Search Results - "Bowman, Cindy M"
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Structural Constraints of Vaccine-Induced Tier-2 Autologous HIV Neutralizing Antibodies Targeting the Receptor-Binding Site
Published in Cell reports (Cambridge) (05-01-2016)“…Antibodies that neutralize autologous transmitted/founder (TF) HIV occur in most HIV-infected individuals and can evolve to neutralization breadth. Autologous…”
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Amino Acid Changes in the HIV-1 gp41 Membrane Proximal Region Control Virus Neutralization Sensitivity
Published in EBioMedicine (01-10-2016)“…Most HIV-1 vaccines elicit neutralizing antibodies that are active against highly sensitive (tier-1) viruses or rare cases of vaccine-matched…”
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Immune checkpoint modulation enhances HIV-1 antibody induction
Published in Nature communications (19-02-2020)“…Eliciting protective titers of HIV-1 broadly neutralizing antibodies (bnAbs) is a goal of HIV-1 vaccine development, but current vaccine strategies have yet to…”
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HIV DNA-Adenovirus Multiclade Envelope Vaccine Induces gp41 Antibody Immunodominance in Rhesus Macaques
Published in Journal of virology (01-11-2017)“…Dominant antibody responses in vaccinees who received the HIV-1 multiclade (A, B, and C) envelope (Env) DNA/recombinant adenovirus virus type 5 (rAd5) vaccine…”
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Tissue memory B cell repertoire analysis after ALVAC/AIDSVAX B/E gp120 immunization of rhesus macaques
Published in JCI insight (08-12-2016)“…The ALVAC prime/ALVAC + AIDSVAX B/E boost RV144 vaccine trial induced an estimated 31% efficacy in a low-risk cohort where HIV‑1 exposures were likely at…”
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HIV-1 Envelope Mimicry of Host Enzyme Kynureninase Does Not Disrupt Tryptophan Metabolism
Published in The Journal of immunology (1950) (15-12-2016)“…The HIV-1 envelope protein (Env) has evolved to subvert the host immune system, hindering viral control by the host. The tryptophan metabolic enzyme…”
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Immunodominance of Antibody Recognition of the HIV Envelope V2 Region in Ig-Humanized Mice
Published in The Journal of immunology (1950) (01-02-2017)“…In the RV144 gp120 HIV vaccine trial, decreased transmission risk was correlated with Abs that reacted with a linear epitope at a lysine residue at position…”
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Immunodominance of antibody recognition of the HIV envelope second variable region in immunoglobulin humanized mice
Published in The Journal of immunology (1950) (23-12-2016)“…In the RV144 gp120 HIV vaccine trial, decreased transmission risk was correlated with antibodies that reacted with a linear epitope at a lysine at position 169…”
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