Search Results - "Boyan, B D"

High surface energy enhances cell response to titanium substrate microstructure by Zhao, G., Schwartz, Z., Wieland, M., Rupp, F., Geis-Gerstorfer, J., Cochran, D. L., Boyan, B. D.

“…Titanium (Ti) is used for implantable devices because of its biocompatible oxide surface layer. TiO2 surfaces that have a complex microtopography increase…”
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Electrical Implications of Corrosion for Osseointegration of Titanium Implants by Gittens, R.A., Olivares-Navarrete, R., Tannenbaum, R., Boyan, B.D., Schwartz, Z.

“…The success rate of titanium implants for dental and orthopedic applications depends on the ability of surrounding bone tissue to integrate with the surface of…”
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Pulsed electromagnetic fields enhance BMP-2 dependent osteoblastic differentiation of human mesenchymal stem cells by Schwartz, Z., Simon, B. J., Duran, M. A., Barabino, G., Chaudhri, R., Boyan, B. D.

“…Mesenchymal stem cells (MSCs) express an osteoblastic phenotype when treated with BMP‐2, and BMP‐2 is used clinically to induce bone formation although high…”
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Influence of topography and hydrophilicity on initial oral biofilm formation on microstructured titanium surfaces in vitro by Almaguer-Flores, A., Olivares-Navarrete, R., Wieland, M., Ximénez-Fyvie, L. A., Schwartz, Z., Boyan, B. D.

“…Objectives: The aim of this study was to analyse the influence of the microtopography and hydrophilicity of titanium (Ti) substrates on initial oral biofilm…”
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Microrough implant surface topographies increase osteogenesis by reducing osteoclast formation and activity by Lossdörfer, S., Schwartz, Z., Wang, L., Lohmann, C. H., Turner, J. D., Wieland, M., Cochran, D. L., Boyan, B. D.

“…Titanium implant surfaces with rough microtopographies exhibit increased pullout strength in vivo suggesting increased bone‐to‐implant contact. This is…”
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Ribozyme knockdown functionally links a 1,25(OH)2D3 membrane binding protein (1,25D3-MARRS) and phosphate uptake in intestinal cells by Nemere, I, Farach-Carson, M C, Rohe, B, Sterling, T M, Norman, A W, Boyan, B D, Safford, S E

“…We used a ribozyme loss-of-function approach to demonstrate that the protein product of a cDNA encoding a multifunctional membrane-associated protein binds the…”
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17β-Estradiol Regulates Rat Growth Plate Chondrocyte Apoptosis Through a Mitochondrial Pathway Not Involving Nitric Oxide or MAPKs by Zhong, M, Carney, D. H, Boyan, B. D, Schwartz, Z

“…Estrogens cause growth plate closure in both males and females, by decreasing proliferation and inducing apoptosis of postproliferative growth plate…”
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24R,25-Dihydroxyvitamin D3, lysophosphatidic acid, and p53: A signaling axis in the inhibition of phosphate-induced chondrocyte apoptosis by Hurst-Kennedy, J., Zhong, M., Gupta, V., Boyan, B.D., Schwartz, Z.

“…Maintenance of the pool of chondrocytes in the resting zone of the growth plate in the presence of the physiological apoptogen inorganic phosphate (Pi) is…”
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Underlying mechanisms at the bone-biomaterial interface by Schwartz, Z, Boyan, B D

“…In order to understand how biomaterials influence bone formation in vivo, it is necessary to examine cellular response to materials in the context of wound…”
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Role of the N-terminal peptide of amelogenin on osteoblastic differentiation of human mesenchymal stem cells by Olivares-Navarrete, R, Vesper, K, Hyzy, S L, Almaguer-Flores, A, Boyan, B D, Schwartz, Z

“…Porcine enamel matrix derivative (pEMD), a complex mixture of proteins and peptides including full-length amelogenin protein, splice variants, and proteolytic…”
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Identification of a Membrane Receptor for 1,25‐Dihydroxyvitamin D3 Which Mediates Rapid Activation of Protein Kinase C by Nemere, I., Schwartz, Z., Pedrozo, H., Sylvia, V. L., Dean, D. D., Boyan, B. D.

