Search Results - "Boyaka, PN"

Effective Mucosal Immunity to Anthrax: Neutralizing Antibodies and Th Cell Responses Following Nasal Immunization with Protective Antigen by Boyaka, Prosper N, Tafaro, Angela, Fischer, Romy, Leppla, Stephen H, Fujihashi, Kohtaro, McGhee, Jerry R

“…Mucosal, but not parenteral, immunization induces immune responses in both systemic and secretory immune compartments. Thus, despite the reports that Abs to…”
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The mode of oral bovine lactoferrin administration influences mucosal and systemic immune responses in mice by Sfeir, Rose Mary, Dubarry, Michel, Boyaka, Prosper N, Rautureau, Michèle, Tomé, Daniel

“…Food protein intake interacts with the immune system. In earlier nutritional and immunological studies, nutrients, particularly milk whey proteins, were…”
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Bacillus anthracis Edema Toxin Acts as an Adjuvant for Mucosal Immune Responses to Nasally Administered Vaccine Antigens by Duverger, Alexandra, Jackson, Raymond J, van Ginkel, Frederick W, Fischer, Romy, Tafaro, Angela, Leppla, Stephen H, Fujihashi, Kohtaro, Kiyono, Hiroshi, McGhee, Jerry R, Boyaka, Prosper N

“…Anthrax edema toxin (EdTx) is an AB-type toxin that binds to anthrax toxin receptors on target cells via the binding subunit, protective Ag (PA). Edema factor,…”
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Mechanisms for Induction of Acquired Host Immunity by Neutrophil Peptide Defensins by Lillard, James W., Boyaka, Prosper N., Chertov, Oleg, Oppenheim, Joost J., McGhee, Jerry R.

“…Human neutrophil peptide (HNP) defensins were studied to determine their potential effects on adaptive mucosal immunity. Intranasal delivery of HNPs plus…”
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In situ gastrointestinal protection against anthrax edema toxin by single-chain antibody fragment producing lactobacilli by Andersen, Kasper Krogh, Marcotte, Harold, Álvarez, Beatriz, Boyaka, Prosper N, Hammarström, Lennart

“…Anthrax is caused by the bacterium Bacillus anthracis and is regarded as one of the most prominent bioterrorism threats. Anthrax toxicity is induced by the…”
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MIP-1α and MIP-1β differentially mediate mucosal and systemic adaptive immunity by Lillard, James W., Singh, Udai P., Boyaka, Prosper N., Singh, Shailesh, Taub, Dennis D., McGhee, Jerry R.

“…Macrophage inflammatory protein-1α (MIP-1α) and MIP-1β are distinct but highly homologous CC chemokines produced by a variety of host cells in response to…”
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Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4 by Marinaro, M, Staats, HF, Hiroi, T, Jackson, RJ, Coste, M, Boyaka, PN, Okahashi, N, Yamamoto, M, Kiyono, H, Bluethmann, H

“…Despite pathophysiologic effects including diarrhea, cholera toxin (CT) is a potent mucosal immunogen and adjuvant. We investigated the influence of CT on T…”
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Oral and Nasal Sensitization Promote Distinct Immune Responses and Lung Reactivity in a Mouse Model of Peanut Allergy by Fischer, Romy, McGhee, Jerry R., Vu, Huong Lan, Atkinson, T. Prescott, Jackson, Raymond J., Tomé, Daniel, Boyaka, Prosper N.

“…Despite structural and functional differences between the initial sites of contact with allergens in the gastrointestinal and nasal tracts, few animal models…”
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RANTES Potentiates Antigen-Specific Mucosal Immune Responses by Lillard, James W., Jr, Boyaka, Prosper N, Taub, Dennis D, McGhee, Jerry R

“…RANTES is produced by lymphoid and epithelial cells of the mucosa in response to various external stimuli and is chemotactic for lymphocytes. The role of…”
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Human Nasopharyngeal-Associated Lymphoreticular Tissues : Functional Analysis of Subepithelial and Intraepithelial B and T Cells from Adenoids and Tonsils by Boyaka, Prosper N, Wright, Peter F, Marinaro, Mariarosaria, Kiyono, Hiroshi, Johnson, Joyce E, Gonzales, Ricardo A, Ikizler, Mine R, Werkhaven, Jay A, Jackson, Raymond J, Fujihashi, Kohtaro, Di Fabio, Simonetta, Staats, Herman F, McGhee, Jerry R

