Search Results - "Bowden, Gregory D."

Radiochemistry: A Hot Field with Opportunities for Cool Chemistry by Bowden, Gregory D., Scott, Peter J. H., Boros, Eszter

“…Recent Food and Drug Administration (FDA) approval of diagnostic and therapeutic radiopharmaceuticals and concurrent miniaturization of particle accelerators…”
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The Structural Combination of SIL and MODAG Scaffolds Fails to Enhance Binding to α-Synuclein but Reveals Promising Affinity to Amyloid β by Di Nanni, Adriana, Saw, Ran Sing, Bowden, Gregory D, Bidesi, Natasha S R, Bjerregaard-Andersen, Kaare, Korat, Špela, Herth, Matthias M, Pichler, Bernd J, Herfert, Kristina, Maurer, Andreas

“…A technique to image α-synuclein (αSYN) fibrils in vivo is an unmet scientific and clinical need that would represent a transformative tool in the…”
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Discovery and characterization of prolactin neutralizing monoclonal antibodies for the treatment of female-prevalent pain disorders by Maciuba, Stephanie, Bowden, Gregory D., Stratton, Harrison J., Wisniewski, Kazimierz, Schteingart, Claudio D., Almagro, Juan C., Valadon, Philippe, Lowitz, Joshua, Glaser, Scott M., Lee, Grace, Dolatyari, Mahdi, Navratilova, Edita, Porreca, Frank, Rivière, Pierre J.M.

“…Prolactin (PRL) has recently been demonstrated to elicit female-selective nociceptor sensitization and increase pain-like behaviors in female animals. Here we…”
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High-Throughput Screening of a Marine Compound Library Identifies Anti- Cryptosporidium Activity of Leiodolide A by Bone Relat, Rachel M, Winder, Priscilla L, Bowden, Gregory D, Guzmán, Esther A, Peterson, Tara A, Pomponi, Shirley A, Roberts, Jill C, Wright, Amy E, O'Connor, Roberta M

“…sp. are apicomplexan parasites that cause significant morbidity and possible mortality in humans and valuable livestock. There are no drugs on the market that…”
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Covalent 18F-Radiotracers for SNAPTag: A New Toolbox for Reporter Gene Imaging by Stotz, Sophie, Bowden, Gregory D., Cotton, Jonathan M., Pichler, Bernd J., Maurer, Andreas

“…There is a need for versatile in vivo nuclear imaging reporter systems to foster preclinical and clinical research. We explore the applicability of the SNAPTag…”
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Advancing Parkinson’s Disease Diagnostics: The Potential of Arylpyrazolethiazole Derivatives for Imaging α‑Synuclein Aggregates by Bonanno, Federica, Saw, Ran Sing, Bleher, Daniel, Papadopoulos, Ioannis, Bowden, Gregory D., Bjerregaard-Andersen, Kaare, Windhorst, Albert D., Pichler, Bernd J., Herfert, Kristina, Maurer, Andreas

“…The development of positron emission tomography (PET) tracers capable of detecting α-synuclein (α-syn) aggregates in vivo would represent a breakthrough for…”
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A Design of Experiments (DoE) Approach Accelerates the Optimization of Copper-Mediated 18F-Fluorination Reactions of Arylstannanes by Bowden, Gregory D., Pichler, Bernd J., Maurer, Andreas

“…Recent advancements in 18 F radiochemistry, such as the advent of copper-mediated radiofluorination (CMRF) chemistry, have provided unprecedented access to…”
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A Fluorescent Probe as a Lead Compound for a Selective α‑Synuclein PET Tracer: Development of a Library of 2‑Styrylbenzothiazoles and Biological Evaluation of [18F]PFSB and [18F]MFSB by Di Nanni, Adriana, Saw, Ran Sing, Battisti, Umberto M., Bowden, Gregory D., Boeckermann, Adam, Bjerregaard-Andersen, Kaare, Pichler, Bernd J., Herfert, Kristina, Herth, Matthias M., Maurer, Andreas

“…A method to detect and quantify aggregated α-synuclein (αSYN) fibrils in vivo would drastically impact the current understanding of multiple neurodegenerative…”
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High-throughput screen of drug repurposing library identifies inhibitors of Sarcocystis neurona growth by Bowden, Gregory D., Land, Kirkwood M., O'Connor, Roberta M., Fritz, Heather M.

“…The apicomplexan parasite Sarcocystis neurona is the primary etiologic agent of equine protozoal myeloencephalitis (EPM), a serious neurologic disease of…”
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A conserved coccidian gene is involved in Toxoplasma sensitivity to the anti-apicomplexan compound, tartrolon E by Bowden, Gregory D., Reis, Patricia M., Rogers, Maxwell B., Bone Relat, Rachel M., Brayton, Kelly A., Wilson, Sarah K., Di Genova, Bruno Martorelli, Knoll, Laura J., Nepveux V, Felix J., Tai, Albert K., Ramadhar, Timothy R., Clardy, Jon, O'Connor, Roberta M.

