Search Results - "Bower, John F"

Selective Carbon-Carbon Bond Cleavage of Cyclopropylamine Derivatives by Sokolova, Olga O, Bower, John F

“…This review summarizes synthetic developments reported from 1987 to 2019 that exploit C-C single bond cleavage of cyclopropylamine-based systems. The synthetic…”
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Electrophilic Aminating Agents in Total Synthesis by O'Neil, Lauren G., Bower, John F.

“…Classical amination methods involve the reaction of a nitrogen nucleophile with an electrophilic carbon center; however, in recent years, umpoled strategies…”
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Modular Access to Azepines by Directed Carbonylative C–C Bond Activation of Aminocyclopropanes by Wang, Gang-Wei, Bower, John F

“…A modular Rh-catalyzed entry to azepines is outlined. Under a CO atmosphere, protecting group directed C–C bond activation of aminocyclo­propanes provides…”
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Transition Metal Free C–N Bond Forming Dearomatizations and Aryl C–H Aminations by in Situ Release of a Hydroxylamine-Based Aminating Agent by Farndon, Joshua J, Ma, Xiaofeng, Bower, John F

“…We outline a simple protocol that accesses directly unprotected secondary amines by intramolecular C–N bond forming dearomatization or aryl C–H amination. The…”
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Branch-Selective and Enantioselective Iridium-Catalyzed Alkene Hydroarylation via Anilide-Directed C–H Oxidative Addition by Grélaud, Simon, Cooper, Phillippa, Feron, Lyman J, Bower, John F

“…Tertiary benzylic stereocenters are accessed in high enantioselectivity by Ir-catalyzed branch selective addition of anilide ortho-C–H bonds across styrenes…”
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Highly Efficient Narasaka-Heck Cyclizations Mediated by P(3,5-(CF3)2C6H3)3: Facile Access to N-Heterobicyclic Scaffolds by Faulkner, Adele, Bower, John F.

“…N‐heterobicyclic scaffolds: Highly efficient palladium‐catalyzed cyclizations of oxime esters with cyclic alkenes were used as a general entry to…”
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Recent developments in the use of aza-Heck cyclizations for the synthesis of chiral N-heterocycles by Race, Nicholas J, Hazelden, Ian R, Faulkner, Adele, Bower, John F

“…Aza-Heck cyclizations are an emerging method for the construction of chiral N-heterocyclic systems. In these processes, an activated N-O bond replaces the C-X…”
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Branch Selective Murai-type Alkene Hydroarylation Reactions by E M Crisenza, Giacomo, F Bower, John

“…There is significant interest in the development of C–C bond-forming methodologies that directly access challenging benzylic stereocenters. Predominantly,…”
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Oxidative 1,2-Difunctionalization of Ethylene via Gold-Catalyzed Oxyarylation by Harper, Matthew J, Emmett, Edward J, Bower, John F, Russell, Christopher A

“…Under the conditions of oxidative gold catalysis, exposure of ethylene to aryl silanes and alcohols generates products of 1,2-oxyarylation. This provides a…”
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Enantioselective Aza-Heck Cyclizations of N‑(Tosyloxy)carbamates: Synthesis of Pyrrolidines and Piperidines by Ma, Xiaofeng, Hazelden, Ian R, Langer, Thomas, Munday, Rachel H, Bower, John F

“…Pd­(0)-systems modified with SPINOL-derived phosphoramidate ligands promote highly enantioselective aza-Heck cyclizations of alkenyl N-(tosyloxy)­carbamates…”
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A Simple and Broadly Applicable C−N Bond Forming Dearomatization Protocol Enabled by Bifunctional Amino Reagents by Ma, Xiaofeng, Farndon, Joshua J., Young, Tom A., Fey, Natalie, Bower, John F.

“…A C−N bond forming dearomatization protocol with broad scope is outlined. Specifically, bifunctional amino reagents are used for sequential nucleophilic and…”
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Branch-Selective, Iridium-Catalyzed Hydroarylation of Monosubstituted Alkenes via a Cooperative Destabilization Strategy by Crisenza, Giacomo E. M, McCreanor, Niall G, Bower, John F

“…Highly branch-selective, carbonyl-directed hydro­aryl­ations of mono­substituted alkenes are described. The chemistry relies upon a cationic Ir­(I) catalyst…”
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Stereospecific Alkene Aziridination Using a Bifunctional Amino-Reagent: An Aza-Prilezhaev Reaction by Farndon, Joshua J, Young, Tom A, Bower, John F

“…In situ deprotection (TFA) of O-Ts activated N-Boc hydroxylamines triggers intramolecular aziridination of N-tethered alkenes to provide complex N-heterocyclic…”
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Pyrrolidines and Piperidines by Ligand‐Enabled Aza‐Heck Cyclizations and Cascades of N‐(Pentafluorobenzoyloxy)carbamates by Hazelden, Ian R., Carmona, Rafaela C., Langer, Thomas, Pringle, Paul G., Bower, John F.

“…Ligand‐enabled aza‐Heck cyclizations and cascades of N‐(pentafluorobenzoyloxy)carbamates are described. These studies encompass the first examples of efficient…”
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Copper catalyzed Heck-like cyclizations of oxime esters by Faulkner, Adele, Race, Nicholas J., Scott, James S., Bower, John F.

“…Copper catalyzed Heck-like cyclizations of oxime esters are described. Mechanistic studies indicate a reaction pathway that proceeds via the generation and…”
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Branch-Selective Alkene Hydroarylation by Cooperative Destabilization: Iridium-Catalyzed ortho-Alkylation of Acetanilides by Crisenza, Giacomo E. M., Sokolova, Olga O., Bower, John F.

“…An iridium(I) catalyst system, modified with the wide‐bite‐angle and electron‐deficient bisphosphine dFppb (1,4‐bis(di(pentafluorophenyl)phosphino)butane)…”
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Catalytic Carbonyl Addition through Transfer Hydrogenation: A Departure from Preformed Organometallic Reagents by Bower, John F., Kim, In Su, Patman, Ryan L., Krische, Michael J.

“…Classical protocols for carbonyl allylation, propargylation and vinylation typically rely upon the use of preformed allyl metal, allenyl metal and vinyl metal…”
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Oxidative Addition, Transmetalation, and Reductive Elimination at a 2,2′-Bipyridyl-Ligated Gold Center by Harper, Matthew J, Arthur, Christopher J, Crosby, John, Emmett, Edward J, Falconer, Rosalyn L, Fensham-Smith, Andrew J, Gates, Paul J, Leman, Thomas, McGrady, John E, Bower, John F, Russell, Christopher A

“…Three-coordinate bipyridyl complexes of gold, [(κ2-bipy)­Au­(η2-C2H4)]­[NTf2], are readily accessed by direct reaction of 2,2′-bipyridine (bipy), or its…”
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Rhodacyclopentanones as Linchpins for the Atom Economical Assembly of Diverse Polyheterocycles by Wang, Gang-Wei, Boyd, Olivia, Young, Tom A, Bertrand, Sophie M, Bower, John F

“…We outline a conceptual blueprint that provides direct and atom economical access to a wide range of complex polyheterocycles. Our method capitalizes on the…”
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Modular Access to Substituted Azocanes via a Rhodium-Catalyzed Cycloaddition–Fragmentation Strategy by Shaw, Megan H, Croft, Rosemary A, Whittingham, William G, Bower, John F

“…A short entry to substituted azocanes by a Rh-catalyzed cycloaddition–fragmentation process is described. Specifically, exposure of diverse…”
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