Search Results - "Boyaci, Hande"
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1
Diverse and unified mechanisms of transcription initiation in bacteria
Published in Nature reviews. Microbiology (01-02-2021)“…Transcription of DNA is a fundamental process in all cellular organisms. The enzyme responsible for transcription, RNA polymerase, is conserved in general…”
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2
Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding
Published in Nature (London) (01-01-2019)“…A key regulated step of transcription is promoter melting by RNA polymerase (RNAP) to form the open promoter complex 1 – 3 . To generate the open complex, the…”
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3
Basis of narrow-spectrum activity of fidaxomicin on Clostridioides difficile
Published in Nature (London) (21-04-2022)“…Fidaxomicin (Fdx) is widely used to treat Clostridioides difficile ( Cdiff ) infections, but the molecular basis of its narrow-spectrum activity in the human…”
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4
Fidaxomicin jams Mycobacterium tuberculosis RNA polymerase motions needed for initiation via RbpA contacts
Published in eLife (26-02-2018)“…Fidaxomicin (Fdx) is an antimicrobial RNA polymerase (RNAP) inhibitor highly effective against RNAP in vitro, but clinical use of Fdx is limited to treating…”
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5
Selective Manipulation of ICT and PET Processes in Styryl-Bodipy Derivatives: Applications in Molecular Logic and Fluorescence Sensing of Metal Ions
Published in Journal of the American Chemical Society (16-06-2010)“…Remarkably versatile chemistry of Bodipy dyes allows the design and straightforward synthesis of multivalent-multitopic derivatives, which, with judicious…”
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6
Structure, Regulation, and Inhibition of the Quorum-Sensing Signal Integrator LuxO
Published in PLoS biology (24-05-2016)“…In a process called quorum sensing, bacteria communicate with chemical signal molecules called autoinducers to control collective behaviors. In pathogenic…”
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7
Engineering A Uranyl-Specific Binding Protein from NikR
Published in Angewandte Chemie (International ed.) (01-01-2009)“…A new pick-up line: The first uranyl-selective DNA-binding protein is designed using the E. coli nickel(II)-responsive protein NikR as the template. The…”
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8
The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase
Published in Proceedings of the National Academy of Sciences - PNAS (01-12-2020)“…Rifampicin (Rif) is a first-line therapeutic used to treat the infectious disease tuberculosis (TB), which is caused by the pathogen Mycobacterium tuberculosis…”
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9
Emissive Nucleosides as Molecular Rotors
Published in Chemphyschem (25-02-2011)“…Sticky fingers: The emission intensity of modified pyrimidines containing an aryl moiety, linked by a single bond to the nucleobase in the 5‐position, show a…”
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10
Transcription initiation in mycobacteria: a biophysical perspective
Published in Transcription (14-03-2020)“…Recent biophysical studies of mycobacterial transcription have shed new light on this fundamental process in a group of bacteria that includes deadly pathogens…”
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11
Engineering A Uranyl‐Specific Binding Protein from NikR
Published in Angewandte Chemie (16-03-2009)“…Ein uranylselektives DNA bindendes Protein wurde ausgehend von dem Nickel(II)‐responsiven Protein NikR aus E. coli als Templat entwickelt. Das resultierende…”
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Journal Article -
12
Structural and functional studies of the regulation and inhibition of LuxO, a AAA+ ATPase
Published 2017“…Quorum sensing is a widespread form of bacterial cell-cell communication that entails the production, release, and detection of small molecules called…”
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Dissertation -
13
Engineering A Uranyl‐Specific Binding Protein from NikR
Published in Angewandte Chemie (16-03-2009)“…Ein uranylselektives DNA bindendes Protein wurde ausgehend von dem Nickel(II)‐responsiven Protein NikR aus E. coli als Templat entwickelt. Das resultierende…”
Get full text
Journal Article