“…New treatments for the diseases caused by apicomplexans are needed. Recently, we determined that tartrolon E (trtE), a secondary metabolite derived from a…”
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2-Nitroimidazole-Furanoside Derivatives for Hypoxia Imaging—Investigation of Nucleoside Transporter Interaction, 18F-Labeling and Preclinical PET Imaging by Maier, Florian, Schweifer, Anna, Damaraju, Vijaya, Cass, Carol, Bowden, Gregory, Ehrlichmann, Walter, Kneilling, Manfred, Pichler, Bernd, Hammerschmidt, Friedrich, Reischl, Gerald

“…The benefits of PET imaging of tumor hypoxia in patient management has been demonstrated in many examples and with various tracers over the last years…”
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DoE Optimization Empowers the Automated Preparation of Enantiomerically Pure [18F]Talazoparib and its In Vivo Evaluation as a PARP Radiotracer by Bowden, Gregory D, Stotz, Sophie, Kinzler, Johannes, Geibel, Christian, Lämmerhofer, Michael, Pichler, Bernd J, Maurer, Andreas

“…Given the clinical potential of poly­(ADP-ribose) polymerases (PARP) imaging for the detection and stratification of various cancers, the development of novel…”
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[18F]pFBC, a Covalent CLIP-Tag Radiotracer for Detection of Viral Reporter Gene Transfer in the Murine Brain by Bowden, Gregory D., Stotz, Sophie, Dunkel, Gina, Haas, Sabrina, Kimmerle, Elena, Schaller, Martin, Weigelin, Bettina, Herfert, Kristina, Pichler, Bernd J., Maurer, Andreas

“…Preclinical models of neurological diseases and gene therapy are essential for neurobiological research. However, the evaluation of such models lacks reliable…”
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[ 18 F] p FBC, a Covalent CLIP-Tag Radiotracer for Detection of Viral Reporter Gene Transfer in the Murine Brain by Bowden, Gregory D, Stotz, Sophie, Dunkel, Gina, Haas, Sabrina, Kimmerle, Elena, Schaller, Martin, Weigelin, Bettina, Herfert, Kristina, Pichler, Bernd J, Maurer, Andreas

“…Preclinical models of neurological diseases and gene therapy are essential for neurobiological research. However, the evaluation of such models lacks reliable…”
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Room-Temperature Photochemical Copper-Mediated Fluorination of Aryl Iodides by Spiller, Taylor E., Donabauer, Karsten, Brooks, Allen F., Witek, Jason A., Bowden, Gregory D., Scott, Peter J. H., Sanford, Melanie S.

“…This report describes a method for the photochemical Cu-mediated fluorination of aryl iodides with AgF via putative aryl radical (Ar•) intermediates. It…”
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Photo- and Cu-Mediated 11C Cyanation of (Hetero)Aryl Thianthrenium Salts by Cheng, Kevin, Webb, E. William, Bowden, Gregory D., Wright, Jay S., Shao, Xia, Sanford, Melanie S., Scott, Peter J. H.

“…We present a photo- and Cu-mediated 11C cyanation of bench-stable (hetero)­aryl thianthrenium salts via an aryl radical addition pathway. The thianthrenium…”
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Photo- and Cu-Mediated 11 C Cyanation of (Hetero)Aryl Thianthrenium Salts by Cheng, Kevin, Webb, E William, Bowden, Gregory D, Wright, Jay S, Shao, Xia, Sanford, Melanie S, Scott, Peter J H

“…We present a photo- and Cu-mediated C cyanation of bench-stable (hetero)aryl thianthrenium salts via an aryl radical addition pathway. The thianthrenium…”
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Development of High-Throughput Experimentation Approaches for Rapid Radiochemical Exploration by Webb, E. William, Cheng, Kevin, Winton, Wade P., Klein, Brandon J.C., Bowden, Gregory D., Horikawa, Mami, Liu, S. Wendy, Wright, Jay S., Verhoog, Stefan, Kalyani, Dipannita, Wismer, Michael, Krska, Shane W., Sanford, Melanie S., Scott, Peter J.H.

“…Positron emission tomography is a widely used imaging platform for studying physiological processes. Despite the proliferation of modern synthetic…”
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A Design of Experiments (DoE) Approach Accelerates the Optimization of Copper-Mediated 18 F-Fluorination Reactions of Arylstannanes by Bowden, Gregory D, Pichler, Bernd J, Maurer, Andreas

“…Recent advancements in F radiochemistry, such as the advent of copper-mediated radiofluorination (CMRF) chemistry, have provided unprecedented access to novel…”
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2-Nitroimidazole-Furanoside Derivatives for Hypoxia Imaging-Investigation of Nucleoside Transporter Interaction, 18 F-Labeling and Preclinical PET Imaging by Maier, Florian C, Schweifer, Anna, Damaraju, Vijaya L, Cass, Carol E, Bowden, Gregory D, Ehrlichmann, Walter, Kneilling, Manfred, Pichler, Bernd J, Hammerschmidt, Friedrich, Reischl, Gerald

“…The benefits of PET imaging of tumor hypoxia in patient management has been demonstrated in many examples and with various tracers over the last years…”
Get full text