Search Results - "Bowen, Scott J."

Type 2 inhibitor leads of human tropomyosin receptor kinase (hTrkA) by Subramanian, Govindan, Bowen, Scott J., Zhu, Yaqi, Roush, Nicole, Zachary, Theresa, Javens, Christopher, Williams, Tracey, Janssen, Ann, Gonzales, Andrea

“…[Display omitted] In silico virtual screening using the ligand-based ROCS approach and the commercially purchasable compound collection from the ZINC database…”
Get full text

Lead identification and characterization of hTrkA type 2 inhibitors by Subramanian, Govindan, Zhu, Yaqi, Bowen, Scott J., Roush, Nicole, White, Julie A., Huczek, Dennis, Zachary, Theresa, Javens, Christopher, Williams, Tracey, Janssen, Ann, Gonzales, Andrea

“…Virtual in silico structure-guided modeling, followed by in vitro biochemical screening of a subset of commercially purchasable compound collection resulted in…”
Get full text

Pro region engineering of nerve growth factor by deep mutational scanning enables a yeast platform for conformational epitope mapping of anti-NGF monoclonal antibodies by Medina-Cucurella, Angélica V, Zhu, Yaqi, Bowen, Scott J, Bergeron, Lisa M, Whitehead, Timothy A

“…Nerve growth factor (NGF) plays a central role in multiple chronic pain conditions. As such, anti-NGF monoclonal antibodies (mAbs) that function by…”
Get full text

Deciphering the Allosteric Binding Mechanism of the Human Tropomyosin Receptor Kinase A (hTrkA) Inhibitors by Subramanian, Govindan, Johnson, Paul D, Zachary, Theresa, Roush, Nicole, Zhu, Yaqi, Bowen, Scott J, Janssen, Ann, Duclos, Brian A, Williams, Tracey, Javens, Christopher, Shalaly, Nancy Dekki, Molina, Daniel Martinez, Wittwer, Arthur J, Hirsch, Jeffrey L

“…Access to cryptic binding pockets or allosteric sites on a kinase that present themselves when the enzyme is in a specific conformational state offers a…”
Get full text

Pro region engineering of nerve growth factor by deep mutational scanning enables a yeast platform for conformational epitope mapping of anti‐NGF monoclonal antibodies by Medina‐Cucurella, Angélica V., Zhu, Yaqi, Bowen, Scott J., Bergeron, Lisa M., Whitehead, Timothy A.

“…Nerve growth factor (NGF) plays a central role in multiple chronic pain conditions. As such, anti‐NGF monoclonal antibodies (mAbs) that function by…”
Get full text

In Pursuit of an Allosteric Human Tropomyosin Kinase A (hTrkA) Inhibitor for Chronic Pain by Subramanian, Govindan, Duclos, Brian, Johnson, Paul D, Williams, Tracey, Ross, Jason T, Bowen, Scott J, Zhu, Yaqi, White, Julie A, Hedke, Carolyn, Huczek, Dennis, Collard, Wendy, Javens, Christopher, Vairagoundar, Rajendran, Respondek, Tomasz, Zachary, Theresa, Maddux, Todd, Cox, Mark R, Kamerling, Steven, Gonzales, Andrea J

“…Human β-nerve growth factor (β-NGF) and its associated receptor, human tropomyosin receptor kinase A (hTrkA), have been demonstrated to be key factors in the…”
Get full text

Synthetic inhibitor leads of human tropomyosin receptor kinase A (TrkA) by Subramanian, Govindan, Vairagoundar, Rajendran, Bowen, Scott J, Roush, Nicole, Zachary, Theresa, Javens, Christopher, Williams, Tracey, Janssen, Ann, Gonzales, Andrea

“…In silico virtual screening followed by in vitro biochemical, biophysical, and cellular screening resulted in the identification of distinctly different h TrkA…”
Get full text

Discovery of novel spirocyclic inhibitors of fatty acid amide hydrolase (FAAH). Part 2. Discovery of 7-azaspiro[3.5]nonane urea PF-04862853, an orally efficacious inhibitor of fatty acid amide hydrolase (FAAH) for pain by Meyers, Marvin J., Long, Scott A., Pelc, Matthew J., Wang, Jane L., Bowen, Scott J., Schweitzer, Barbara A., Wilcox, Mark V., McDonald, Joseph, Smith, Sarah E., Foltin, Susan, Rumsey, Jeanne, Yang, Young-Sun, Walker, Mark C., Kamtekar, Satwik, Beidler, David, Thorarensen, Atli

“…Fatty acid amide hydrolase (FAAH) is an integral membrane serine hydrolase responsible for the degradation of fatty acid amide signaling molecules such as…”
Get full text

Discovery of novel spirocyclic inhibitors of fatty acid amide hydrolase (FAAH). Part 1: Identification of 7-azaspiro[3.5]nonane and 1-oxa-8-azaspiro[4.5]decane as lead scaffolds by Meyers, Marvin J., Long, Scott A., Pelc, Matthew J., Wang, Jane L., Bowen, Scott J., Walker, Mark C., Schweitzer, Barbara A., Madsen, Heather M., Tenbrink, Ruth E., McDonald, Joseph, Smith, Sarah E., Foltin, Susan, Beidler, David, Thorarensen, Atli

“…Herein we report the identification of two new fatty acid amide hydrolase (FAAH) inhibitor lead series with FAAH k inact/ K i potency values greater than 1500…”
Get full text

Structure based design of novel irreversible FAAH inhibitors by Wang, Jane L., Bowen, Scott J., Schweitzer, Barbara A., Madsen, Heather M., McDonald, Joseph, Pelc, Matthew J., Tenbrink, Ruth E., Beidler, David, Thorarensen, Atli

“…The design and synthesis a series of novel FAAH irreversible azetidine urea inhibitors from PF-3845 are described. Our SAR studies allowed us to optimize this…”
Get full text

Synthetic inhibitor leads of human tropomyosin receptor kinase A (hTrkA)† †Atomic coordinates of the kinase domain of hTrkA. Ligand have been deposited in Protein Data Bank (PDB) under PDB codes 1: 6PMB; 3: 6PMA; 5: 6PME; 6: 6PMC. ‡ ‡The manuscript was written by G. S. All authors have given approval to the final version of the manuscript. § §All experimental procedures are available as part of the ESI in ref. 23–25. ¶ ¶Electronic supplementary information (ESI) available: Computational workflow by Subramanian, Govindan, Vairagoundar, Rajendran, Bowen, Scott J., Roush, Nicole, Zachary, Theresa, Javens, Christopher, Williams, Tracey, Janssen, Ann, Gonzales, Andrea

“…New h TrkA kinase domain type 2 inhibitors and mixed type 1/type 2 inhibitor leads disclosed here offers a differential starting point to investigate the…”
Get full text

Diffuse Vascular Spasm Associated With 4-Bromo-2,5-Dimethoxyamphetamine Ingestion by Bowen, J. Scott, Davis, Gary B, Kearney, Thomas E, Bardin, Joshua

“…A 39-year-old previously healthy man experienced diffuse, progressive, peripheral arterial spasm 36 hours after the ingestion of concentrated high-grade…”
Get full text