Search Results - "Bowen, DT"

Oxidative stress and the myelodysplastic syndromes by FARQUHAR, Morag J, BOWEN, David T

“…The evolution of higher organisms from anaerobic to aerobic living has promoted an elaborate mechanism of defense against potentially toxic oxidants. Many…”
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Poor response rate to a continuous schedule of Amifostine therapy for ‘low/intermediate risk’ myelodysplastic patients by BOWEN, D. T, BRUGGER, C. D, CULLIGAN, D, GELLY, K, ADLAKHA, S, GROVES, M, HEPBURN, M, KANZ, L

“…Ineffective haemopoiesis leading to cytopenia presents the major clinical management problem for patients with myelodysplasia (MDS). Preliminary studies have…”
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Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms by Malcovati, Luca, Papaemmanuil, Elli, Bowen, David T., Boultwood, Jacqueline, Della Porta, Matteo G., Pascutto, Cristiana, Travaglino, Erica, Groves, Michael J., Godfrey, Anna L., Ambaglio, Ilaria, Gallì, Anna, Da Vià, Matteo C., Conte, Simona, Tauro, Sudhir, Keenan, Norene, Hyslop, Ann, Hinton, Jonathan, Mudie, Laura J., Wainscoat, James S., Futreal, P. Andrew, Stratton, Michael R., Campbell, Peter J., Hellström-Lindberg, Eva, Cazzola, Mario

“…In a previous study, we identified somatic mutations of SF3B1, a gene encoding a core component of RNA splicing machinery, in patients with myelodysplastic…”
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Somatic Mutations and DNA Hypermethylation at Enhancers and Promoters Identify Distinct Subtypes within Lower-Risk Myelodysplastic Syndromes by Rombaut, David, Tekath, Tobias, Sandmann, Sarah, Crouch, Simon, de Graaf, Aniek O., Kosmider, Olivier, Tobiasson, Magnus, Lennartsson, Andreas, Van der Reijden, Bert A., Park, Sophie, D'Aveni, Maud, Slama, Bohrane, Clappier, Emmanuelle, Fenaux, Pierre, Ades, Lionel, van de Loosdrecht, Arjan A., Langemeijer, Saskia MC, Symeonidis, Argiris S., Čermák, Jaroslav, Preudhomme, Claude, Savic, Aleksandar, Germing, Ulrich, Stauder, Reinhard, Bowen, David T., Van Marrewijk, Corine J., Bernard, Elsa, Smith, Alexandra, Painter, Daniel, de Witte, Theo J.M., Hellstrom Lindberg, Eva, Varghese, Julian, Dugas, Martin, Martens, Joost H.A., Malcovati, Luca, Jansen, Joop H., Fontenay, Michaela

“…Myelodysplastic syndromes (MDS) are a group of heterogeneous disorders caused by the accumulation of somatic mutations in the hematopoietic stem and progenitor…”
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The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials by Kottaridis, Panagiotis D., Gale, Rosemary E., Frew, Marion E., Harrison, Georgina, Langabeer, Stephen E., Belton, Andrea A., Walker, Helen, Wheatley, Keith, Bowen, David T., Burnett, Alan K., Goldstone, Anthony H., Linch, David C.

“…In acute myeloid leukemia (AML), further prognostic determinants are required in addition to cytogenetics to predict patients at increased risk of relapse…”
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RAS mutation in acute myeloid leukemia is associated with distinct cytogenetic subgroups but does not influence outcome in patients younger than 60 years by Bowen, David T., Frew, Marion E., Hills, Robert, Gale, Rosemary E., Wheatley, Keith, Groves, Michael J., Langabeer, Stephen E., Kottaridis, Panagiotis D., Moorman, Anthony V., Burnett, Alan K., Linch, David C.

