Search Results - "Bowman, Christine"

The Presence of a Transporter-Induced Protein Binding Shift: A New Explanation for Protein-Facilitated Uptake and Improvement for In Vitro-In Vivo Extrapolation by Bowman, Christine M, Okochi, Hideaki, Benet, Leslie Z

“…Accurately predicting hepatic clearance is an integral part of the drug-development process, and yet current in vitro to in vivo (IVIVE) extrapolation methods…”
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An Exceptionally Potent Inhibitor of Human CD73 by Bowman, Christine E, da Silva, Rafael G, Pham, Amber, Young, Stephen W

“…We recently reported the initiation of a Phase I clinical trial with AB680, a potent human CD73 inhibitor, being developed for the treatment of solid tumors…”
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Improving the Translation of Organic Anion Transporting Polypeptide Substrates using HEK293 Cell Data in the Presence and Absence of Human Plasma via Physiologically Based Pharmacokinetic Modeling by Bowman, Christine M, Chen, Buyun, Cheong, Jonathan, Liu, Liling, Chen, Yuan, Mao, Jialin

“…Accurately predicting the pharmacokinetics of compounds that are transporter substrates has been notoriously challenging using traditional in vitro systems and…”
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Pre-exposure prophylaxis to prevent the acquisition of HIV-1 infection (PROUD): effectiveness results from the pilot phase of a pragmatic open-label randomised trial by McCormack, Sheena, Prof, Dunn, David T, Prof, Desai, Monica, MPH, Dolling, David I, MSc, Gafos, Mitzy, PhD, Gilson, Richard, MD, Sullivan, Ann K, MD, Clarke, Amanda, BM, Reeves, Iain, MBChB, Schembri, Gabriel, MBBS, Mackie, Nicola, MD, Bowman, Christine, BM, Lacey, Charles J, Prof, Apea, Vanessa, MPH, Brady, Michael, BM, Fox, Julie, MD, Taylor, Stephen, PhD, Antonucci, Simone, PhD, Khoo, Saye H, Prof, Rooney, James, MD, Nardone, Anthony, PhD, Fisher, Martin, Prof, McOwan, Alan, MBBS, Phillips, Andrew N, Prof, Johnson, Anne M, Prof, Gazzard, Brian, Prof, Gill, Owen N, Prof

“…Summary Background Randomised placebo-controlled trials have shown that daily oral pre-exposure prophylaxis (PrEP) with tenofovir–emtricitabine reduces the…”
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Interlaboratory Variability in Human Hepatocyte Intrinsic Clearance Values and Trends with Physicochemical Properties by Bowman, Christine M., Benet, Leslie Z.

“…Purpose To examine the interlaboratory variability in CL int values generated with human hepatocytes and determine trends in variability and clearance…”
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In Vitro-In Vivo Inaccuracy: The CYP3A4 Anomaly by Bowman, Christine M, Benet, Leslie Z

“…When predicting hepatic clearance using in vitro to in vivo extrapolation (IVIVE), microsomes or hepatocytes are commonly used. Here, we examine intrinsic…”
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Hepatic Clearance Predictions from In Vitro-In Vivo Extrapolation and the Biopharmaceutics Drug Disposition Classification System by Bowman, Christine M, Benet, Leslie Z

“…Predicting in vivo pharmacokinetic parameters such as clearance from in vitro data is a crucial part of the drug-development process. There is a commonly cited…”
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The Extended Clearance Concept Following Oral and Intravenous Dosing: Theory and Critical Analyses by Benet, Leslie Z., Bowman, Christine M., Liu, Shufang, Sodhi, Jasleen K.

“…Purpose To derive the theoretical basis for the extended clearance model of organ elimination following both oral and IV dosing, and critically analyze the…”
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How Transporters Have Changed Basic Pharmacokinetic Understanding by Benet, Leslie Z., Bowman, Christine M., Sodhi, Jasleen K.

“…The emergence and continued evolution of the transporter field has caused re-evaluation and refinement of the original principles surrounding drug disposition…”
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Changes in Organic Anion Transporting Polypeptide Uptake in HEK293 Overexpressing Cells in the Presence and Absence of Human Plasma by Bowman, Christine M, Chen, Eugene, Chen, Liuxi, Chen, Yi-Chen, Liang, Xiaorong, Wright, Matthew, Chen, Yuan, Mao, Jialin

“…Generating accurate in vitro data is crucial for in vitro to in vivo extrapolation and pharmacokinetic predictions. The use of human embryonic kidney (HEK) 293…”
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General Base–General Acid Catalysis in Human Histone Deacetylase 8 by Gantt, Sister M. Lucy, Decroos, Christophe, Lee, Matthew S, Gullett, Laura E, Bowman, Christine M, Christianson, David W, Fierke, Carol A

“…Histone deacetylases (HDACs) regulate cellular processes such as differentiation and apoptosis and are targeted by anticancer therapeutics in development and…”
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Examination of Physiologically‐Based Pharmacokinetic Models of Rosuvastatin by Bowman, Christine M., Ma, Fang, Mao, Jialin, Chen, Yuan