“…Subepithelial and intraepithelial lymphocytes of human adenoids and tonsils were characterized and directly compared to determine the potential contribution of…”
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IL-12 Is an Effective Adjuvant for Induction of Mucosal Immunity by Boyaka, Prosper N, Marinaro, Mariarosaria, Jackson, Raymond J, Menon, Satish, Kiyono, Hiroshi, Jirillo, Emilio, McGhee, Jerry R

“…We addressed the effects of two cytokines, IL-6 and IL-12, derived from APCs, for the development of mucosal IgA Ab responses following their nasal delivery…”
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Chimeras of Labile Toxin One and Cholera Toxin Retain Mucosal Adjuvanticity and Direct Th Cell Subsets Via Their B Subunit by Boyaka, Prosper N, Ohmura, Mari, Fujihashi, Kohtaro, Koga, Toshiya, Yamamoto, Masafumi, Kweon, Mi-Na, Takeda, Yoshifumi, Jackson, Raymond J, Kiyono, Hiroshi, Yuki, Yoshikazu, McGhee, Jerry R

“…Native cholera toxin (nCT) and the heat-labile toxin 1 (nLT) of enterotoxigenic Escherichia coli are AB5-type enterotoxins. Both nCT and nLT are effective…”
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Oral but not parenteral interleukin (IL)-12 redirects T helper 2 (Th2)-type responses to an oral vaccine without altering mucosal IgA responses by Marinaro, M, Boyaka, P N, Finkelman, F D, Kiyono, H, Jackson, R J, Jirillo, E, McGhee, J R

“…Our past studies have shown that the mucosal adjuvant cholera toxin (CT) induces T helper type 2 (Th2) responses with systemic IgG1, IgE and mucosal secretory…”
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Peanut-lupine antibody cross-reactivity is not associated to cross-allergenicity in peanut-sensitized mouse strains by Lifrani, Awatif, Dubarry, Michel, Rautureau, Michèle, Aattouri, Najat, Boyaka, Prosper N., Tomé, Daniel

“…Peanut hypersensitivity is one of the most common food allergies and one of the most common causes of death by food anaphylaxis in children and adults…”
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Therapeutic manipulation of the immune system: enhancement of innate and adaptive mucosal immunity by Boyaka, Prosper N, Tafaro, Angela, Fischer, Romy, Fujihashi, Kohtaro, Jirillo, Emilio, McGhee, Jerry R

“…The mucosal immune system has evolved alongside, but separate, from the general systemic immune system. As a major consequence of this dichotomy, only immune…”
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Oral QS-21 Requires Early IL-4 Help for Induction of Mucosal and Systemic Immunity by Boyaka, Prosper N, Marinaro, Mariarosaria, Jackson, Raymond J, van Ginkel, Frederik W, Cormet-Boyaka, Estelle, Kirk, Kevin L, Kensil, Charlotte R, McGhee, Jerry R

“…The highly purified saponin derivative, QS-21, from the Quillaja saponaria Molina tree has been proved to be safe for parenteral administration and represents…”
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Use of Intranasal IL-12 to Target Predominantly Th1 Responses to Nasal and Th2 Responses to Oral Vaccines Given with Cholera Toxin by Marinaro, Mariarosaria, Boyaka, Prosper N, Jackson, Raymond J, Finkelman, Fred D, Kiyono, Hiroshi, Jirillo, Emilio, McGhee, Jerry R

“…We have investigated the effects of IL-12 and cholera toxin (CT) on the immune response to tetanus toxoid (TT) given by intranasal or oral routes. CT inhibited…”
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Syntaxin 1A is expressed in airway epithelial cells, where it modulates CFTR Cl(-) currents by Naren, A P, Di, A, Cormet-Boyaka, E, Boyaka, P N, McGhee, J R, Zhou, W, Akagawa, K, Fujiwara, T, Thome, U, Engelhardt, J F, Nelson, D J, Kirk, K L

“…The CFTR Cl(-) channel controls salt and water transport across epithelial tissues. Previously, we showed that CFTR-mediated Cl(-) currents in the Xenopus…”
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Lymphotactin Acts as an Innate Mucosal Adjuvant by Lillard, James W., Jr, Boyaka, Prosper N, Hedrick, Joseph A, Zlotnik, Albert, McGhee, Jerry R

“…Lymphotactin (Lptn) is a C chemokine produced predominantly by NK and CD8-positive (CD8+) T cells including gammadelta TCR-positive (TCR+) intraepithelial…”
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Cytokines as adjuvants for the induction of mucosal immunity by Boyaka, Prosper N., McGhee, Jerry R.

“…Safe nasal vaccines capable of promoting both mucosal and systemic immunity are needed for effective protection against bacterial and viral pathogens. While…”
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