Search Results - "Boxer, P A"

Subtype-Selective N-Methyl-d-Aspartate Receptor Antagonists:  Synthesis and Biological Evaluation of 1-(Heteroarylalkynyl)-4-benzylpiperidines by Wright, Jon L, Gregory, Tracy F, Kesten, Suzanne R, Boxer, Peter A, Serpa, Kevin A, Meltzer, Leonard T, Wise, Lawrence D, Espitia, Stephen A, Konkoy, Christopher S, Whittemore, Edward R, Woodward, Richard M

“…4-[4-(4-Benzylpiperidin-1-yl)but-1-ynyl]phenol (8) and 4-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]phenol (9) are potent NR1a/2B receptor antagonists (IC50 values…”
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Assessment of the role of the glutathione and pentose phosphate pathways in the protection of primary cerebrocortical cultures from oxidative stress by Ben-Yoseph, O, Boxer, P A, Ross, B D

“…Reactive oxygen species have been implicated in neuronal injury associated with various neuropathological disorders. However, little is known regarding the…”
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Functional Differences Between Monocyte Chemotactic Protein-1 Receptor A and Monocyte Chemotactic Protein-1 Receptor B Expressed in a Jurkat T Cell by Sanders, Sheila K, Crean, Sheila M, Boxer, Peter A, Kellner, Debra, LaRosa, Gregory J, Hunt, Stephen W., III

“…The monocyte chemotactic protein-1 (MCP-1) receptor (MCP-1R) is expressed on monocytes, a subpopulation of memory T lymphocytes, and basophils. Two…”
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Suicide and occupation: a review of the literature by Boxer, P A, Burnett, C, Swanson, N

“…Suicide is the eighth leading cause of death in the United States. Suicide rates have been reported to be particularly high in professional, managerial, and…”
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A specific inhibitor of calcium/calmodulin-dependent protein kinase-II provides neuroprotection against NMDA- and hypoxia/hypoglycemia-induced cell death by Hajimohammadreza, I, Probert, AW, Coughenour, LL, Borosky, SA, Marcoux, FW, Boxer, PA, Wang, KK

“…Calcium/calmodulin-dependent protein kinase-II (CamK-II) is a major neuronal protein which plays a significant role in the cellular process of long-term…”
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Psychological Distress and Alcohol Use among fire Fighters by Boxer, Peter A, Wild, Deanna

“…Few studies have investigated Stressors to which fire fighters are subjected and the potential psychological consequences. One hundred and forty-five fire…”
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Mechanisms of neuronal cell injury/death and targets for drug intervention by Boxer, Peter A., Bigge, Christopher F.

“…The loss of neurons is responsible for many acute neurological disorders, as well as many chronic neurodegenerative diseases. Drug discovery research has…”
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4-Hydroxy-1-[2-(4-hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidine:  A Novel, Potent, and Selective NR1/2B NMDA Receptor Antagonist by Zhou, Zhang-Lin, Cai, Sui Xiong, Whittemore, Edward R, Konkoy, Christopher S, Espitia, Stephen A, Tran, Minhtam, Rock, David M, Coughenour, Linda L, Hawkinson, Jon E, Boxer, Peter A, Bigge, Christopher F, Wise, Lawrence D, Weber, Eckard, Woodward, Richard M, Keana, John F. W

“…A structure-based search and screen of our compound library identified N-(2-phenoxyethyl)-4-benzylpiperidine (8) as a novel N-methyl-d-aspartate (NMDA)…”
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Inhibitors of V‐Type ATPases, Bafilomycin A1 and Concanamycin A, Protect Against β‐Amyloid‐Mediated Effects on 3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐Diphenyltetrazolium Bromide (MTT) Reduction by Kane, Michael D., Schwarz, Roy D., Pierre, Linda St, Watson, M. Desiree, Emmerling, Mark R., Boxer, Peter A., Walker, Glenn K.

