Relationship between risk factors for impaired bone health and HR-pQCT in young adults with type 1 diabetes

Relationship between risk factors for impaired bone health and HR-pQCT in young adults with type 1 diabetes

In type 1 diabetes, risk factors associated with impaired bone health contribute to increased risk of fracture. The aim of this study was to (1): compare the high-resolution peripheral quantitative computed tomography (HR-pQCT) parameters of young adults with type 1 diabetes with those of healthy co...

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Published in:Frontiers in endocrinology (Lausanne) Vol. 14; p. 1144137
Main Authors: Sochett, Etienne B, Dominicis, Mary, Vali, Reza, Shammas, Amer, Elia, Yesmino, Moineddin, Rahim, Mahmud, Farid, Assor, Esther, Furman, Michelle, Boyd, Steve K, Lenherr-Taube, Nina
Format: Journal Article
Language:English
Published: Switzerland Frontiers Media S.A 03-03-2023
Subjects:
Adolescent
Bone Density
bone health
Canada
Cross-Sectional Studies
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 1 - diagnostic imaging
Endocrinology
Female
Fractures, Bone
Glycated Hemoglobin
HbA1c (A1C)
HR-pQCT
Humans
Male
Risk Factors
type 1 diabetes
vitamin D
Young Adult
young adults
Canada
HbA1c (A1C)
HR-pQCT
type 1 diabetes
vitamin D
young adults
bone health
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Summary:In type 1 diabetes, risk factors associated with impaired bone health contribute to increased risk of fracture. The aim of this study was to (1): compare the high-resolution peripheral quantitative computed tomography (HR-pQCT) parameters of young adults with type 1 diabetes with those of healthy controls (2), identify sex differences, and (3) evaluate the association between diabetes and bone health risk factors, with HR-pQCT. This is a cross-sectional study in young Canadian adults with childhood onset type 1 diabetes. Z-scores were generated for HR-pQCT parameters using a large healthy control database. Diet, physical activity, BMI, hemoglobin A1C (A1C) and bone health measures were evaluated, and associations were analyzed using multivariate regression analysis. Eighty-eight participants (age 21 ± 2.2 years; 40 males, 48 females, diabetes duration 13.9 ± 3.4 years) with type 1 diabetes were studied. Low trabecular thickness and elevated cortical geometry parameters were found suggesting impaired bone quality. There were no sex differences. Significant associations were found: Vitamin D (25(OH)D) with trabecular parameters with possible synergy with A1C, parathyroid hormone with cortical parameters, BMI with cortical bone and failure load, and diabetes duration with trabecular area. Our data suggests impairment of bone health as assessed by HR-pQCT in young adults with type 1 diabetes. Modifiable risk factors were associated with trabecular and cortical parameters. These findings imply that correction of vitamin D deficiency, prevention and treatment of secondary hyperparathyroidism, and optimization of metabolic control may reduce incident fractures.
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Reviewed by: Matthias Walle, ETH Zürich, Switzerland; Jan Josef Stepan, Charles University, Czechia
Edited by: Giacomina Brunetti, University of Bari Aldo Moro, Italy
This article was submitted to Bone Research, a section of the journal Frontiers in Endocrinology
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2023.1144137