“…The pathogenesis of acute myeloid leukemia (AML) involves the cooperation of mutations promoting proliferation/survival and those impairing differentiation…”
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Cardiac iron overload assessed by T2magnetic resonance imaging and cardiac function in regularly transfused myelodysplastic syndrome patients by Bowen, DT, Hellstrom-Lindberg, E, Steensma, DP

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Studies of FLT3 mutations in paired presentation and relapse samples from patients with acute myeloid leukemia: implications for the role of FLT3 mutations in leukemogenesis, minimal residual disease detection, and possible therapy with FLT3 inhibitors by KOTTARIDIS, Panagiotis D, GALE, Rosemary E, LANGABEER, Stephen E, FREW, Marion E, BOWEN, David T, LINCH, David C

“…FLT3 mutations, either internal tandem duplications (ITDs) or aspartate residue 835 (D835) point mutations, are present in approximately one third of patients…”
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Cardiac iron overload assessed by T2 magnetic resonance imaging and cardiac function in regularly transfused myelodysplastic syndrome patients by Bowen, David T., Hellström‐Lindberg, Eva, Steensma, David P.

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A pilot study of antithymocyte globulin (ATG) in the treatment of patients with ‘low‐risk’ myelodysplasia by Killick, Sally B., Mufti, Ghulam, Cavenagh, Jamie D., Mijovic, Alex, Peacock, Janet L., Gordon‐Smith, Edward C., Bowen, David T., Marsh, Judith C. W.

“…We report 30 ‘low‐risk’ patients with myelodysplasia (MDS) (defined as < 10% bone marrow blasts) who were treated with antithymocyte globulin (ATG). In total,…”
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Aberrant methylation of the negative regulators RASSFIA, SHP‐1 and SOCS‐1 in myelodysplastic syndromes and acute myeloid leukaemia by Johan, M. F., Bowen, D. T., Frew, M. E., Goodeve, A. C., Reilly, J. T.

“…Summary Mutations in the receptor tyrosine kinase (RTK/RAS) signalling pathway frequently provide a proliferative signal in myeloid malignancies. However, the…”
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Pathogenesis, etiology and epidemiology of myelodysplastic syndromes by Aul, C, Bowen, D T, Yoshida, Y

“…The myelodysplastic syndromes are common hematological malignancies affecting predominantly elderly people. Patients usually present with chronic cytopenias…”
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Etiology of Acute Myeloid Leukemia in the Elderly by Bowen, David T.

“…The biologic and epidemiologic study of acute myeloid leukaemia (AML) in the elderly is in its infancy. Most epidemiologic data attempting to ascertain the…”
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Time-dependent prognostic scoring system for myelodysplastic syndromes has significant limitations that may influence its reproducibility and practical application by Bowen, David T, Fenaux, Pierre, Hellstrom-Lindberg, Eva, de Witte, Theo

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Treatment Strategies and Issues in Low/Intermediate-1–Risk Myelodysplastic Syndrome (MDS) Patients by Bowen, David T.

“…Myelodysplastic syndromes (MDS) are a heterogeneous group of progressive bone marrow neoplastic disorders associated with increased risk for transformation to…”
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Population-based demographic study of karyotypes in 1709 patients with adult Acute Myeloid Leukemia by SANDERSON, R. N, JOHNSON, P. R. E, MOORMAN, A. V, ROMAN, E, WILLETT, E, TAYLOR, P. R, PROCTOR, S. J, BOWN, N, OGSTON, S, BOWEN, D. T

“…Few large demographic studies of acute myeloid leukemia (AML) are derived from population-based registries. Demographic and karyotypic data were provided for…”
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Chronic myelomonocytic leukemia: lost in classification? by Bowen, David T

“…Chronic myelomonocytic leukemia (CMML) comprises a spectrum of disease variably considered as a myelodysplastic (MDS) and/or myeloproliferative (MPD) disorder…”
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Second hit mutations in the RTK/RAS signaling pathway in acute myeloid leukemia with inv(16) by Valk, Peter J M, Bowen, David T, Frew, Marion E, Goodeve, Anne C, Löwenberg, Bob, Reilly, John T

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JAK2 V617F Mutation is uncommon in chronic myelomonocytic leukaemia by Johan, M. F., Goodeve, A. C., Bowen, D. T., Frew, M. E., Reilly, J. T.

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NRAS, FLT3 and TP53 mutations in patients with myelodysplastic syndrome and a del(5q) by Fidler, C, Watkins, F, Bowen, DT, Littlewood, TJ, Wainscoat, JS, Boultwood, J

“…Mutations of the NRAS and TP53 genes and internal tandem duplication (ITD) of the FLT3 gene are among the most frequently observed molecular abnormalities in…”
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