Search Results - "Bowler, Andrew"
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Hemostatic effect of a monoclonal antibody mAb 2021 blocking the interaction between FXa and TFPI in a rabbit hemophilia model
Published in Blood (14-06-2012)“…Hemophilia is treated by IV replacement therapy with Factor VIII (FVIII) or Factor IX (FIX), either on demand to resolve bleeding, or as prophylaxis. Improved…”
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Synthesis and in Vitro Characterization of 1-(4-Aminofurazan-3-yl)-5-dialkylaminomethyl-1H-[1,2,3]triazole-4-carboxylic Acid Derivatives. A New Class of Selective GSK-3 Inhibitors
Published in Journal of medicinal chemistry (17-07-2003)“…A novel class of GSK-3 inhibitors with favorable water solubility was identified in a HTS screen. SAR studies identified bioisosteric structural moieties in…”
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Preclinical exploration of combined glucagon inhibition and liver-preferential insulin for treatment of diabetes using in vitro assays and rat and mouse models
Published in Diabetologia (01-02-2023)“…Aims/hypothesis Normalisation of blood glucose in individuals with diabetes is recommended to reduce development of diabetic complications. However, risk of…”
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Stereoselective synthesis of non-proteinogenic amino acids
Published in Tetrahedron (28-07-1997)“…The lactam enolate of the protected pyroglutamic acid ester ( 1) has been shown to react with activated imines to yield optically pure derivatives of…”
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Journal Article -
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Families of pairs of graphs with a large number of common cards
Published in Journal of graph theory (01-02-2010)“…The vertex‐deleted subgraph G−v, obtained from the graph G by deleting the vertex v and all edges incident to v, is called a card of G. The deck of G is the…”
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Recognizing connectedness from vertex-deleted subgraphs
Published in Journal of graph theory (01-08-2011)“…Let G be a graph of order n. The vertex‐deleted subgraph G − v, obtained from G by deleting the vertex v and all edges incident to v, is called a card of G…”
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Freedom to operate: a new approach for 2021?
Published in Managing Intellectual Property (03-03-2021)“…Andrew Bowler and Matt Raynor of Bristows examine the challenges faced by the traditional freedom to operate model and why companies are changing their…”
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Trade Publication Article -
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On the fixed points of an automorphism of a symmetric design
Published in Discrete mathematics (06-03-1995)“…It is shown for a non-identity automorphism α of a symmetric 2-( v, k, λ) design fixing f points that f⩽ 1 4 (ν+3κ−6) if|α|⩾3 , f⩽ 1 3 (ν+2κ−4) if|α|⩾2 where…”
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Orthomorphisms of dihedral groups
Published in Discrete mathematics (15-04-1997)“…For n 1, 5 (mod 6) it is shown that the dihedral group of order 4 n admits a pair of orthogonal orthomorphisms…”
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The synthesis of new adenosine A3 selective ligands containing bioisosteric isoxazoles
Published in Bioorganic & medicinal chemistry letters (07-07-1998)“…The synthesis and purinergic receptor binding of novel adenosine A3 ligands is described. Many selective A3 receptor agonists e.g…”
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Journal Article -
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The synthesis of new adenosine A 3 selective ligands containing bioisosteric isoxazoles
Published in Bioorganic & medicinal chemistry letters (1998)“…The synthesis and purinergic receptor binding of novel adenosine A 3 ligands is described. Many selective A 3 receptor agonists e.g…”
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Journal Article -
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On directed designs with block size five
Published in Journal of geometry (01-03-2000)Get full text
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Adenosine A1 and A3 selective N-alkoxypurines as novel cytokine modulators and neuroprotectants
Published in Drug development research (01-11-1998)“…The synthesis, purinergic receptor binding, and biological activity of a series of novel N‐alkoxyadenosine A3 ligands is described. Several reference adenosine…”
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Journal Article Conference Proceeding -
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Adenosine A1 and A3 selectiveN-alkoxypurines as novel cytokine modulators and neuroprotectants
Published in Drug development research (01-11-1998)Get full text
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DESIGNS, GRAPHS, CODES AND THEIR LINKS: (London Mathematical Society Student Texts 22)
Published in Bulletin of the London Mathematical Society (01-09-1992)“…By P. J. Cameron and J. H. van Lint: 240 pp., £35.00, LMS Members' price £12.95, ISBN 0 521 41325 7 (Cambridge University Press, 1991)…”
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Book Review Journal Article -
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The proof is out there
Published in New scientist (1971) (12-10-2002)“…"Philosophy of Mathematics: An introduction to the world of proofs and pictures" by James Robert Brown; "Conversations with a Mathematician: Math, art, science…”
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Magazine Article -
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A beautiful subject
Published in New scientist (1971) (16-03-2002)“…"Mathematical Vistas" by Peter Hilton, Derek Holton and Jean Pedersen; "The Essential John Nash" edited by Harold Kuhn and Sylvia Nasar; and "The Algorithmic…”
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Magazine Article -
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Sum of its parts
Published in New scientist (1971) (06-10-2001)“…The book "Mathematics Unlimited: 2001 and beyond" edited by Bjorn Engquist and Wilfried Schmid is reviewed…”
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Magazine Article