Search Results - "Bowen, Timothy"

MicroRNAs in Diabetic Nephropathy: From Biomarkers to Therapy by Simpson, Kate, Wonnacott, Alexa, Fraser, Donald J., Bowen, Timothy

“…Recent estimates suggest that 1 in 12 of the global population suffers from diabetes mellitus. Approximately 40 % of those affected will go on to develop…”
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MicroRNAs, transforming growth factor beta-1, and tissue fibrosis by Bowen, Timothy, Jenkins, Robert H, Fraser, Donald J

“…MicroRNAs are short noncoding RNA regulators that repress synthesis of their targets post‐transcriptionally. On average, each microRNA is estimated to regulate…”
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Transforming Growth Factor-β1 (TGF-β1)-stimulated Fibroblast to Myofibroblast Differentiation Is Mediated by Hyaluronan (HA)-facilitated Epidermal Growth Factor Receptor (EGFR) and CD44 Co-localization in Lipid Rafts by Midgley, Adam C., Rogers, Mathew, Hallett, Maurice B., Clayton, Aled, Bowen, Timothy, Phillips, Aled O., Steadman, Robert

“…Fibroblast to myofibroblast differentiation drives effective wound healing and is largely regulated by the cytokine transforming growth factor-β1 (TGF-β1)…”
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Natural Antisense Transcript for Hyaluronan Synthase 2 (HAS2-AS1) Induces Transcription of HAS2 via Protein O-GlcNAcylation by Vigetti, Davide, Deleonibus, Sara, Moretto, Paola, Bowen, Timothy, Fischer, Jens W., Grandoch, Maria, Oberhuber, Alexander, Love, Dona C., Hanover, John A., Cinquetti, Raffaella, Karousou, Eugenia, Viola, Manuela, D'Angelo, Maria Luisa, Hascall, Vincent C., De Luca, Giancarlo, Passi, Alberto

“…Changes in the microenvironment organization within vascular walls are critical events in the pathogenesis of vascular pathologies, including atherosclerosis…”
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Sex-specific proximal tubular cell differentiation pathways identified by single-nucleus RNA sequencing by Lu, Yueh-An, Smith, Tanya, Deshpande, Sumukh, Liao, Chia-Te, Talabani, Bnar, Grigorieva, Irina, Mason, Anna, Andrews, Robert, Bowen, Timothy, Taylor, Philip R., Fraser, Donald

“…Postnatal kidney growth is substantial and involves expansion in kidney tubules without growth of new nephrons, which are the functional units of the kidney…”
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Involvement of Hyaluronan in Regulation of Fibroblast Phenotype by Meran, Soma, Thomas, David, Stephens, Philip, Martin, John, Bowen, Timothy, Phillips, Aled, Steadman, Robert

“…This study aimed to understand the role of the matrix polysaccharide, hyaluronan (HA), in influencing the scarring process by assessing its impact on…”
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Neutrophil-derived miR-223 as local biomarker of bacterial peritonitis by Brook, Amy C., Jenkins, Robert H., Clayton, Aled, Kift-Morgan, Ann, Raby, Anne-Catherine, Shephard, Alex P., Mariotti, Barbara, Cuff, Simone M., Bazzoni, Flavia, Bowen, Timothy, Fraser, Donald J., Eberl, Matthias

“…Infection remains a major cause of morbidity, mortality and technique failure in patients with end stage kidney failure who receive peritoneal dialysis (PD)…”
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Determination of a microRNA signature of protective kidney ischemic preconditioning originating from proximal tubules by Khalid, Usman, Jenkins, Robert H., Andrews, Robert, Pino-Chavez, Gilda, Cossins, Benjamin C., Chavez, Rafael, Bowen, Timothy, Fraser, Donald J.

“…Ischemic preconditioning (IPC) is effective in limiting subsequent ischemic acute kidney injury in experimental models. MicroRNAs are an important class of…”
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The art of apportionment: working out responsibility for health care misadventures by Bowen, Timothy

“…When something goes wrong in the provision of health care, it is often unclear who might be at fault, and whether they actually are at fault. A necessity and…”
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The Human Hyaluronan Synthase 2 (HAS2) Gene and Its Natural Antisense RNA Exhibit Coordinated Expression in the Renal Proximal Tubular Epithelial Cell by Michael, Daryn R., Phillips, Aled O., Krupa, Aleksandra, Martin, John, Redman, James E., Altaher, Abdalsamed, Neville, Rachel D., Webber, Jason, Kim, Min-young, Bowen, Timothy

