Search Results - "Boyd, R A"

The deposition of strontium and zinc Co-substituted hydroxyapatite coatings by Robinson, L., Salma-Ancane, K., Stipniece, L., Meenan, B. J., Boyd, A. R.

“…The in vitro and in vivo performance of hydroxyapatite (HAp) coatings can be modified by the addition of different trace ions, such as silicon (Si), lithium…”
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Model‐Based Meta‐Analysis for Comparative Efficacy and Safety: Application in Drug Development and Beyond by Mandema, J W, Gibbs, M, Boyd, R A, Wada, D R, Pfister, M

“…High development cost, low development success, cost‐disciplined health‐care policies, and intense competition demand an efficient drug development process…”
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Population Pharmacokinetics, Pharmacodynamics, and Exploratory Exposure–Response Analyses of Apixaban in Subjects Treated for Venous Thromboembolism by Byon, W, Sweeney, K, Frost, C, Boyd, RA

“…Apixaban is approved for treatment of venous thromboembolism (VTE) and prevention of recurrence. Population pharmacokinetics, pharmacokinetics–pharmacodynamics…”
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Model-Based Drug Development: A Rational Approach to Efficiently Accelerate Drug Development by Milligan, P A, Brown, M J, Marchant, B, Martin, S W, van der Graaf, P H, Benson, N, Nucci, G, Nichols, D J, Boyd, R A, Mandema, J W, Krishnaswami, S, Zwillich, S, Gruben, D, Anziano, R J, Stock, T C, Lalonde, R L

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Direct Oral Anticoagulants Vs. Enoxaparin for Prevention of Venous Thromboembolism Following Orthopedic Surgery: A Dose–Response Meta‐analysis by Boyd, RA, DiCarlo, L, Mandema, JW

“…We carried out a dose–response model‐based meta‐analysis to assess venous thromboembolism (VTE) and bleeding with factor Xa (FXa) inhibitors (apixaban,…”
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Therapeutic Index of Anticoagulants for Prevention of Venous Thromboembolism Following Orthopedic Surgery: A Dose–Response Meta‐Analysis by Mandema, J W, Boyd, R A, DiCarlo, L A

“…Information on the comparative effectiveness of drugs is crucial for drug development decisions, in addition to being needed by regulators, prescribers, and…”
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An adaptive‐design dose‐ranging study of PD 0348292, an oral factor Xa inhibitor, for thromboprophylaxis after total knee replacement surgery by Cohen, A. T., Boyd, R. A., Mandema, J. W., DiCarlo, L., Pak, R.

“…Summary Background PD 0348292 is an oral, selective, direct and reversible factor Xa inhibitor. This was an adaptive dose‐ranging study evaluating a 100‐fold…”
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Transporters for Cationic Amino Acids in Animal Cells: Discovery, Structure, and Function by DEVES, R, BOYD, C. A. R

“…R. DEVÉS AND C. A. R. BOYD Programa de Fisiología y Biofísica, Instituto de Ciencias Biomédicas, Universidad de Chile, Santiago, Chile; and Department of Human…”
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Surface characterisation of the evolving nature of radio frequency (RF) magnetron sputter deposited calcium phosphate thin films after exposure to physiological solution by Boyd, A.R., Meenan, B.J., Leyland, N.S.

“…The initial behaviour and ultimately the long-term performance of calcium phosphate (Ca–P) coatings for hard tissue implant applications are influenced by…”
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The influence of target stoichiometry on early cell adhesion of co-sputtered calcium–phosphate surfaces by Boyd, A. R., O’Kane, C., O’Hare, P., Burke, G. A., Meenan, B. J.

“…The nature of the initial interaction between calcium phosphate (Ca–P) thin films and osteoblasts can be influenced by a number of different properties…”
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Modelling apical columnar epithelium mechanics from circumferential contractile fibres by Boyd, A. R. B., Moore, S., Sader, J. E., Lee, P. V. S.

“…Simple columnar epithelia are formed by individual epithelial cells connecting together to form single cell high sheets. They are a main component of many…”
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Nontraditional approaches to first-in-human studies to increase efficiency of drug development: will microdose studies make a significant impact? by Boyd, R A, Lalonde, R L

“…Much has been written recently about low productivity in the pharmaceutical industry and the high cost of drug development.1,2 Over a 10‐year period ending in…”
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Discrete Spatial Optical Solitons in Waveguide Arrays by Eisenberg, H. S., Silberberg, Y., Morandotti, R., Boyd, A. R., Aitchison, J. S.

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Raman spectroscopy of primary bovine aortic endothelial cells: a comparison of single cell and cell cluster analysis by Boyd, A. R., McManus, L. L., Burke, G. A., Meenan, B. J.

“…There are many techniques that allow in vitro interactions among cells and their environment to be monitored, including molecular, biochemical and…”
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Monitoring cellular behaviour using Raman spectroscopy for tissue engineering and regenerative medicine applications by Boyd, A. R., Burke, G. A., Meenan, B. J.

“…Raman spectroscopy has been used to determine the chemical composition of materials for over 70 years. Recent spectacular advances in laser and CCD camera…”
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Sputter deposited bioceramic coatings: surface characterisation and initial protein adsorption studies using surface-MALDI-MS by Boyd, A. R., Burke, G. A., Duffy, H., Holmberg, M., O’ Kane, C., Meenan, B. J., Kingshott, P.

“…Protein adsorption onto calcium phosphate (Ca–P) bioceramics utilised in hard tissue implant applications has been highlighted as one of the key events that…”
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Proton-assisted amino-acid transporters are conserved regulators of proliferation and amino-acid-dependent mTORC1 activation by Heublein, S, Kazi, S, Ögmundsdóttir, M H, Attwood, E V, Kala, S, Boyd, C A R, Wilson, C, Goberdhan, D C I

“…The phosphoinositide3-kinase (PI3K)/Akt and downstream mammalian target of rapamycin complex 1 (mTORC1) signalling cascades promote normal growth and are…”
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Herbicides and herbicide degradates in shallow groundwater and the Cedar River near a municipal well field, Cedar Rapids, Iowa by Boyd, R.A

“…Water samples were collected near a Cedar Rapids, Iowa municipal well field from June 1998 to August 1998 and analyzed for selected triazine and acetanilide…”
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The influence of target stoichiometry on the surface properties of sputter deposited calcium phosphate thin films by O'Kane, C., Duffy, H., Meenan, B.J., Boyd, A.R.

“…A range of calcium phosphate (Ca–P) coatings have been sputter deposited at low deposition power from Ca–P targets with different phase compositions. The…”
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Expression of Sterol Regulatory Element-Binding Protein 1c (SREBP-1c) mRNA in Rat Hepatoma Cells Requires Endogenous LXR Ligands by DeBose-Boyd, Russell A., Ou, Jiafu, Goldstein, Joseph L., Brown, Michael S.

“…The current paper describes a line of cultured rat hepatoma cells (McA-RH7777 cells) that mimics the behavior of rat liver by producing an excess of mRNA for…”
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