Search Results - "Bowles, D"

Biomaterials for Intervertebral Disc Regeneration and Repair by Bowles, Robert D., Ph.D, Setton, Lori A., Ph.D

“…Abstract The intervertebral disc contributes to motion, weight bearing, and flexibility of the spine, but is susceptible to damage and morphological changes…”
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Lentiviral CRISPR Epigenome Editing of Inflammatory Receptors as a Gene Therapy Strategy for Disc Degeneration by Farhang, Niloofar, Ginley-Hidinger, Matt, Berrett, Kristofer C, Gertz, Jason, Lawrence, Brandon, Bowles, Robby D

“…Degenerative disc disease (DDD) is a primary contributor to low-back pain, a leading cause of disability. Progression of DDD is aided by inflammatory cytokines…”
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A zebrafish model of X-linked adrenoleukodystrophy recapitulates key disease features and demonstrates a developmental requirement for abcd1 in oligodendrocyte patterning and myelination by Strachan, Lauren R, Stevenson, Tamara J, Freshner, Briana, Keefe, Matthew D, Miranda Bowles, D, Bonkowsky, Joshua L

“…X-linked adrenoleukodystrophy (ALD) is a devastating inherited neurodegenerative disease caused by defects in the ABCD1 gene and affecting peripheral and…”
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Tissue-engineered intervertebral discs produce new matrix, maintain disc height, and restore biomechanical function to the rodent spine by Bowles, Robby D, Gebhard, Harry H, Härtl, Roger, Bonassar, Lawrence J

“…Lower back and neck pain are leading physical conditions for which patients see their doctors in the United States. The organ commonly implicated in this…”
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Targeted therapy for advanced salivary gland carcinoma based on molecular profiling: results from MyPathway, a phase IIa multiple basket study by Kurzrock, R., Bowles, D.W., Kang, H., Meric-Bernstam, F., Hainsworth, J., Spigel, D.R., Bose, R., Burris, H., Sweeney, C.J., Beattie, M.S., Blotner, S., Schulze, K., Cuchelkar, V., Swanton, C.

“…Systemic therapy options for salivary cancers are limited. MyPathway (NCT02091141), a phase IIa study, evaluates targeted therapies in non-indicated tumor…”
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Safety and efficacy of pralsetinib in RET fusion–positive non-small-cell lung cancer including as first-line therapy: update from the ARROW trial by Griesinger, F., Curigliano, G., Thomas, M., Subbiah, V., Baik, C.S., Tan, D.S.W., Lee, D.H., Misch, D., Garralda, E., Kim, D.-W., van der Wekken, A.J., Gainor, J.F., Paz-Ares, L., Liu, S.V., Kalemkerian, G.P., Houvras, Y., Bowles, D.W., Mansfield, A.S., Lin, J.J., Smoljanovic, V., Rahman, A., Kong, S., Zalutskaya, A., Louie-Gao, M., Boral, A.L., Mazières, J.

“…RET fusions are present in 1%-2% of non-small-cell lung cancer (NSCLC). Pralsetinib, a highly potent, oral, central nervous system-penetrant, selective RET…”
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Calculation of standardised unit costs from a societal perspective for health economic evaluation by Bock, J-O, Brettschneider, C, Seidl, H, Bowles, D, Holle, R, Greiner, W, König, H H

“…Due to demographic aging, economic evaluation of health care technologies for the elderly becomes more important. A standardised questionnaire to measure the…”
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Vanishing white matter disease expression of truncated EIF2B5 activates induced stress response by Keefe, Matthew D, Soderholm, Haille E, Shih, Hung-Yu, Stevenson, Tamara J, Glaittli, Kathryn A, Bowles, D Miranda, Scholl, Erika, Colby, Samuel, Merchant, Samer, Hsu, Edward W, Bonkowsky, Joshua L

“…Vanishing white matter disease (VWM) is a severe leukodystrophy of the central nervous system caused by mutations in subunits of the eukaryotic initiation…”
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XactMice: humanizing mouse bone marrow enables microenvironment reconstitution in a patient-derived xenograft model of head and neck cancer by Morton, J J, Bird, G, Keysar, S B, Astling, D P, Lyons, T R, Anderson, R T, Glogowska, M J, Estes, P, Eagles, J R, Le, P N, Gan, G, McGettigan, B, Fernandez, P, Padilla-Just, N, Varella-Garcia, M, Song, J I, Bowles, D W, Schedin, P, Tan, A-C, Roop, D R, Wang, X-J, Refaeli, Y, Jimeno, A

