Search Results - "Bowden, D. K"

Australian guidelines for the assessment of iron overload and iron chelation in transfusion-dependent thalassaemia major, sickle cell disease and other congenital anaemias by Ho, P. J., Tay, L., Lindeman, R., Catley, L., Bowden, D. K.

“…Iron overload is the most important cause of mortality in patients with thalassaemia major. Iron chelation is therefore a critical issue in the management of…”
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Evidence for mitochondrial DNA recombination in a human population of island Melanesia by Hagelberg, E., Goldman, N., Lio, P., Whelan, S., Schiefenhovel, W., Clegg, J. B., Bowden, D. K.

“…Mitochondrial DNA (mtDNA) analysis has proved useful in studies of recent human evolution and the genetic affinities of human groups of different geographical…”
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High incidence of malaria in α-thalassaemic children by Williams, T. N, Maitland, K, Bennett, S, Ganczakowski, M, Peto, T. E. A, Newbold, C. I, Bowden, D. K, Weatherall, D. J, Clegg, J. B

“…The alpha+-thalassaemias are the commonest known human genetic disorders, affecting up to 80 per cent of some populations. Although there is good evidence from…”
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A PCR-based strategy to detect the common severe determinants of alpha thalassaemia by Bowden, D K, Vickers, M A, Higgs, D R

“…A rapid and inexpensive polymerase chain reaction (PCR) based strategy is described which detects the three common, severe alpha thalassaemia determinants…”
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The interaction between Plasmodium falciparum and P. vivax in children on Espiritu Santo island, Vanuatu by Maitland, K., Williams, T.N., Bennett, S., Newbold, C.I., Peto, T.E.A., Viji, J., Timothy, R., Clegg, J.B., Weatherall, D.J., Bowden, D.K.

“…Studies of the prevalence and incidence of malaria were conducted in children <10 years old living in 10 rural villages on the island of Espiritu Santo,…”
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The effect of gonadal status on body composition and bone mineral density in transfusion-dependent thalassemia by Wong, P., Fuller, P. J., Gillespie, M. T., Kartsogiannis, V., Milat, F., Bowden, D. K., Strauss, B. J.

“…Summary Patients with transfusion-dependent thalassemia have abnormal growth, hormonal deficits, and increased bone loss. We investigated the relationship…”
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Multiple glucose 6-phosphate dehydrogenase-deficient variants correlate with malaria endemicity in the Vanuatu Archipelago (southwestern Pacific) by GANCZAKOWSKI, M, TOWN, M, BOWDEN, D. K, VULLIAMY, T. J, KANEKO, A, CLEGG, J. B, WEATHERALL, D. J, LUZZATTO, L

“…In studying the relationship between genetic abnormalities of red blood cells and malaria endemicity in the Vanuatu archipelago in the southwestern Pacific, we…”
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Evidence for mitochondrial DNA recombination in a human population of island Melanesia: correction by Hagelberg, E., Goldman, N., Lio, P., Whelan, S., Schiefenhovel, W., Clegg, J. B., Bowden, D. K.

“…We recently presented evidence of mitochondrial DNA recombination in humans based on the observation of a rare mutation in several unrelated human lineages in…”
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Absence of malaria-specific mortality in children in an area of hyperendemic malaria by Maitland, K., Williams, T.N., Peto, T.E.A., Day, K.P., Clegg, J.B., Weatherall, D.J., Bowden, D.K.

“…We conducted a prospective community-based malaria surveillance study on a cohort of children <10 years old living in an area of hyperendemic malaria (spleen…”
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Red blood cell phenotypes in the alpha + thalassaemias from early childhood to maturity by Williams, T N, Maitland, K, Ganczakowski, M, Peto, T E, Clegg, J B, Weatherall, D J, Bowden, D K

“…The alpha+ thalassaemias are the most common single gene disorders of humans, yet little is known about their haematological characteristics in childhood…”
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High frequencies of α -thalassaemia are the result of natural selection by malaria by Flint, J, Hill, A. V. S, Bowden, D. K, Oppenheimer, S. J, Sill, P. R, Serjeantson, S. W, Bana-Koiri, J, Bhatia, K, Alpers, M. P, Boyce, A. J, Weatherall, D. J, Clegg, J. B

“…The frequency of alpha+-thalassaemia, but not other unlinked DNA polymorphisms, exhibits an altitude- and latitude-dependent correlation with malaria…”
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Plasmodium vivax: a cause of malnutrition in young children by Williams, T.N., Maitland, K., Phelps, L., Bennett, S., Peto, T.E.A., Viji, J., Timothy, R., Clegg, J.B., Weatherall, D.J., Bowden, D.K.

“…We studied the aetiology of malnutrition in a cohort of 1511 children <10 years old in Espiritu Santo, Vanuatu. Malnutrition was categorized using standard…”
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Reduced soluble transferrin receptor concentrations in acute malaria in Vanuatu by Williams, T N, Maitland, K, Rees, D C, Peto, T E, Bowden, D K, Weatherall, D J, Clegg, J B

“…Soluble transferrin receptor (sTfR) concentration is a sensitive index of iron deficiency when used in conjunction with ferritin measurements in adults. One…”
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A randomized, double-blind, placebo-controlled trial of intravenous zoledronic acid in the treatment of thalassemia-associated osteopenia by Gilfillan, C P, Strauss, B J S, Rodda, C P, Bowden, D K, Kean, A-M, Obaid, M, Crawford, B A

“…Beta-thalassaemia major is associated with low bone mass and fractures. We conducted a 2 year randomized controlled trial of zoledronic acid 4 mg administered…”
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Thalassaemia in Vanuatu, south-west Pacific: frequency and haematological phenotypes of young children by Ganczakowski, M, Bowden, D K, Maitland, K, Williams, T N, O'Shaughnessy, D, Viji, J, Lucassen, A, Clegg, J B, Weatherall, D J

“…The archipelago of Vanuatu situated in the South-West Pacific has a high frequency of alpha + thalassaemia and additionally on some of the islands there is a…”
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Antenatal screening and prenatal diagnosis of thalassaemia by Hendy, Jean G, Monagle, Paul T, Bowden, Don K

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DNA fingerprinting in relation to male dominance and paternity in a captive colony of tammar wallabies (Macropus eugenii) by Ewen, K R, Temple-Smith, P D, Bowden, D K, Marinopoulos, J, Renfree, M B, Yan, H

“…The tammar wallaby has a polygynous mating system in which the dominant male usually controls initial access to oestrous females by mating first and then…”
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Melanesians and Polynesians share a unique α-Thalassemia mutation by HILL, A. V. S, BOWDEN, D. K, TRENT, R. J, HIGGS, D. R, OPPENHEIMER, S. J, THEIN, S. L, MICKLESON, K. N. P, WEATHERALL, D. J, CLEGG, J. B

“…Several genetic markers that provide information on population migrations and affinities have been detected by studies of proteins and cellular antigens in…”
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Globin genes in Micronesia: origins and affinities of Pacific Island peoples by O'Shaughnessy, D F, Hill, A V, Bowden, D K, Weatherall, D J, Clegg, J B

“…DNA polymorphisms and copy-number variants of alpha-, zeta-, and gamma-globin genes have been studied in seven Micronesian island populations and have been…”
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Studies to detect carriers of haemophilia A in German shepherd dogs using diagnostic DNA polymorphisms in the human factor VIII gene by Clark, P, Bowden, D K, Parry, B W

“…The current study investigated whether the DNA polymorphisms in the human FVIII gene, that are used for the diagnosis of carriers of haemophilia A, were…”
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