Search Results - "Bowler, Timothy G"

Mitochondrial Inhibition Augments the Efficacy of Imatinib by Resetting the Metabolic Phenotype of Gastrointestinal Stromal Tumor by Vitiello, Gerardo A, Medina, Benjamin D, Zeng, Shan, Bowler, Timothy G, Zhang, Jennifer Q, Loo, Jennifer K, Param, Nesteene J, Liu, Mengyuan, Moral, Alec J, Zhao, Julia N, Rossi, Ferdinand, Antonescu, Cristina R, Balachandran, Vinod P, Cross, Justin R, DeMatteo, Ronald P

“…Imatinib dramatically reduces gastrointestinal stromal tumor (GIST) F-FDG uptake, providing an early indicator of treatment response. Despite decreased glucose…”
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Differential immune profiles distinguish the mutational subtypes of gastrointestinal stromal tumor by Vitiello, Gerardo A, Bowler, Timothy G, Liu, Mengyuan, Medina, Benjamin D, Zhang, Jennifer Q, Param, Nesteene J, Loo, Jennifer K, Goldfeder, Rachel L, Chibon, Frederic, Rossi, Ferdinand, Zeng, Shan, DeMatteo, Ronald P

“…Gastrointestinal stromal tumor (GIST) is the most common human sarcoma, frequently characterized by an oncogenic mutation in the KIT or platelet-derived growth…”
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Clinical sequencing of soft tissue and bone sarcomas delineates diverse genomic landscapes and potential therapeutic targets by Nacev, Benjamin A., Sanchez-Vega, Francisco, Smith, Shaleigh A., Antonescu, Cristina R., Rosenbaum, Evan, Shi, Hongyu, Tang, Cerise, Socci, Nicholas D., Rana, Satshil, Gularte-Mérida, Rodrigo, Zehir, Ahmet, Gounder, Mrinal M., Bowler, Timothy G., Luthra, Anisha, Jadeja, Bhumika, Okada, Azusa, Strong, Jonathan A., Stoller, Jake, Chan, Jason E., Chi, Ping, D’Angelo, Sandra P., Dickson, Mark A., Kelly, Ciara M., Keohan, Mary Louise, Movva, Sujana, Thornton, Katherine, Meyers, Paul A., Wexler, Leonard H., Slotkin, Emily K., Glade Bender, Julia L., Shukla, Neerav N., Hensley, Martee L., Healey, John H., La Quaglia, Michael P., Alektiar, Kaled M., Crago, Aimee M., Yoon, Sam S., Untch, Brian R., Chiang, Sarah, Agaram, Narasimhan P., Hameed, Meera R., Berger, Michael F., Solit, David B., Schultz, Nikolaus, Ladanyi, Marc, Singer, Samuel, Tap, William D.

“…The genetic, biologic, and clinical heterogeneity of sarcomas poses a challenge for the identification of therapeutic targets, clinical research, and advancing…”
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Oncogenic KIT Modulates Type I IFN-Mediated Antitumor Immunity in GIST by Liu, Mengyuan, Etherington, Mark S, Hanna, Andrew, Medina, Benjamin D, Vitiello, Gerardo A, Bowler, Timothy G, Param, Nesteene J, Levin, Lillian, Rossi, Ferdinand, DeMatteo, Ronald P

“…Type I IFNs are implicated in tumor immunogenicity and response to systemic therapy, but their interaction with oncogene signaling is not well understood…”
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ETV4 collaborates with Wnt/β-catenin signaling to alter cell cycle activity and promote tumor aggressiveness in gastrointestinal stromal tumor by Zeng, Shan, Seifert, Adrian M, Zhang, Jennifer Q, Kim, Teresa S, Bowler, Timothy G, Cavnar, Michael J, Medina, Benjamin D, Vitiello, Gerardo A, Rossi, Ferdinand, Loo, Jennifer K, Param, Nesteene J, DeMatteo, Ronald P

“…Gastrointestinal stromal tumor (GIST) is the most common sarcoma, often resulting from a or platelet-derived growth factor receptor alpha ( ) mutation. The…”
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Misidentification of MLL3 and other mutations in cancer due to highly homologous genomic regions by Bowler, Timothy G., Pradhan, Kith, Kong, Yu, Bartenstein, Matthias, Morrone, Kerry A., Sridharan, Ashwin, Kessel, Rachel M., Shastri, Aditi, Giricz, Orsi, Bhagat, Tushar D., Gordon-Mitchell, Shanisha, Rohanizadegan, Mersedeh, Hooda, Lauren, Datt, Ishan, Przychodzen, Bartlomiej P., Parmar, Simrit, Maqbool, Shahina, Maciejewski, Jaroslaw P., Steidl, Ulrich, Greally, John M., Verma, Amit

“…The MLL3 gene has been shown to be recurrently mutated in many malignancies including in families with acute myeloid leukemia. We demonstrate that many MLL3…”
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Downstream targets of fushi tarazu by Bowler, Timothy G

“…fushi tarazu (ftz) is expressed in a segmentally repeating seven stripe pattern during Drosophila melanogaster embryogenesis, and is required for the…”
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