Search Results - "Boyd, Ashleigh S."

Lack of Immune Response to Differentiated Cells Derived from Syngeneic Induced Pluripotent Stem Cells by Guha, Prajna, Morgan, John W., Mostoslavsky, Gustavo, Rodrigues, Neil P., Boyd, Ashleigh S.

“…The prospects for using autologous induced pluripotent stem cells (iPSCs) in cell replacement therapy have been tempered by evidence that undifferentiated,…”
Get full text

Zeb1 Regulates the Function of Lympho-Myeloid Primed Progenitors after Transplantation by Almotiri, Alhomidi, Boyd, Ashleigh S., Rodrigues, Neil P.

“…Zeb1, a zinc finger E-box binding homeobox epithelial–mesenchymal (EMT) transcription factor, acts as a critical regulator of hematopoietic stem cell (HSC)…”
Get full text

Gata2 as a Crucial Regulator of Stem Cells in Adult Hematopoiesis and Acute Myeloid Leukemia by Menendez-Gonzalez, Juan Bautista, Vukovic, Milica, Abdelfattah, Ali, Saleh, Lubaid, Almotiri, Alhomidi, Thomas, Leigh-anne, Agirre-Lizaso, Aloña, Azevedo, Aleksandra, Menezes, Ana Catarina, Tornillo, Giusy, Edkins, Sarah, Kong, Kay, Giles, Peter, Anjos-Afonso, Fernando, Tonks, Alex, Boyd, Ashleigh S., Kranc, Kamil R., Rodrigues, Neil P.

“…Subversion of transcription factor (TF) activity in hematopoietic stem/progenitor cells (HSPCs) leads to the development of therapy-resistant leukemic stem…”
Get full text

GATA-2 regulates granulocyte-macrophage progenitor cell function by Rodrigues, Neil P., Boyd, Ashleigh S., Fugazza, Cristina, May, Gillian E., Guo, YanPing, Tipping, Alex J., Scadden, David T., Vyas, Paresh, Enver, Tariq

“…The zinc finger transcription factor GATA-2 has been implicated in the regulation of hematopoietic stem cells. Herein, we explored the role of GATA-2 as a…”
Get full text

Characteristics of the early immune response following transplantation of mouse ES cell derived insulin-producing cell clusters by Boyd, Ashleigh S, Wood, Kathryn J

“…The fully differentiated progeny of ES cells (ESC) may eventually be used for cell replacement therapy (CRT). However, elements of the innate immune system may…”
Get full text

Dickkopf-3, a tissue-derived modulator of local T-cell responses by Meister, Michael, Papatriantafyllou, Maria, Nordström, Viola, Kumar, Varun, Ludwig, Julia, Lui, Kathy O, Boyd, Ashleigh S, Popovic, Zoran V, Fleming, Thomas Henry, Moldenhauer, Gerhard, Nawroth, Peter P, Gröne, Hermann-Josef, Waldmann, Herman, Oelert, Thilo, Arnold, Bernd

“…The adaptive immune system protects organisms from harmful environmental insults. In parallel, regulatory mechanisms control immune responses in order to…”
Get full text

Variation in MHC Expression Between Undifferentiated Mouse ES Cells and ES Cell-derived Insulin-producing Cell Clusters by BOYD, Ashleigh S, WOOD, Kathryn J

“…The progeny of embryonic stem (ES) cells may eventually be used to replace damaged tissues in transplantation, yet their immunogenicity remains ill-defined…”
Get full text

Zeb1 modulates hematopoietic stem cell fates required for suppressing acute myeloid leukemia by Almotiri, Alhomidi, Alzahrani, Hamed, Menendez-Gonzalez, Juan Bautista, Abdelfattah, Ali, Alotaibi, Badi, Saleh, Lubaid, Greene, Adelle, Georgiou, Mia, Gibbs, Alex, Alsayari, Amani, Taha, Sarab, Thomas, Leigh-Anne, Shah, Dhruv, Edkins, Sarah, Giles, Peter, Stemmler, Marc P, Brabletz, Simone, Brabletz, Thomas, Boyd, Ashleigh S, Siebzehnrubl, Florian A, Rodrigues, Neil P

“…Zeb1, a zinc finger E-box binding homeobox epithelial-mesenchymal transition (EMT) transcription factor, confers properties of "stemness," such as…”
Get full text

Decellularization of Mouse Kidneys to Generate an Extracellular Matrix Gel for Human Induced Pluripotent Stem Cell Derived Renal Organoids by Nag, Sparshita, Boyd, Ashleigh S.