“…: The functional viability of cells can be evaluated using a number of different assay determinants. One common assay involves exposing cells to…”
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Synthesis of 1,4,7,8,9,10-hexahydro-9-methyl-6-nitropyrido[3,4-f]-quinoxaline-2,3-dione and related quinoxalinediones: characterization of .alpha.-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (and N-methyl-D-aspartate) receptor and anticonvulsant activity by Bigge, Christopher F, Malone, Thomas C, Boxer, Peter A, Nelson, Carrie B, Ortwine, Daniel F, Schelkun, Robert, Retz, Daniel M, Lescosky, Leonard J, Borosky, Susan A

“…Four related series of substituted quinoxalinediones containing angular fused-piperidine rings have been synthesized as…”
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Basic electrophysiological properties of spinal cord motoneurons during old age in the cat by Morales, F R, Boxer, P A, Fung, S J, Chase, M H

“…1. The electrophysiological properties of alpha-motoneurons in old cats (14-15 yr) were compared with those of adult cats (1-3 yr). These properties were…”
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Outpatient treatment for "multiple chemical sensitivities" by Boxer, P A

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Oxidative stress in the central nervous system: monitoring the metabolic response using the pentose phosphate pathway by Ben-Yoseph, O, Boxer, P A, Ross, B D

“…We propose that monitoring the activity of the pentose phosphate pathway (PPP) may provide an opportunity to obtain unique information regarding the metabolic…”
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Subtype-Selective N-Methyl-d-aspartate Receptor Antagonists:  Synthesis and Biological Evaluation of 1-(Arylalkynyl)-4-benzylpiperidines by Wright, Jon L, Gregory, Tracy F, Bigge, Christopher F, Boxer, Peter A, Serpa, Kevin, Meltzer, Leonard T, Wise, Lawrence D, Cai, Sui Xiong, Hawkinson, Jon E, Konkoy, Christopher S, Whittemore, Edward R, Woodward, Richard M, Zhou, Zhang-Lin

“…A search of our compound library for compounds with structural similarity to ifenprodil (5) and haloperidol (7) followed by in vitro screening revealed that…”
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Comparison of phenytoin with noncompetitive N-methyl-D-aspartate antagonists in a model of focal brain ischemia in rat by Boxer, P A, Cordon, J J, Mann, M E, Rodolosi, L C, Vartanian, M G, Rock, D M, Taylor, C P, Marcoux, F W

“…Recent in vitro and in vivo experiments have suggested that excitatory amino acid antagonists, particularly those active at the N-methyl-D-aspartate receptor…”
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Noninvasive assessment of the relative roles of cerebral antioxidant enzymes by quantitation of pentose phosphate pathway activity by BEN-YOSEPH, O, BOXER, P. A, ROSS, B. D

“…Cerebral pentose phosphate pathway (PPP) plays a role in the biosynthesis of macromolecules, antioxidant defense and neurotransmitter metabolism. Studies on…”
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The Cortical Basal ganglia Functional Scale (CBFS): Development and preliminary validation by Lang, Anthony E., Stebbins, Glenn T., Wang, Ping, Jabbari, Edwin, Lamb, Ruth, Morris, Huw, Boxer, Adam L., Boxer (PI), A., Boeve, B., Dickerson, B., Grossman, M., Litvan, I., Ljubenkov, P., Pantelyat, A., Rojas-Martinez, J., Tartaglia, M.-C., Wills, A.-M., Morris (PI), H., Amar, K., Capps, E., Carey, G., Church, A., Critchley, P., Ghosh, B., Houlden, H., Hu, M., Jabbari, Edwin, Kobylecki, C., Massey, L., Molloy, S., Nath, U., Pavese, N., Rowe, J.B.

“…To develop a patient/care-giver reported scale capable of easily and reliably assessing functional disability in 4 repeat tauopathies (4RTs). 4R tauopathies…”
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The voltage-sensitive Ca2+ channel (VSCC) antagonists omega-Aga-IVA and omega-CTX-MVIIC inhibit spontaneous epileptiform discharges in the rat cortical wedge by Robichaud, L J, Wurster, S, Boxer, P A

“…The ability of VSCC antagonists to modulate excitatory amino acid (EAA) release was evaluated by measuring N-methyl-D-aspartate (NMDA) receptor-dependent…”
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Polyamine modulation of excitatory amino acid responses in the rat cortical wedge by Robichaud, L J, Boxer, P A

“…Rat neocortex slices in Mg2+ free buffer show spontaneous discharges which have a constant frequency and are dependent on N-methyl-D-aspartate (NMDA) receptor…”
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Assessment of potential violence in the paranoid worker by Boxer, P A

“…Violence in the workplace is sometimes a manifestation of an untreated psychiatric disorder. Paranoid personality disorder, paranoid schizophrenia, and…”
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