“…This paper is the first definitive report demonstrating a unique membrane receptor for 1,25‐dihydroxyvitamin D3(1,25(OH)2D3) which mediates the rapid and…”
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Osteoblasts generate an osteogenic microenvironment when grown on surfaces with rough microtopographies by Boyan, B D, Lossdörfer, S, Wang, L, Zhao, G, Lohmann, C H, Cochran, D L, Schwartz, Z

“…Osteoblasts respond to microarchitectural features of their substrate. On smooth surfaces (tissue culture plastic, tissue culture glass, and titanium), the…”
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Pulsed electromagnetic fields affect phenotype and connexin 43 protein expression in MLO-Y4 osteocyte-like cells and ROS 17/2.8 osteoblast-like cells by Lohmann, C.H., Schwartz, Z., Liu, Y., Li, Z., Simon, B.J., Sylvia, V.L., Dean, D.D., Bonewald, L.F., Donahue, H.J., Boyan, B.D.

“…Osteocytes, the predominant cells in bone, are postulated to be responsible for sensing mechanical and electrical stimuli, transducing signals via gap…”
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Differential effects of bone graft substitutes on regeneration of bone marrow by Schwartz, Z., Doukarsky-Marx, T., Nasatzky, E., Goultschin, J., Ranly, D. M., Greenspan, D. C., Sela, J., Boyan, B. D.

“…Background: This study used a rat tibial marrow ablation model to test the hypothesis that bone remodeling within the medullary canal varies with bone graft…”
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Maturation State Determines the Response of Osteogenic Cells to Surface Roughness and 1,25‐Dihydroxyvitamin D3 by Lohmann, C. H., Bonewald, L. F., Sisk, M. A., Sylvia, V. L., Cochran, D. L., Dean, D. D., Boyan, B. D., Schwartz, Z.

“…In this study we assessed whether osteogenic cells respond in a differential manner to changes in surface roughness depending on their maturation state…”
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Phagocytosis of wear debris by osteoblasts affects differentiation and local factor production in a manner dependent on particle composition by Lohmann, C.H, Schwartz, Z, Köster, G, Jahn, U, Buchhorn, G.H, MacDougall, M.J, Casasola, D, Liu, Y, Sylvia, V.L, Dean, D.D, Boyan, B.D

“…Wear debris is considered to be one of the main factors responsible for aseptic loosening of orthopaedic endoprostheses. Whereas the response of cells in the…”
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1α,25-Dihydroxyvitamin D3 and 24R,25-Dihydroxyvitamin D3 Modulate Growth Plate Chondrocyte Physiology via Protein Kinase C-Dependent Phosphorylation of Extracellular Signal-Regulated Kinase 1/2 Mitogen-Activated Protein Kinase by Schwartz, Z, Ehland, H, Sylvia, V. L, Larsson, D, Hardin, R. R, Bingham, V, Lopez, D, Dean, D. D, Boyan, B. D

“…Membrane-mediated increases in protein kinase C (PKC) activity and PKC-dependent physiological responses of growth plate chondrocytes to vitamin D metabolites…”
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Pulsed electromagnetic fields increase growth factor release by nonunion cells by Guerkov, H H, Lohmann, C H, Liu, Y, Dean, D D, Simon, B J, Heckman, J D, Schwartz, Z, Boyan, B D

“…The mechanisms involved in pulsed electromagnetic field stimulation of nonunions are not known. Animal and cell culture models suggest endochondral…”
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Strategies for Improving Impaired Osseointegration in Compromised Animal Models by Deng, J., Van Duyn, C., Cohen, D. J., Schwartz, Z., Boyan, B. D.

“…Implant osseointegration is reduced in patients with systemic conditions that compromise bone quality, such as osteoporosis, disuse syndrome, and type 2…”
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Estrogen-Dependent Rapid Activation of Protein Kinase C in Estrogen Receptor-Positive MCF-7 Breast Cancer Cells and Estrogen Receptor-Negative HCC38 Cells Is Membrane-Mediated and Inhibited by Tamoxifen by Boyan, B. D, Sylvia, V. L, Frambach, T, Lohmann, C. H, Dietl, J, Dean, D. D, Schwartz, Z

“…We examined protein kinase C (PKC) in the regulation of breast cancer cells by estrogen. Estrogen receptor (ER)- positive (+) MCF-7 and ER-negative (−) HCC38…”
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