Search Results - "Bowersox, S Scott"

Effects of intrathecal administration of ziconotide, a selective neuronal N-type calcium channel blocker, on mechanical allodynia and heat hyperalgesia in a rat model of postoperative pain by Wang, Y X, Pettus, M, Gao, D, Phillips, C, Scott Bowersox, S

“…Ziconotide (SNX-111), a selective blocker of neuronal N-type voltage-sensitive calcium channels, is antinociceptive when it is administered intrathecally. It…”
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Use of Intrathecal SNX-111, a Novel, N-Type, Voltage-Sensitive, Calcium Channel Blocker, in the Management of Intractable Brachial Plexus Avulsion Pain by Brose, William G, Gutlove, David P, Luther, Robert R, Bowersox, S Scott, McGuire, Dawn

“…OBJECTIVE:The objective was to assess the analgesic, antihyperesthesic, and antiallodynic properties of SNX-111 in neuropathic pain. DESIGN:We describe a…”
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Antithrombotic Activity of the Novel Oral Anticoagulant, Tecarfarin [Sodium 3-[4-((1,1,1,3,3,3-hexafluoro-2-methylpropan-2-yloxy) carbonyl) benzyl]-2-oxo-2H-chromen-4-olate] in Animal Models by Bowersox, S. Scott, Canafax, Daniel, Druzgala, Pascal, Milner, Peter, Weitz, Jeffrey I

“…Abstract The antithrombotic activity of tecarfarin, a novel orally active vitamin K epoxide reductase inhibitor, was assessed in canine and rabbit thrombosis…”
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Interactions of intrathecally administered ziconotide, a selective blocker of neuronal N-type voltage-sensitive calcium channels, with morphine on nociception in rats by Wang, Y X, Gao, D, Pettus, M, Phillips, C, Bowersox, S S

“…Ziconotide is a selective, potent and reversible blocker of neuronal N-type voltage-sensitive calcium channels (VSCCs). Morphine is an agonist of mu-opioid…”
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Antinociceptive properties of fenfluramine, a serotonin reuptake inhibitor, in a rat model of neuropathy by Wang, Y X, Bowersox, S S, Pettus, M, Gao, D

“…Fenfluramine is an indirect agonist of 5-hydroxytryptamine (5-HT) receptors that acts by evoking 5-HT release and blocking 5-HT reuptake in neuronal cells. The…”
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Selective blockade of N-type voltage-sensitive calcium channels protects against brain injury after transient focal cerebral ischemia in rats by Scott Bowersox, S., Singh, Tejinder, Luther, Robert R.

“…The neuroprotective efficacy of the selective N-type voltage-sensitive calcium channel blocker, SNX-111, was evaluated in spontaneously hypertensive rats…”
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(S)-4-Methyl-2-(methylamino)pentanoic Acid [4,4-Bis(4-fluorophenyl)butyl]amide Hydrochloride, a Novel Calcium Channel Antagonist, Is Efficacious in Several Animal Models of Pain by Song, Yuntao, Bowersox, S. Scott, Connor, David T, Dooley, David J, Lotarski, Susan M, Malone, Thomas, Miljanich, George, Millerman, Elizabeth, Rafferty, Michael F, Rock, David, Roth, Bruce D, Schmidt, Joann, Stoehr, Sally, Szoke, Balazs G, Taylor, Charles, Vartanian, Mark, Wang, Yong-Xiang

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Preliminary study of the behavioral effects of LBS-neuron implantation on seizure susceptibility following middle cerebral artery occlusion in the rat by Willing, Alison E., Saporta, Samuel, Lixian, Jiang, Milliken, Melissa, Poulos, Steve, Bowersox, Scott S., Sanberg, Paul R.

