Search Results - "Bowman, Karen J"

SIP1 protein protects cells from DNA damage-induced apoptosis and has independent prognostic value in bladder cancer by Sayan, A. Emre, Griffiths, Thomas R, Pal, Raj, Browne, Gareth J, Ruddick, Andrew, Yagci, Tamer, Edwards, Richard, Mayer, Nick J, Qazi, Hasan, Goyal, Sandeep, Fernandez, Serena, Straatman, Kees, Jones, George D.D, Bowman, Karen J, Colquhoun, Alexandra, Mellon, J. Kilian, Kriajevska, Marina, Tulchinsky, Eugene

“…The epithelial-mesenchymal transition (EMT) contributes to cancer metastasis. Two ZEB family members, ZEB1 and ZEB2(SIP1), inhibit transcription of the…”
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Optimization of Class I Histone Deacetylase PROTACs Reveals that HDAC1/2 Degradation is Critical to Induce Apoptosis and Cell Arrest in Cancer Cells by Smalley, Joshua P, Baker, India M, Pytel, Wiktoria A, Lin, Li-Ying, Bowman, Karen J, Schwabe, John W R, Cowley, Shaun M, Hodgkinson, James T

“…Class I histone deacetylase (HDAC) enzymes 1, 2, and 3 organize chromatin as the catalytic subunits within seven distinct multiprotein corepressor complexes…”
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Simplified method for the collection, storage, and comet assay analysis of DNA damage in whole blood by Al-Salmani, Kamla, Abbas, Hussein H.K., Schulpen, Sjors, Karbaschi, Mahsa, Abdalla, Intisar, Bowman, Karen J., So, Kwok K., Evans, Mark D., Jones, George D.D., Godschalk, Roger W., Cooke, Marcus S.

“…Single-cell gel electrophoresis (comet assay) is one of the most common methods used to measure oxidatively damaged DNA in peripheral blood mononuclear cells…”
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Comet assay measures of DNA damage are predictive of bladder cancer cell treatment sensitivity in vitro and outcome in vivo by Bowman, Karen J., Al‐Moneef, Manar M., Sherwood, Benedict T., Colquhoun, Alexandra J., Goddard, Jonathan C., Griffiths, T.R. Leyshon, Payne, David, Singh, Sadmeet, Butterworth, Paul C., Khan, Masood A., Summerton, Duncan J., Steward, William P., McKelvey‐Martin, Valerie J., McKeown, Stephanie R., Kockelbergh, Roger C., Mellon, J. Kilian, Symonds, R. Paul, Jones, George D.D.

“…Bladder cancer patients suffer significant treatment failure, including high rates of recurrence and poor outcomes for advanced disease. If mechanisms to…”
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Introducing a true internal standard for the Comet assay to minimize intra- and inter-experiment variability in measures of DNA damage and repair by Zainol, Murizal, Stoute, Julia, Almeida, Gabriela M, Rapp, Alexander, Bowman, Karen J, Jones, George D.D

“…The Comet assay (CA) is a sensitive/simple measure of genotoxicity. However, many features of CA contribute variability. To minimize these, we have introduced…”
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Pediatric brain tumor cancer stem cells: cell cycle dynamics, DNA repair, and etoposide extrusion by Hussein, Deema, Punjaruk, Wiyada, Storer, Lisa C.D., Shaw, Lucy, Ottoman, Ramadan, Peet, Andrew, Miller, Suzanne, Bandopadhyay, Gagori, Heath, Rachel, Kumari, Rajendra, Bowman, Karen J., Braker, Paul, Rahman, Ruman, Jones, George D.D., Watson, Susan, Lowe, James, Kerr, Ian D., Grundy, Richard G., Coyle, Beth

“…Reliable model systems are needed to elucidate the role cancer stem cells (CSCs) play in pediatric brain tumor drug resistance. The majority of studies to date…”
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Comet assay measures of DNA damage as biomarkers of irinotecan response in colorectal cancer in vitro and in vivo by Wood, Joanna P., Smith, Andrew J. O., Bowman, Karen J., Thomas, Anne L., Jones, George D. D.

“…The use of irinotecan to treat metastatic colorectal cancer (CRC) is limited by unpredictable response and variable toxicity; however, no reliable clinical…”
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DNA strand breaks and hypoxia response inhibition mediate the radiosensitisation effect of nitric oxide donors on prostate cancer under varying oxygen conditions by Stewart, Grant D., Nanda, Jyoti, Katz, Elad, Bowman, Karen J., Christie, Jill G., Brown, D.J. Gordon, McLaren, Duncan B., Riddick, Antony C.P., Ross, James A., Jones, George D.D., Habib, Fouad K.

“…Prostate cancer cells can exist in a hypoxic microenvironment, causing radioresistance. Nitric oxide (NO) is a radiosensitiser of mammalian cells. NO-NSAIDs…”
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DNA damage in earthworms from highly contaminated soils: Assessing resistance to arsenic toxicity by use of the Comet assay by Button, Mark, Jenkin, Gawen R.T., Bowman, Karen J., Harrington, Chris F., Brewer, Tim S., Jones, George D.D., Watts, Michael J.