“…The limitations of cancer cell lines have led to the development of direct patient-derived xenograft models. However, the interplay between the implanted human…”
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Effects of High Dose Bolus Cholecalciferol on Free Vitamin D Metabolites, Bone Turnover Markers and Physical Function by Bowles, Simon D, Jacques, Richard, Hill, Thomas R, Eastell, Richard, Walsh, Jennifer S

“…High dose bolus cholecalciferol supplementation has been associated with falls and fracture, and this does not appear to be due to hypercalcaemia. The primary…”
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Comprehensive genomic profiles of metastatic and relapsed salivary gland carcinomas are associated with tumor type and reveal new routes to targeted therapies by Ross, J.S., Gay, L.M., Wang, K., Vergilio, J.A., Suh, J., Ramkissoon, S., Somerset, H., Johnson, J.M., Russell, J., Ali, S., Schrock, A.B., Fabrizio, D., Frampton, G., Miller, V., Stephens, P.J., Elvin, J.A., Bowles, D.W.

“…Relapsed/metastatic salivary gland carcinomas (SGCs) have a wide diversity of histologic subtypes associated with variable clinical aggressiveness and response…”
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Comprehensive genomic profiling of salivary mucoepidermoid carcinomas reveals frequent BAP1, PIK3CA, and other actionable genomic alterations by Wang, K, McDermott, J D, Schrock, A B, Elvin, J A, Gay, L, Karam, S D, Raben, D, Somerset, H, Ali, S M, Ross, J S, Bowles, D W

“…We sought to identify genomic alterations (GAs) in salivary mucoepidermoid carcinomas. DNA was extracted from 48 mucoepidermoid carcinomas. Comprehensive…”
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A multicenter phase 1 study of PX-866 in combination with docetaxel in patients with advanced solid tumours by Bowles, D W, Ma, W W, Senzer, N, Brahmer, J R, Adjei, A A, Davies, M, Lazar, A J, Vo, A, Peterson, S, Walker, L, Hausman, D, Rudin, C M, Jimeno, A

“…Background: This phase I, dose-finding study determined the safety, maximum tolerated dose (MTD)/recommended phase 2 dose (RP2D), pharmacokinetics, and…”
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An automated system for rapid cellular extraction from live zebrafish embryos and larvae: Development and application to genotyping by Lambert, Christopher J, Freshner, Briana C, Chung, Arlen, Stevenson, Tamara J, Bowles, D Miranda, Samuel, Raheel, Gale, Bruce K, Bonkowsky, Joshua L

“…Zebrafish are a valuable model organism in biomedical research. Their rapid development, ability to model human diseases, utility for testing genetic variants…”
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FIMA--questionnaire for health-related resource use in an elderly population: development and pilot study by Seidl, H, Bowles, D, Bock, J-O, Brettschneider, C, Greiner, W, König, H-H, Holle, R

“…Due to demographic trends towards an ageing population resource use of health care will increase. By collecting health-related costs via questionnaires, the…”
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Mechanism of beneficial effects of physical activity on atherosclerosis and coronary heart disease by Bowles, D K, Laughlin, M H

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Sialidase and Sialyltransferase Inhibitors: Targeting Pathogenicity and Disease by Bowles, William H. D., Gloster, Tracey M.

“…Sialidases (SAs) and sialyltransferases (STs), the enzymes responsible for removing and adding sialic acid to other glycans, play essential roles in viruses,…”
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Profiling of Kidney Injury Biomarkers in Patients Receiving Cisplatin: Time‐dependent Changes in the Absence of Clinical Nephrotoxicity by George, B, Wen, X, Mercke, N, Gomez, M, O'Bryant, C, Bowles, DW, Hu, Y, Hogan, SL, Joy, MS, Aleksunes, LM

“…The success of cisplatin‐containing regimens to treat solid tumors is limited, in part, by nephrotoxicity. In rodents, several urinary proteins have emerged…”
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Self-assembly of aligned tissue-engineered annulus fibrosus and intervertebral disc composite via collagen gel contraction by Bowles, Robby D, Williams, Rebecca M, Zipfel, Warren R, Bonassar, Lawrence J

“…Many cartilaginous tissues such as intervertebral disc (IVD) display a heterogeneous collagen microstructure that results in mechanical anisotropy. These…”
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Circulating total 25(OH)D and calculated free 25(OH)D in professional academy footballers at a northerly latitude in the UK by Bowles, Simon D, Basu, Subhashis, Ranchordas, Mayur K, Simper, Trevor, Lynn, Anthony

“…There is limited data on the vitamin D status of UK-based professional academy footballers. Therefore, the objective of this study was to report total 25(OH)D,…”
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