“…Physiologically‐based pharmacokinetic (PBPK) modeling is increasingly used to predict drug disposition and drug–drug interactions (DDIs). However, accurately…”
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Characterization of AB598, a CD39 Enzymatic Inhibitory Antibody for the Treatment of Solid Tumors by Anderson, Amy E, Parashar, Kaustubh, Jin, Ke, Clor, Julie, Stagnaro, Carlo E, Vani, Urvi, Singh, Jaskirat, Chen, Ada, Guan, Yihong, Talukdar, Priyanka, Sathishkumar, Pavithra, Juat, Damie J, Singh, Hema, Kushwaha, Ritu, Zhao, Xiaoning, Kaplan, Angelo, Seitz, Lisa, Walters, Matthew J, Fernandez-Salas, Ester, Walker, Nigel P C, Bowman, Christine E

“…AB598 is a CD39 inhibitory antibody being pursued for the treatment of solid tumors in combination with chemotherapy and immunotherapy. CD39 metabolizes…”
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Continuing Delay in the Diagnosis of Slipped Capital Femoral Epiphysis by Schur, Mathew D., BA, Andras, Lindsay M., MD, Broom, Alexander M., MD, Barrett, Kody K., MD, Bowman, Christine A., BA, Luther, Herman, BA, Goldstein, Rachel Y., MD, MPH, Fletcher, Nicholas D., MD, Millis, Michael B., MD, Runner, Robert, MD, Skaggs, David L., MD, MMM

“…Objective To evaluate whether the time from symptom onset to diagnosis of slipped capital femoral epiphysis (SCFE) has improved over a recent decade compared…”
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Biochemical and Structural Characterization of HDAC8 Mutants Associated with Cornelia de Lange Syndrome Spectrum Disorders by Decroos, Christophe, Christianson, Nicolas H, Gullett, Laura E, Bowman, Christine M, Christianson, Karen E, Deardorff, Matthew A, Christianson, David W

“…Cornelia de Lange Syndrome (CdLS) spectrum disorders are characterized by multiple organ system congenital anomalies that result from mutations in genes…”
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Extremity Pressure in Splints Wrapped With an Elastic Bandage Versus Bias Cut Stockinette: An Experimental Model by Schoenfeldt, Theodore L., Bowman, Christine A., MacConnell, Ashley E., Fishman, Felicity G.

“…Background: Many variables affect the pressure caused by splinting or casting. The purpose of this study was to compare pressure underlying a splint wrapped…”
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Understanding drug–drug interaction and pharmacogenomic changes in pharmacokinetics for metabolized drugs by Benet, Leslie Z., Bowman, Christine M., Koleske, Megan L., Rinaldi, Capria L., Sodhi, Jasleen K.

“…Here we characterize and summarize the pharmacokinetic changes for metabolized drugs when drug–drug interactions and pharmacogenomic variance are observed…”
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How does specialist nursing contribute to HIV service delivery across England? by Piercy, Hilary, Bell, Gill, Hughes, Charlie, Naylor, Simone, Bowman, Christine A

“…This study aimed to examine what specialist nursing contributes to HIV service delivery across England and how it could be optimised. A three part multi-method…”
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Discovery of potent dihydro-oxazinoquinolinone inhibitors of GuaB for the treatment of tuberculosis by Zhou, Yuebiao, Aliagas, Ignacio, Wang, Shumei, Li, Chun Sing, Liu, Zhiguo, Bowman, Christine M., Burdick, Daniel J., Clark, Kevin R., Dening, Tahnee J., Flygare, John, Ganti, Anjani, Girgis, Hany S., Hanan, Emily J., Harris, Seth F., Hu, Chloe, Kapadia, Sharookh B., Koehler, Michael F.T., Lai, Tommy, Liang, Jun, Liu, Xingrong, Ma, Fang, Mao, Jialin, Nicolai, Jeremy, Sims, Jessica, Unhayaker, Savita, Wai, John, Wang, Xiaojing, Wu, Ping, Xu, Yiming, Yen, Chun-Wan, Zhang, Renwei, Elfert, Torben F., Tan, Man-Wah, Kofoed, Eric M., Crawford, Terry D.

“…[Display omitted] •GuaB is a promising target for the treatment of tuberculosis.•Structure-based drug design led to the identification of…”
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Understanding CYP3A4 and P‐gp mediated drug–drug interactions through PBPK modeling – Case example of pralsetinib by Bowman, Christine, Dolton, Michael, Ma, Fang, Cheeti, Sravanthi, Kuruvilla, Denison, Sane, Rucha, Kassir, Nastya, Chen, Yuan

“…Pralsetinib, a potent and selective inhibitor of oncogenic RET fusion and RET mutant proteins, is a substrate of the drug metabolizing enzyme CYP3A4 and a…”
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