Search Results - "Bowie, Andrew"

Detection of Viral Infections by Innate Immunity by Carty, Michael, Guy, Coralie, Bowie, Andrew G.

“…[Display omitted] Pattern recognition receptors (PRRs) and inflammasomes are a key part of the anti-viral innate immune system as they detect conserved viral…”
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Immune Sensing of DNA by Paludan, Søren R., Bowie, Andrew G.

“…Although it has been appreciated for some years that cytosolic DNA is immune stimulatory, it is only in the past five years that the molecular basis of DNA…”
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Innate immune recognition of DNA: A recent history by Dempsey, Alan, Bowie, Andrew G

“…Abstract Innate immune DNA sensing underpins many physiological and pathological responses to DNA, including anti-viral immunity to DNA viruses. Although it…”
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Innate immune detection of microbial nucleic acids by Gürtler, Claudia, Bowie, Andrew G

“…Highlights • Endosomal TLRs have new functions in sensing RNA. • Mechanisms are known for how RIG-I and MDA5 discriminate between host and viral RNA. •…”
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Viral evasion and subversion of pattern-recognition receptor signalling by Bowie, Andrew G, Unterholzner, Leonie

“…Key Points Viruses are detected by different classes of pattern-recognition receptors (PRRs), including Toll-like receptors (TLRs), RIG-I-like receptors (RLRs)…”
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The history of Toll-like receptors — redefining innate immunity by O'Neill, Luke A. J., Golenbock, Douglas, Bowie, Andrew G.

“…The past 15 years have seen a breakthrough in the field of innate immunity. In this Timeline article, the authors discuss the early events that led to the…”
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The interleukin-1 receptor-associated kinases: Critical regulators of innate immune signalling by Flannery, Sinead, Bowie, Andrew G.

“…The interleukin receptor-associated kinase (IRAK) family are involved in regulating Toll-like receptor (TLR) and interleukin-1 (IL-1) signalling pathways. TLRs…”
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Recent insights into innate immune nucleic acid sensing during viral infection by Guy, Coralie, Bowie, Andrew G

“…Recent advances in our understanding of nucleic acid pattern-recognition receptor (PRR) sensing of viruses have revealed a previously unappreciated level of…”
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Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor by Jin, Tengchuan, Perry, Andrew, Jiang, Jiansheng, Smith, Patrick, Curry, James A., Unterholzner, Leonie, Jiang, Zhaozhao, Horvath, Gabor, Rathinam, Vijay A., Johnstone, Ricky W., Hornung, Veit, Latz, Eicke, Bowie, Andrew G., Fitzgerald, Katherine A., Xiao, T. Sam

“…Recognition of DNA by the innate immune system is central to antiviral and antibacterial defenses, as well as an important contributor to autoimmune diseases…”
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Regulation of type I and type III interferon induction in response to pathogen sensing by Gewaid, Hossam, Bowie, Andrew G

“…Type I and III interferons (IFN-I and IFN-III) have a central role in the early antimicrobial response against invading pathogens. Induction of IFN-Is and…”
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The integral role of iron in ocean biogeochemistry by Tagliabue, Alessandro, Bowie, Andrew R., Boyd, Philip W., Buck, Kristen N., Johnson, Kenneth S., Saito, Mak A.

“…The micronutrient iron is now recognized to be important in regulating the magnitude and dynamics of ocean primary productivity, making it an integral…”
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SARM: From immune regulator to cell executioner by Carty, Michael, Bowie, Andrew G.

“…[Display omitted] SARM is the fifth and most conserved member of the Toll/Il-1 Receptor (TIR) adaptor family. However, unlike the other TIR adaptors, MyD88,…”
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The STING in the tail for cytosolic DNA-dependent activation of IRF3 by Bowie, Andrew

“…Cytosolic pattern recognition receptors (PRRs) sense intracellular nucleic acids from pathogens such as bacteria and viruses, which leads to the induction of…”
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The biogeochemical role of baleen whales and krill in Southern Ocean nutrient cycling by Ratnarajah, Lavenia, Bowie, Andrew R, Lannuzel, Delphine, Meiners, Klaus M, Nicol, Stephen

“…The availability of micronutrients is a key factor that affects primary productivity in High Nutrient Low Chlorophyll (HNLC) regions of the Southern Ocean…”
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Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage by Dunphy, Gillian, Flannery, Sinéad M., Almine, Jessica F., Connolly, Dympna J., Paulus, Christina, Jønsson, Kasper L., Jakobsen, Martin R., Nevels, Michael M., Bowie, Andrew G., Unterholzner, Leonie

“…DNA damage can be sensed as a danger-associated molecular pattern by the innate immune system. Here we find that keratinocytes and other human cells mount an…”
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The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons by Carroll, Elizabeth. C., Jin, Lei, Mori, Andres, Muñoz-Wolf, Natalia, Oleszycka, Ewa, Moran, Hannah B.T., Mansouri, Samira, McEntee, Craig P., Lambe, Eimear, Agger, Else Marie, Andersen, Peter, Cunningham, Colm, Hertzog, Paul, Fitzgerald, Katherine A., Bowie, Andrew G., Lavelle, Ed C.

“…The cationic polysaccharide chitosan is an attractive candidate adjuvant capable of driving potent cell-mediated immunity, but the mechanism by which it acts…”
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Evaluating the role of Toll-like receptors in diseases of the central nervous system by Carty, Michael, Bowie, Andrew G.

“…A key part of the innate immune system is a network of pattern recognition receptors (PRRs) and their associated intracellular signalling pathways. Toll-like…”
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Harnessing poxviral know-how for anti-cytokine therapies by Bowie, Andrew G.

“…Poxviruses have evolved efficient proteins that bind mammalian cytokines and chemokines to suppress host immunity. Here Pontejo et al. examine in detail how…”
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Cytosolic DNA sensors regulating type I interferon induction by Keating, Sinead E, Baran, Marcin, Bowie, Andrew G

“…Type I interferon (IFN) induction is a crucial anti-pathogen response mediated by innate immune stimulation. Although it has been appreciated for some time…”
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Widespread phytoplankton blooms triggered by 2019–2020 Australian wildfires by Tang, Weiyi, Llort, Joan, Weis, Jakob, Perron, Morgane M. G., Basart, Sara, Li, Zuchuan, Sathyendranath, Shubha, Jackson, Thomas, Sanz Rodriguez, Estrella, Proemse, Bernadette C., Bowie, Andrew R., Schallenberg, Christina, Strutton, Peter G., Matear, Richard, Cassar, Nicolas

“…Droughts and climate-change-driven warming are leading to more frequent and intense wildfires 1 – 3 , arguably contributing to the severe 2019–2020 Australian…”
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