Search Results - "Bowersox, S S"

Selective N-type neuronal voltage-sensitive calcium channel blocker, SNX-111, produces spinal antinociception in rat models of acute, persistent and neuropathic pain by Bowersox, S S, Gadbois, T, Singh, T, Pettus, M, Wang, Y X, Luther, R R

“…Male Sprague-Dawley rats were used to evaluate the antinociceptive properties of the selective N-type voltage-sensitive calcium channel (VSCC) blocker,…”
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Interactions of intrathecally administered ziconotide, a selective blocker of neuronal N-type voltage-sensitive calcium channels, with morphine on nociception in rats by Wang, Y X, Gao, D, Pettus, M, Phillips, C, Bowersox, S S

“…Ziconotide is a selective, potent and reversible blocker of neuronal N-type voltage-sensitive calcium channels (VSCCs). Morphine is an agonist of mu-opioid…”
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Effects of intrathecal administration of ziconotide, a selective neuronal N-type calcium channel blocker, on mechanical allodynia and heat hyperalgesia in a rat model of postoperative pain by Wang, Y X, Pettus, M, Gao, D, Phillips, C, Scott Bowersox, S

“…Ziconotide (SNX-111), a selective blocker of neuronal N-type voltage-sensitive calcium channels, is antinociceptive when it is administered intrathecally. It…”
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Use of Intrathecal SNX-111, a Novel, N-Type, Voltage-Sensitive, Calcium Channel Blocker, in the Management of Intractable Brachial Plexus Avulsion Pain by Brose, William G, Gutlove, David P, Luther, Robert R, Bowersox, S Scott, McGuire, Dawn

“…OBJECTIVE:The objective was to assess the analgesic, antihyperesthesic, and antiallodynic properties of SNX-111 in neuropathic pain. DESIGN:We describe a…”
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Antithrombotic Activity of the Novel Oral Anticoagulant, Tecarfarin [Sodium 3-[4-((1,1,1,3,3,3-hexafluoro-2-methylpropan-2-yloxy) carbonyl) benzyl]-2-oxo-2H-chromen-4-olate] in Animal Models by Bowersox, S. Scott, Canafax, Daniel, Druzgala, Pascal, Milner, Peter, Weitz, Jeffrey I

“…Abstract The antithrombotic activity of tecarfarin, a novel orally active vitamin K epoxide reductase inhibitor, was assessed in canine and rabbit thrombosis…”
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Pharmacotherapeutic potential of omega-conotoxin MVIIA (SNX-111), an N-type neuronal calcium channel blocker found in the venom of Conus magus by Bowersox, S.Scott, Luther, Robert

“…The venoms of piscivorous marine snails of the genus, Conus, are rich sources of bioactive compounds that interact with a wide variety of molecular targets in…”
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Effect of tecarfarin, a novel vitamin K epoxide reductase inhibitor, on coagulation in beagle dogs by Choppin, A, Irwin, I, Lach, L, McDonald, MG, Rettie, AE, Shao, L, Becker, C, Palme, MP, Paliard, X, Bowersox, S, Dennis, DM, Druzgala, P

“…Background and purpose:  Tecarfarin (ATI‐5923) is a novel vitamin K epoxide reductase inhibitor that is metabolized by esterase (mainly human carboxylesterase…”
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Antinociceptive properties of fenfluramine, a serotonin reuptake inhibitor, in a rat model of neuropathy by Wang, Y X, Bowersox, S S, Pettus, M, Gao, D

“…Fenfluramine is an indirect agonist of 5-hydroxytryptamine (5-HT) receptors that acts by evoking 5-HT release and blocking 5-HT reuptake in neuronal cells. The…”
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A Selective N-Type Calcium Channel Antagonist Protects Against Neuronal Loss After Global Cerebral Ischemia by Valentino, K., Newcomb, R., Gadbois, T., Singh, T., Bowersox, S., Bitner, S., Justice, A., Yamashiro, D., Hoffman, B. B., Ciaranello, R., Miljanich, G., Ramachandran, J.

“…Calcium influx is believed to play a critical role in the cascade of biochemical events leading to neuronal cell death in a variety of pathological settings,…”
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Selective blockade of N-type voltage-sensitive calcium channels protects against brain injury after transient focal cerebral ischemia in rats by Scott Bowersox, S., Singh, Tejinder, Luther, Robert R.

