Search Results - "Boyd, Lenka"

Heterogeneity and plasticity of cancer-associated fibroblasts in the pancreatic tumor microenvironment by Boyd, Lenka N.C., Andini, Katarina D., Peters, Godefridus J., Kazemier, Geert, Giovannetti, Elisa

“…Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with a notably poor prognosis, in urgent need of improved treatment strategies. The…”
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Factors that influence the pancreatic and duodenal microbiome in patients undergoing pancreatic surgery by Zwart, Eline S, Jeleniewski, Suzanne, Boyd, Lenka N C, Meijer, Laura L, Puik, Jisce R, Zonderhuis, Barbara M, Daams, Freek, Budding, Andries E, Mebius, Reina E, Kazemier, Geert

“…This study examined the correlation between pancreatic microbiome and patients characteristics. Furthermore, we compared different duodenal materials to…”
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NUC-1031 in biliary tract cancer: from bench to bedside and back? by Boyd, Lenka N. C., Peters, Godefridus J., Kazemier, Geert, Giovannetti, Elisa

“…In preclinical models of biliary tract cancer, NUC-1031 showed less potency than gemcitabine, no correlation with potential biomarkers and only moderate…”
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Spatial immune composition of tumor microenvironment in patients with pancreatic cancer by Zwart, Eline S., van Ee, Thomas, Affandi, Alsya J., Boyd, Lenka N. C., Rodriguez, Ernesto, den Haan, Joke M. M., Farina, Arantza, van Grieken, Nicole C. T., Meijer, Laura L., van Kooyk, Yvette, Mebius, Reina E., Kazemier, Geert

“…This study examined the composition of the immune microenvironment at different sites within resected pancreas specimens from patients with pancreatic ductal…”
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hENT1 as a Predictive Biomarker in PDAC-Letter by Boyd, Lenka N C, Ali, Mahsoem, Puik, Jisce R, Meijer, Laura L, Le Large, Tessa Y S, van Laarhoven, Hanneke W M, Giovannetti, Elisa, Kazemier, Geert

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Combined Expression of Plasma Thrombospondin‐2 and CA19‐9 for Diagnosis of Pancreatic Cancer and Distal Cholangiocarcinoma: A Proteome Approach by Le Large, Tessa Y.S., Meijer, Laura L., Paleckyte, Rosita, Boyd, Lenka N.C., Kok, Bart, Wurdinger, Thomas, Schelfhorst, Tim, Piersma, Sander R., Pham, Thang V., Grieken, Nicole C.T., Zonderhuis, Barbara M., Daams, Freek, Laarhoven, Hanneke W.M., Bijlsma, Maarten F., Jimenez, Connie R., Giovannetti, Elisa, Kazemier, Geert

“…Background Minimally invasive diagnostic biomarkers for patients with pancreatic ductal adenocarcinoma (PDAC) and distal cholangiocarcinoma (dCCA) are…”
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The Proteomic Landscape of Pancreatic Ductal Adenocarcinoma Liver Metastases Identifies Molecular Subtypes and Associations with Clinical Response-Letter by Le Large, Tessa Y S, Boyd, Lenka N C, Kazemier, Geert, Giovannetti, Elisa

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In‐depth immune profiling of peripheral blood mononuclear cells in patients with pancreatic ductal adenocarcinoma reveals discriminative immune subpopulations by Rodriguez, Ernesto, Zwart, Eline S., Affandi, Alsya A., Verhoeff, Jan, Kok, Mike, Boyd, Lenka N. C., Meijer, Laura L., Le Large, Tessa Y. S., Olesek, Katarzyna, Giovannetti, Elisa, García‐Vallejo, Juan J., Mebius, Reina E., Kooyk, Yvette, Kazemier, Geert

“…Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis with a 5‐year survival of less than 10%. More knowledge of the immune response developed in…”
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Diagnostic accuracy and added value of blood-based protein biomarkers for pancreatic cancer: a meta-analysis of aggregate and individual participant data by Boyd, Lenka N.C., Ali, Mahsoem, Leeflang, Mariska M.G., Treglia, Giorgio, de Vries, Ralph, Le Large, Tessa Y.S., Besselink, Marc G., Giovannetti, Elisa, van Laarhoven, Hanneke W.M., Kazemier, Geert

“…Novel blood-based protein biomarkers may be of value for efficient, accurate, and non-invasive diagnosis of pancreatic cancer. This study assesses the…”
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Proteomic Analysis of miR-195 and miR-497 Replacement Reveals Potential Candidates that Increase Sensitivity to Oxaliplatin in MSI/P53wt Colorectal Cancer Cells by Poel, Dennis, Boyd, Lenka N C, Beekhof, Robin, Schelfhorst, Tim, Pham, Thang V, Piersma, Sander R, Knol, Jaco C, Jimenez, Connie R, Verheul, Henk M W, Buffart, Tineke E

“…Most patients with advanced colorectal cancer (CRC) eventually develop resistance to systemic combination therapy. miR-195-5p and miR-497-5p are downregulated…”
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Prognostic and predictive value of human equilibrative nucleoside transporter 1 (hENT1) in extrahepatic cholangiocarcinoma: a translational study by Boyd, Lenka N. C., Nooijen, Lynn E., Ali, Mahsoem, Puik, Jisce R., Moustaquim, Jasmine, Fraga Rodrigues, Stephanie M., Broos, Robert, Belkouz, Ali, Meijer, Laura L., Le Large, Tessa Y. S., Erdmann, Joris I., Hooijer, Gerrit K. J., Heger, Michal, Van Laarhoven, Hanneke W. M., Roos, Eva, Kazemier, Geert, Giovannetti, Elisa, Verheij, Joanne, Klümpen, Heinz-Josef