“…Neural transplantation is a promising treatment strategy that can restore the motor, sensory and cognitive functions in the rat middle cerebral artery…”
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Metabolism and Pharmacokinetics of Naronapride (ATI-7505), a Serotonin 5-HT4 Receptor Agonist for Gastrointestinal Motility Disorders by BOWERSOX, S. Scott, LIGHTNING, Luke K, RAO, Satish, PALME, Monica, ELLIS, Dave, COLEMAN, Renee, DAVIES, Adrian M, KUMARASWAMY, Padmapriya, DRUZGALA, Pascal

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Metabolism and Pharmacokinetics of Naronapride (ATI-7505), a Serotonin 5-HT 4 Receptor Agonist for Gastrointestinal Motility Disorders by Bowersox, S. Scott, Lightning, Luke K., Rao, Satish, Palme, Monica, Ellis, Dave, Coleman, Renee, Davies, Adrian M., Kumaraswamy, Padmapriya, Druzgala, Pascal

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Evidence for multiple [3H]prazosin binding sites in canine brain membranes by Mignot, E, Bowersox, S S, Maddaluno, J, Dement, W, Ciaranello, R

“…Two classes of alpha 1 adrenoceptors were identified in canine brain and liver using conventional radioligand binding methods. Scatchard plots of specific…”
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Muscarinic cholinergic receptors and the canine model of narcolepsy by Kilduff, T S, Bowersox, S S, Kaitin, K I, Baker, T L, Ciaranello, R D, Dement, W C

“…The role of the muscarinic cholinergic receptor in narcolepsy was examined using radioligand binding to various brain regions of normal and genetically…”
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Brain dopamine receptor levels elevated in canine narcolepsy by Bowersox, S S, Kilduff, T S, Faull, K F, Zeller-DeAmicis, L, Dement, W C, Ciaranello, R D

“…Concentrations of dopamine D2 receptors in discrete brain areas differed significantly between dogs with the genetically transmitted form of narcolepsy, and…”
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Pharmacotherapeutic potential of omega-conotoxin MVIIA (SNX-111), an N-type neuronal calcium channel blocker found in the venom of Conus magus by Bowersox, S.Scott, Luther, Robert

“…The venoms of piscivorous marine snails of the genus, Conus, are rich sources of bioactive compounds that interact with a wide variety of molecular targets in…”
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Selective N-type neuronal voltage-sensitive calcium channel blocker, SNX-111, produces spinal antinociception in rat models of acute, persistent and neuropathic pain by Bowersox, S S, Gadbois, T, Singh, T, Pettus, M, Wang, Y X, Luther, R R

“…Male Sprague-Dawley rats were used to evaluate the antinociceptive properties of the selective N-type voltage-sensitive calcium channel (VSCC) blocker,…”
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Biogenic amine concentrations in the brains of normal and narcoleptic canines: current status by Faull, K F, Zeller-DeAmicis, L C, Radde, L, Bowersox, S S, Baker, T L, Kilduff, T S, Dement, W C

“…Neuropharmacological data suggest involvement of the biogenic amines in narcolepsy. In previous work, the authors compared monoamine metabolite concentrations…”
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Brain benzodiazepine receptor characteristics in canine narcolepsy by Bowersox, S S, Kilduff, T S, Kaitin, K I, Dement, W C, Ciaranello, R D

“…A regional analysis of brain benzodiazepine (BDZ) receptors was conducted in narcoleptic and normal dogs to determine whether these sites are altered in…”
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Metabolism and pharmacokinetics of naronapride (ATI-7505), a serotonin 5-HT(4) receptor agonist for gastrointestinal motility disorders by Bowersox, S Scott, Lightning, Luke K, Rao, Satish, Palme, Monica, Ellis, Dave, Coleman, Renee, Davies, Adrian M, Kumaraswamy, Padmapriya, Druzgala, Pascal

“…The absorption and disposition of the serotonin 5-HT(4) receptor agonist, naronapride…”
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Rapid eye movement sleep and its relationship to feeding behavior in the adult cat by Bowersox, S S, Baker, T L, Dement, W C

“…The aim of this study was to corroborate a previous report that, in cats kept on a 12:12-hr light-dark schedule, there is a highly significant negative…”
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Synthesis of a Series of 4-Benzyloxyaniline Analogues as Neuronal N-Type Calcium Channel Blockers with Improved Anticonvulsant and Analgesic Properties by Hu, Lain-Yen, Ryder, Todd R, Rafferty, Michael F, Feng, M. Rose, Lotarski, Susan M, Rock, David M, Sinz, Michael, Stoehr, Sally J, Taylor, Charles P, Weber, Mark L, Bowersox, S. Scott, Miljanich, George P, Millerman, Elizabeth, Wang, Yong-Xiang, Szoke, Balazs G

“…In this article, the rationale for the design, synthesis, and biological evaluation of a series of N-type voltage-sensitive calcium channel (VSCC) blockers is…”
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