“…The neuroprotective efficacy of the selective N-type voltage-sensitive calcium channel blocker, SNX-111, was evaluated in spontaneously hypertensive rats…”
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Differential blockade of voltage-sensitive calcium channels at the mouse neuromuscular junction by novel omega-conopeptides and omega-agatoxin-IVA by Bowersox, S S, Miljanich, G P, Sugiura, Y, Li, C, Nadasdi, L, Hoffman, B B, Ramachandran, J, Ko, C P

“…This investigation assessed the ability of a variety of calcium channel blocking peptides to block synaptic transmission in the isolated mouse phrenic…”
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The neuroprotective effects of intrathecal administration of the selective N-type calcium channel blocker ziconotide in a rat model of spinal ischemia by Burns, Lindsay H., Jin, Zhen, Bowersox, S.Scott

“…Purpose: Spinal cord ischemia and resulting paraplegia represent a major complication associated with surgical repair of the thoracoabdominal aorta. Although…”
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Synthesis of a Series of 4-Benzyloxyaniline Analogues as Neuronal N-Type Calcium Channel Blockers with Improved Anticonvulsant and Analgesic Properties by Hu, Lain-Yen, Ryder, Todd R, Rafferty, Michael F, Feng, M. Rose, Lotarski, Susan M, Rock, David M, Sinz, Michael, Stoehr, Sally J, Taylor, Charles P, Weber, Mark L, Bowersox, S. Scott, Miljanich, George P, Millerman, Elizabeth, Wang, Yong-Xiang, Szoke, Balazs G

“…In this article, the rationale for the design, synthesis, and biological evaluation of a series of N-type voltage-sensitive calcium channel (VSCC) blockers is…”
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(S)-4-Methyl-2-(methylamino)pentanoic Acid [4,4-Bis(4-fluorophenyl)butyl]amide Hydrochloride, a Novel Calcium Channel Antagonist, Is Efficacious in Several Animal Models of Pain by Song, Yuntao, Bowersox, S. Scott, Connor, David T, Dooley, David J, Lotarski, Susan M, Malone, Thomas, Miljanich, George, Millerman, Elizabeth, Rafferty, Michael F, Rock, David, Roth, Bruce D, Schmidt, Joann, Stoehr, Sally, Szoke, Balazs G, Taylor, Charles, Vartanian, Mark, Wang, Yong-Xiang

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Treatment with a combined cystopexy-colopexy for dysuria and rectal prolapse after bilateral perineal herniorrhaphy in a dog by Gilley, Robert S, Caywood, Dennis D, Lulich, Jody P, Bowersox, Thomas S

“…A 9-year-old castrated male Yorkshire Terrier was evaluated for dysuria and rectal prolapse 2 weeks after bilateral perineal herniorrhaphy. Dysuria was…”
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Peripheral versus central potencies of N-type voltage-sensitive calcium channel blockers by Wang, Y X, Bezprozvannaya, S, Bowersox, S S, Nadasdi, L, Miljanich, G, Mezo, G, Silva, D, Tarczy-Hornoch, K, Luther, R R

“…The ability of a series of synthetic analogues of omega-conopeptides MVIIA (SNX-111) and TVIA (SNX-185) to prevent electrically-evoked norepinephrine release…”
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Sympatholysis After Neuron-Specific, N-Type, Voltage-Sensitive Calcium Channel Blockade: First Demonstration of N-Channel Function in Humans by McGuire, Dawn, Bowersox, Scott, Fellmann, Jere D, Luther, Robert R

“…SNX-111 is the first neuronal N-type, voltagesensitive calcium channel (VSCC) blocker to enter clinical drug development. Areas of potential therapeutic…”
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Optimum Nitrogen Fertilization of Cool-Season Grasses in the Northeast USA by Hall, M.H, Beegle, D.B, Bowersox, R.S, Stout, R.C

“…Many studies have looked at the economically optimum N application rate (cost of N vs. increased yield) for cool-season forage grasses, but few of these…”
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Preliminary study of the behavioral effects of LBS-neuron implantation on seizure susceptibility following middle cerebral artery occlusion in the rat by Willing, Alison E., Saporta, Samuel, Lixian, Jiang, Milliken, Melissa, Poulos, Steve, Bowersox, Scott S., Sanberg, Paul R.

“…Neural transplantation is a promising treatment strategy that can restore the motor, sensory and cognitive functions in the rat middle cerebral artery…”
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Role of central alpha-1 adrenoceptors in canine narcolepsy by MIGNOT, E, GUILLEMINAULT, C, BOWERSOX, S, RAPPAPORT, A, DEMENT, W. C

“…The role of central alpha-1 adrenergic receptors in cataplexy was investigated in genetically narcoleptic Doberman pinschers. Treatment of narcoleptic dogs…”
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