmed, Md. Mahiuddin, Aghili, Leila, Wang, Athena Ching‐Jung, Elos, Mihret, Boyd, Timothy D., Chial, Heidi J, Potter, Huntington

“…Background Down syndrome (DS), the most common chromosomal disorder that is a genetic cause of intellectual disability (ID), is characterized by mild‐to‐severe…”
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Granulocyte‐Macrophage Colony‐Stimulating Factor Reduces Two Major Pathological Hallmarks of Alzheimer’s Disease and Astrogliosis in the TgF344‐AD Rat Model by Ahmed, Md. Mahiuddin, Wang, Athena Ching‐Jung, Boyd, Timothy D., Solano, D. Adriana, Vielle, Anne, Markham, Neil, Coughlan, Christina M, Chial, Heidi J, Vergara, M. Natalia, Potter, Huntington

“…Background Granulocyte‐macrophage colony‐stimulating factor (GM‐CSF), a hematopoietic growth factor and the innate immune system modulator, has shown…”
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The Potential Alzheimer’s Disease Drug, GM‐CSF, Enhances the Anti‐Viral Immune Response and Reduces Mortality in a Mouse Model of COVID‐19 by Kendall, Lon V., Boyd, Timothy D., Sillau, Stefan H, Bosco‐Lauth, Angela, Markham, Neil, Fong, Derek, Clarke, Penny, Tyler, Kenneth L., Potter, Huntington

“…Background COVID‐19 results in increased expression of inflammatory cytokines and Alzheimer’s disease (AD) biomarkers of neuronal damage, but…”
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The immune cytokine granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) is an effective treatment for both Alzheimer’s disease and the viral diseases caused by West Nile Virus and SARS‐CoV‐2 infection, indicating that inflammation and viral infection may be partners and therapeutic co‐targets in many brain disorders by Potter, Huntington, Boyd, Timothy D., Woodcock, Jonathan H, Sillau, Stefan H, Ahmed, Md. Mahiuddin, Wang, Athena Ching‐Jung, Chial, Heidi J, Coughlan, Christina M, Kendall, Lon V., Bosco‐Lauth, Angela, Markham, Neil, Stonedahl, Sarah, Fong, Derek, Clarke, Penny, Tyler, Kenneth L.

“…Background GM‐CSF has been considered a potential therapeutic target in many disorders associated with inflammation because it is upregulated and upregulates…”
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Inflammation and innate immune system activation in neurodegeneration, Down syndrome, aging, and infection: Therapeutic target or partner? by Potter, Huntington, Boyd, Timothy D., Ahmed, Md. Mahiuddin, Kendall, Lon V., Sillau, Stefan H, Coughlan, Christina M, Clarke, Penny, Stonedahl, Sarah, Chial, Heidi J

“…Background Characteristic features/biomarkers of innate immune system activation and inflammation are associated with neurodegenerative diseases (e.g.,…”
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Traumatic Brain Injury Exacerbates Retinal Alzheimer’s Disease Histopathology in the TgF344 Rat Model by Vergara, M. Natalia, Secora, Conner N, Vielle, Anne, Wang, Athena Ching‐Jung, Lenhart, Patricia, Salcedo, Ernesto, Johnson, Noah R, Ahmed, Md. Mahiuddin, Chial, Heidi J, Boyd, Timothy D., Potter, Huntington

“…Background Alzheimer’s disease (AD) is a neurodegenerative condition of the central nervous system that affects both the brain and the retina, and can lead to…”
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P3‐419: GM‐CSF up‐regulated in reumatoid arthritis reverses cognitive impairment and amyloidosis in Alzheimer mice by Boyd, Timothy D.

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Dose Measurements to the Contralateral Breast During Accelerated Partial Breast Irradiation, Medial vs Lateral Insertion by Cardarelli, Gene A., PhD, MPH, Steger, Theodore, PhD, Gortney, Janet, MS, Boyd, Timothy, MD, Salner, Andrew, MD

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