“…Introduction: Effective (neo) adjuvant chemotherapy for cholangiocarcinoma is lacking due to chemoresistance and the absence of predictive biomarkers. Human…”
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The Diagnostic Value of the CA19-9 and Bilirubin Ratio in Patients with Pancreatic Cancer, Distal Bile Duct Cancer and Benign Periampullary Diseases, a Novel Approach by Boyd, Lenka N C, Ali, Mahsoem, Kam, Laura, Puik, Jisce R, Rodrigues, Stephanie M Fraga, Zwart, Eline S, Daams, Freek, Zonderhuis, Barbara M, Meijer, Laura L, Le Large, Tessa Y S, Giovannetti, Elisa, van Laarhoven, Hanneke W M, Kazemier, Geert

“…Distinction of pancreatic ductal adenocarcinoma (PDAC) in the head of the pancreas, distal cholangiocarcinoma (dCCA), and benign periampullary conditions, is…”
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Prediction Model for Early-Stage Pancreatic Cancer Using Routinely Measured Blood Biomarkers by Boyd, Lenka N C, Ali, Mahsoem, Comandatore, Annalisa, Garajova, Ingrid, Kam, Laura, Puik, Jisce R, Fraga Rodrigues, Stephanie M, Meijer, Laura L, Le Large, Tessa Y S, Besselink, Marc G, Morelli, Luca, Frampton, Adam, van Laarhoven, Hanneke W M, Giovannetti, Elisa, Kazemier, Geert

“…Accurate risk prediction models using routinely measured biomarkers-eg, carbohydrate antigen 19-9 (CA19-9) and bilirubin serum levels-for pancreatic cancer…”
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Prognostic value of microRNA-21 in intra- and extrahepatic cholangiocarcinoma after radical resection: cohort study by Boyd, Lenka N C, Ali, Mahsoem, Comandatore, Annalisa, Brandi, Giovanni, Tavolari, Simona, Gaeta, Raffaele, Meijer, Laura L, Le Large, Tessa Y S, Riefolo, Mattia, Vasuri, Francesco, Morelli, Luca, van Laarhoven, Hanneke W M, Giovannetti, Elisa, Kazemier, Geert, Garajová, Ingrid

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Plasma miR-379 can predict treatment response to FOLFIRINOX and gemcitabine-nab-paclitaxel in advanced pancreatic cancer by Boyd, Lenka N.C., Ali, Mahsoem, Puik, Jisce R., Comandatore, Annalisa, Ginocchi, Laura, Meijer, Laura L., Swijnenburg, Rutger-Jan, Tartarini, Roberta, Le Large, Tessa Y.S., Morelli, Luca, Garajova, Ingrid, Besselink, Marc G., Mambrini, Andrea, Wilmink, Johanna W., Frampton, Adam E., van Laarhoven, Hanneke W.M., Giovannetti, Elisa, Kazemier, Geert

“…Background: Novel biomarkers, such as plasma microRNAs (miRs), are needed to help guide clinical decision-making for the type of chemotherapy to use in…”
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Abstract 2588: Restoring downregulated microRNAs miR-195-5p and miR-497-5p increases sensitivity to chemotherapy in colorectal cancer cells by Boyd, Lenka N., Poel, Dennis, Schelfhorst, Tim, Pham, Thang V., Piersma, Sander R., Knol, Jaco C., Jimenez, Connie R., Verheul, Henk M., Buffart, Tineke E.

“…Background: Patients with advanced colorectal cancer (CRC) are commonly treated with systemic combination therapy, however the success of treatment is hampered…”
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To Combine or Not Combine: Drug Interactions and Tools for Their Analysis. Reflections from the EORTC-PAMM Course on Preclinical and Early-phase Clinical Pharmacology by El Hassouni, Btissame, Mantini, Giulia, Li Petri, Giovanna, Capula, Mjriam, Boyd, Lenka, Weinstein, Hannah N W, Vallés-Marti, Andrea, Kouwenhoven, Mathilde C M, Giovannetti, Elisa, Westerman, Bart A, Peters, Godefridus J

“…Combination therapies are used in the clinic to achieve cure, better efficacy and to circumvent resistant disease in patients. Initial assessment of the effect…”
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Association of hypothyroidism with survival in pancreatic cancer: retrospective cohort study by Garajová, Ingrid, Comandatore, Annalisa, Boyd, Lenka, Ali, Mahsoem, Gelsomino, Fabio, de Lorenzo, Stefania, Pedrazzi, Giuseppe, Spallanzani, Andrea, Martinelli, Giulio, Balsano, Rita, Leonardi, Francesco, Palmeri, Matteo, Kazemier, Geert, Di Franco, Gregorio, Guadagni, Simone, Furbetta, Niccolò, Gentiluomo, Manuel, Ramacciotti, Niccolò, Di Candio, Giulio, Giovannetti, Elisa, Morelli, Luca

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Diagnostic accuracy and added value of blood-based protein biomarkers for pancreatic cancer: A meta-analysis of aggregate and individual participant dataResearch in context by Lenka N.C. Boyd, Mahsoem Ali, Mariska M.G. Leeflang, Giorgio Treglia, Ralph de Vries, Tessa Y.S. Le Large, Marc G. Besselink, Elisa Giovannetti, Hanneke W.M. van Laarhoven, Geert Kazemier

“…Background: Novel blood-based protein biomarkers may be of value for efficient, accurate, and non-invasive diagnosis of pancreatic cancer. This study assesses…”
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