“…Chronic Kidney Disease (CKD) is a major cause of morbidity and mortality characterized by progressive renal fibrosis, and in extreme cases, renal failure…”
Get full text

Stem Cells Cycle toward Immune Surveillance by Boyd, Ashleigh S., Rodrigues, Neil P.

“…Immune surveillance is an established regulatory mechanism that spares tissues from malignant transformation. Agudo et al. (2018) find that the chief cell type…”
Get full text

An alginate-based encapsulation system for delivery of therapeutic cells to the CNS by Eleftheriadou, Despoina, Evans, Rachael E, Atkinson, Emily, Abdalla, Ahmed, Gavins, Francesca K. H, Boyd, Ashleigh S, Williams, Gareth R, Knowles, Jonathan C, Roberton, Victoria H, Phillips, James B

“…Treatment options for neurodegenerative conditions such as Parkinson's disease have included the delivery of cells which release dopamine or neurotrophic…”
Get full text

Concise Review: Immune Recognition of Induced Pluripotent Stem Cells by Boyd, Ashleigh S., Rodrigues, Neil P., Lui, Kathy O., Fu, Xuemei, Xu, Yang

“…Autologous‐induced pluripotent stem cells (iPSCs) may eventually be used in cell replacement therapies to treat a wide range of diseases and have been touted…”
Get full text

Lack of Immune Response to Differentiated Cells Derived from Syngeneic Induced Pluripotent Stem Cells by Guha, Prajna, Morgan, John W., Mostoslavsky, Gustavo, Rodrigues, Neil P., Boyd, Ashleigh S.

Get full text

Microfluidic devices towards personalized health and wellbeing by Marques, Marco PC, Boyd, Ashleigh S, Polizzi, Karen, Szita, Nicolas

“…To make personalised medicine a reality, there is a significant need for cost‐effective methods that enable the rapid selection of optimal nutrient intake…”
Get full text

Inhibition of GATA2 restrains cell proliferation and enhances apoptosis and chemotherapy mediated apoptosis in human GATA2 overexpressing AML cells by Menendez-Gonzalez, Juan Bautista, Sinnadurai, Samantha, Gibbs, Alex, Thomas, Leigh-anne, Konstantinou, Maria, Garcia-Valverde, Alfonso, Boyer, Magali, Wang, Zhengke, Boyd, Ashleigh S., Blair, Allison, Morgan, Rhys G., Rodrigues, Neil P.

“…GATA2, a zinc finger transcription factor predominantly expressed in hematopoietic cells, acts as an essential regulator of hematopoietic stem cell generation,…”
Get full text

Haploinsufficiency of GATA-2 perturbs adult hematopoietic stem-cell homeostasis by Rodrigues, Neil P., Janzen, Viktor, Forkert, Randolf, Dombkowski, David M., Boyd, Ashleigh S., Orkin, Stuart H., Enver, Tariq, Vyas, Paresh, Scadden, David T.

“…The zinc finger transcription factor GATA-2 plays a fundamental role in generating hematopoietic stem-cells in mammalian development. Less well defined is…”
Get full text

A Role for Regulatory T Cells in Acceptance of ESC‐Derived Tissues Transplanted Across an Major Histocompatibility Complex Barrier by Lui, Kathy O., Boyd, Ashleigh S., Cobbold, Stephen P., Waldmann, Herman, Fairchild, Paul J.

“…We have previously reported that ESC‐derived tissues are subject to some level of immune privilege, which might facilitate induction of immune tolerance…”
Get full text

A Comparison of Protocols Used to Generate Insulin‐Producing Cell Clusters from Mouse Embryonic Stem Cells by Boyd, Ashleigh S., Wu, Douglas C., Higashi, Yasuyuki, Wood, Kathryn J.

“…Embryonic stem cells (ESCs) have the capacity to generate a panoply of tissue types and may therefore provide an alternative source of tissue in regenerative…”
Get full text

Embryonic stem cell transplantation: potential applicability in cell replacement therapy and regenerative medicine by Wu, Douglas C, Boyd, Ashleigh S, Wood, Kathryn J

“…Embryonic stem cells are derived from the inner cell mass of the trophoblast, and have the ability to differentiate into all the tissues of the fetus. As such,…”
Get full text

Approaches for immunological tolerance induction to stem cell-derived cell replacement therapies by Boyd, Ashleigh S, Fairchild, Paul J

“…The shortage of donors for organ transplantation and also to treat degenerative diseases has led to the development of the new field of regenerative medicine…”
Get more information