Search Results - "Box, K J"

pH-metric logP 10. Determination of liposomal membrane-water partition coefficients of ionizable drugs by AVDEEF, A, BOX, K. J, COMER, J. E. A, HIBBERT, C, TAM, K. Y

“…To investigate a novel approach for the determination of liposomal membrane-water partition coefficients and lipophilicity profiles of ionizable drugs. The…”
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Multiwavelength spectrophotometric determination of acid dissociation constants of ionizable drugs by Allen, R.I., Box, K.J., Comer, J.E.A., Peake, C., Tam, K.Y.

“…A multiwavelength spectrophotometric approach has been developed to determine acid dissociation constants (p K a values) of sparingly soluble drug compounds…”
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Using measured pKa, LogP and solubility to investigate supersaturation and predict BCS class by Box, K J, Comer, J E A

“…Ionization, lipophilicity and solubility have a profound influence on the transport properties of drug molecules. We will present an overview of why…”
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Characterisation of selected active agents regarding pKa values, solubility concentrations and pH profiles by SiriusT3 by Schönherr, D., Wollatz, U., Haznar-Garbacz, D., Hanke, U., Box, K.J., Taylor, R., Ruiz, R., Beato, S., Becker, D., Weitschies, W.

“…[Display omitted] •pKa values and solubility properties of 34 APIs were determined using SiriusT3.•Experimentally obtained, calculated and published pKa values…”
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Determination of protonation macro- and microconstants and octanol/water partition coefficient of the antiinflammatory drug niflumic acid by Takács-Novák, K, Avdeef, A, Box, K J, Podányi, B, Szász, G

“…The drug niflumic acid is an amphoteric substance with overlapping pKa values. The acid-base chemistry of the molecule has been characterized in terms of…”
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PH-metric log p 11. pKa determination of water-insoluble drugs in organic solvent-water mixtures by AVDEEF, A, BOX, K. J, COMER, J. E. A, GILGES, M, HADLEY, M, HIBBERT, C, PATTERSON, W, TAM, K. Y

“…The apparent acid dissociation constants (p(s)Ka) of two water-insoluble drugs, ibuprofen and quinine, were determined pH-metrically in acetonitrile water,…”
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pH-Induced Precipitation Behavior of Weakly Basic Compounds: Determination of Extent and Duration of Supersaturation Using Potentiometric Titration and Correlation to Solid State Properties by Hsieh, Yi-Ling, Ilevbare, Grace A., Van Eerdenbrugh, Bernard, Box, Karl J., Sanchez-Felix, Manuel Vincente, Taylor, Lynne S.

“…ABSTRACT Purpose To examine the precipitation and supersaturation behavior of ten weak bases in terms of the relationship between pH-concentration-time…”
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pH-metric log P. 6. Effects of sodium, potassium, and N-CH3-D-glucamine on the octanol-water partitioning of prostaglandins E1 and E2 by Avdeef, A, Box, K J, Takács-Novák, K

“…The pH-dependent octanol-water partition behavior of prostaglandins (Pg) E1 and E2 was studied by an automated potentiometric titration method. In 0.15 M KCl…”
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Potentiometric pKa determination of water-insoluble compounds : validation study in methanol/water mixtures by TAKACS-NOVAK, K, BOX, K. J, AVDEEF, A

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Structure-Lipophilicity Relationships of Neutral and Protonated β-Blockers, Part I, Intra- and Intermolecular Effects in Isotropic Solvent Systems by Caron, Giulia, Steyaert, Guillaume, Pagliara, Alessandra, Reymond, Frédéric, Crivori, Patrizia, Gaillard, Patrick, Carrupt, Pierre-Alain, Avdeef, Alex, Comer, John, Box, Karl J., Girault, Hubert H., Testa, Bernard

“…The objectives of this study were to validate new experimental techniques used to measure the log P of protonated drugs, and to investigate the inter‐ and…”
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