“…Aberrant expression of the human hyaluronan synthase 2 (HAS2) gene has been implicated in the pathology of malignancy, pulmonary arterial hypertension,…”
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miR-141 mediates recovery from acute kidney injury by Newbury, Lucy J., Simpson, Kate, Khalid, Usman, John, Imogen, de Rivera, Lluís Bailach, Lu, Yueh-An, Lopez-Anton, Melisa, Watkins, William J., Jenkins, Robert H., Fraser, Donald J., Bowen, Timothy

“…Acute kidney injury (AKI) is a global clinical problem characterised by a sudden decline in renal function and mortality as high as 60%. Current AKI biomarkers…”
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Thyrotropin Receptor Activation Increases Hyaluronan Production in Preadipocyte Fibroblasts by Zhang, Lei, Bowen, Timothy, Grennan-Jones, Fiona, Paddon, Carol, Giles, Peter, Webber, Jason, Steadman, Robert, Ludgate, Marian

“…The thyrotropin receptor (TSHR) is expressed during lineage-specific differentiation (e.g. adipogenesis) and is activated by TSH, thyroid-stimulating…”
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Post-transcriptional regulation of Transforming Growth Factor Beta-1 by microRNA-744 by Martin, John, Jenkins, Robert H, Bennagi, Rasha, Krupa, Aleksandra, Phillips, Aled O, Bowen, Timothy, Fraser, Donald J

“…Transforming Growth Factor Beta-1 (TGF-β1) is a pleiotropic cytokine that is of central importance in wound healing, inflammation, and in key pathological…”
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Age-Related Changes in Pericellular Hyaluronan Organization Leads to Impaired Dermal Fibroblast to Myofibroblast Differentiation by Simpson, Russell M.L, Meran, Soma, Thomas, David, Stephens, Philip, Bowen, Timothy, Steadman, Robert, Phillips, Aled

“…We have previously demonstrated that transforming growth factor-β1 (TGF-β1)-mediated fibroblast-myofibroblast differentiation is associated with accumulation…”
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Transforming growth factor β1 represses proximal tubular cell microRNA-192 expression through decreased hepatocyte nuclear factor DNA binding by Jenkins, Robert H, Martin, John, Phillips, Aled O, Bowen, Timothy, Fraser, Donald J

“…miR (microRNA)-192 plays key roles in renal pathological and physiological responses, by repressing targets including Zeb1, Zeb2 and Wnk1. In the present…”
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Biogenesis, Stabilization, and Transport of microRNAs in Kidney Health and Disease by Thomas, Melissa J, Fraser, Donald J, Bowen, Timothy

“…The kidneys play key roles in the maintenance of homeostasis, including fluid balance, blood filtration, erythropoiesis and hormone production. Disease-driven…”
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Pleiotropy of microRNA-192 in the kidney by Jenkins, Robert H, Martin, John, Phillips, Aled O, Bowen, Timothy, Fraser, Donald J

“…Diverse aetiologies result in significant deviation from homoeostasis in the kidney, leading to CKD (chronic kidney disease). CKD progresses to end-stage renal…”
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Using mediation in situations of withholding or withdrawing life-sustaining treatment: a New South Wales perspective by Bowen, Timothy

“…Whether to withhold or withdraw life-sustaining treatment from a person lacking competency is an extremely difficult decision for both the person's family and…”
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Overexpression of hyaluronan synthase 2 alters hyaluronan distribution and function in proximal tubular epithelial cells by SELBI, Wisam, DAY, Anthony J, RUGG, Marilyn S, FüLÖP, Csaba, DE LA MOTTE, Carol A, BOWEN, Timothy, HASCALL, Vincent C, PHILLIPS, Aled O

“…The functional consequences of increased renal cortical hyaluronan that is associated with both acute injury and progressive scarring are unclear. The aim of…”
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Mnt-deficient mammary glands exhibit impaired involution and tumors with characteristics of myc overexpression by TOYO-OKA, Kazuhito, BOWEN, Timothy J, GLASS, Christopher K, EISENMAN, Robert, BING REN, HURLIN, Peter, WYNSHAW-BORIS, Anthony, HIROTSUNE, Shinji, ZIRONG LI, JAIN, Sonia, OTA, Sara, LOZACH, Laure Escoubet, GARCIA BASSETT, Ivan, LOZACH, Jean, ROSENFELD, Michael G

“…The proto-oncogene c-Myc plays a central role in cell growth and the development of human tumors. c-Myc interacts with Max and Myc-Max complexes bind to E-box…”
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