“…Earthworms native to the former mine site of Devon Great Consols (DGC), UK reside in soils highly contaminated with arsenic (As). These earthworms are…”
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Protection of Cells in Physiological Oxygen Tensions against DNA Damage-induced Apoptosis by Carrera, Samantha, de Verdier, Petra J., Khan, Zahid, Zhao, Bo, Mahale, Alka, Bowman, Karen J., Zainol, Muri, Jones, George D.D., Lee, Sam W., Aaronson, Stuart A., Macip, Salvador

“…Oxygen availability has important effects on cell physiology. Although hyperoxic and hypoxic stresses have been well characterized, little is known about…”
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Resistance-Modifying Agents. 11. Pyrimido[5,4-d]pyrimidine Modulators of Antitumor Drug Activity. Synthesis and Structure−Activity Relationships for Nucleoside Transport Inhibition and Binding to α1-Acid Glycoprotein by Curtin, Nicola J, Barlow, Hannah C, Bowman, Karen J, Calvert, A. Hilary, Davison, Richard, Golding, Bernard T, Huang, Bing, Loughlin, Peter J, Newell, David R, Smith, Peter G, Griffin, Roger J

“…The cardiovascular and antithrombotic agent dipyridamole (DP) has potential therapeutic utility as a modulator of the activity of antimetabolite antitumor…”
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Phosphate Alkylation in Different DNA Substrates:  The Role of Local DNA Sequence and Electrophile Character in Determining the Nonrandom Nature of Phosphotriester Adduct Formation by Le Pla, Rachel C, Bowman, Karen J, Farmer, Peter B, Jones, George D. D

“…DNA phosphate oxygens are sites for alkylation leading to DNA phosphotriester adduct (PTE) formation. Previously, we have reported that the manifestation of…”
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Improving and predicting radiosensitivity in muscle invasive bladder cancer by Colquhoun, Alexandra J, Jones, George D D, Moneef, Manar Al, Bowman, Karen J, Kockelbergh, Roger C, Symonds, R Paul, Steward, Will P, Mellon, J Kilian

“…Muscle invasive bladder cancer is a common urological malignancy with a relatively poor prognosis and 5-year survival rates ranging from 20% to 90%. We review…”
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Further Development of 32P-Postlabeling for the Detection of Alkylphosphotriesters:  Evidence for the Long-Term Nonrandom Persistence of Ethyl-Phosphotriester Adducts in Vivo by Le Pla, Rachel C, Guichard, Yves, Bowman, Karen J, Gaskell, Margaret, Farmer, Peter B, Jones, George D. D

“…DNA phosphate oxygens are sites for alkylation leading to phosphotriester adducts (PTEs). PTEs are reported to be both abundant and persistent and so may serve…”
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Evaluation of phosphodiesterase I-based protocols for the detection of multiply damaged sites in DNA: the detection of abasic, oxidative and alkylative tandem damage in DNA oligonucleotides by Bowman, Karen J., Pla, Rachel Le, Guichard, Yves, Farmer, Peter B., Jones, George D. D.

“…It has been proposed that DNA multiply damaged sites (MDS), where more than one moiety in a local region (∼1 helical turn, 10 bp) of the DNA is damaged, are…”
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Abstract 3444: Identification of a miRNAs signature of radioresistance in a prostate cancer model by McDermott, Niamh, Meunier, Armelle, Hernandez, Christopher, Bowman, Karen J., Jones, George D., Marignol, Laure

“…Abstract Introduction Radiotherapy (RT) has a prominent role when used as a single modality or in combination with androgen deprivation therapy (ADT) in the…”
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DNA damage of macrophages at an air-tissue interface induced by metal nanoparticles by Grigg, Jonathan, Tellabati, Ananth, Rhead, Stephen, Almeida, Gabriela M., Higgins, Jennifer A., Bowman, Karen J., Jones, George D., Howes, Paul B.

“…Abstract An air-tissue interface model was used to assess nanoparticulate-induced DNA damage to airway macrophages. Human Mono Mac 6 cells and rat alveolar…”
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Further Development of 32 P-Postlabeling for the Detection of Alkylphosphotriesters:  Evidence for the Long-Term Nonrandom Persistence of Ethyl-Phosphotriester Adducts in Vivo by Le Pla, Rachel C., Guichard, Yves, Bowman, Karen J., Gaskell, Margaret, Farmer, Peter B., Jones, George D. D.

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Resistance-modifying agents. 11.(1) Pyrimido[5,4-d]pyrimidine modulators of antitumor drug activity. Synthesis and structure-activity relationships for nucleoside transport inhibition and binding to alpha1-acid glycoprotein by Curtin, Nicola J, Barlow, Hannah C, Bowman, Karen J, Calvert, A Hilary, Davison, Richard, Golding, Bernard T, Huang, Bing, Loughlin, Peter J, Newell, David R, Smith, Peter G, Griffin, Roger J

“…The cardiovascular and antithrombotic agent dipyridamole (DP) has potential therapeutic utility as a modulator of the activity of antimetabolite antitumor…”
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Resistance-Modifying Agents. 11. Pyrimido[5,4- d ]pyrimidine Modulators of Antitumor Drug Activity. Synthesis and Structure−Activity Relationships for Nucleoside Transport Inhibition and Binding to α 1 -Acid Glycoprotein by Curtin, Nicola J., Barlow, Hannah C., Bowman, Karen J., Calvert, A. Hilary, Davison, Richard, Golding, Bernard T., Huang, Bing, Loughlin, Peter J., Newell, David R., Smith, Peter G., Griffin, Roger J.

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