Search Results - "Boverhof, R"

Comparative assessment of nanomaterial definitions and safety evaluation considerations by Boverhof, Darrell R., Bramante, Christina M., Butala, John H., Clancy, Shaun F., Lafranconi, Mark, West, Jay, Gordon, Steve C.

“…Nanomaterials continue to bring promising advances to science and technology. In concert have come calls for increased regulatory oversight to ensure their…”
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Nanomaterial characterization: considerations and needs for hazard assessment and safety evaluation by Boverhof, Darrell R, David, Raymond M

“…Nanotechnology is a rapidly emerging field of great interest and promise. As new materials are developed and commercialized, hazard information also needs to…”
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Chemical respiratory allergy: Reverse engineering an adverse outcome pathway by Kimber, Ian, Dearman, Rebecca J, Basketter, David A, Boverhof, Darrell R

“…Abstract Allergic sensitisation of the respiratory tract by chemicals is associated with rhinitis and asthma and remains an important occupational health…”
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Toxicogenomics in Risk Assessment: Applications and Needs by Boverhof, Darrell R., Zacharewski, Timothy R.

“…Since its inception, there have been high expectations for the science of toxicogenomics to decrease the uncertainties associated with the risk assessment…”
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Investigation of potential early key events and mode of action for 1,2‐dichloroethane‐induced mammary tumors in female rats by LeBaron, Matthew J., Hotchkiss, Jon A., Zhang, Fagen, Koehler, Matthew W., Boverhof, Darrell R.

“…1,2‐dichloroethane (DCE or EDC) is a chlorinated hydrocarbon used as a chemical intermediate, including in the synthesis of polyvinyl chloride. Although DCE…”
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Transgenic animal models in toxicology: historical perspectives and future outlook by Boverhof, Darrell R, Chamberlain, Mark P, Elcombe, Clifford R, Gonzalez, Frank J, Heflich, Robert H, Hernández, Lya G, Jacobs, Abigail C, Jacobson-Kram, David, Luijten, Mirjam, Maggi, Adriana, Manjanatha, Mugimane G, Benthem, Jan van, Gollapudi, B Bhaskar

“…Transgenic animal models are powerful tools for developing a more detailed understanding on the roles of specific genes in biological pathways and systems…”
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Comparative Toxicogenomic Analysis of the Hepatotoxic Effects of TCDD in Sprague Dawley Rats and C57BL/6 Mice by Boverhof, Darrell R., Burgoon, Lyle D., Tashiro, Colleen, Sharratt, Bonnie, Chittim, Brock, Harkema, Jack R., Mendrick, Donna L., Zacharewski, Timothy R.

“…In an effort to further characterize conserved and species-specific mechanisms of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)–mediated toxicity, comparative…”
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Comparative analysis of dioxin response elements in human, mouse and rat genomic sequences by Sun, Y. V., Boverhof, D. R., Burgoon, L. D., Fielden, M. R., Zacharewski, T. R.

“…Comparative approaches were used to identify human, mouse and rat dioxin response elements (DREs) in genomic sequences unambiguously assigned to a nucleotide…”
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Differential gene expression responses distinguish contact and respiratory sensitizers and nonsensitizing irritants in the local lymph node assay by Adenuga, David, Woolhiser, Michael R, Gollapudi, B Bhaskar, Boverhof, Darrell R

“…Genomic approaches have the potential to enhance the specificity and predictive accuracy of existing toxicology endpoints, including those for chemical…”
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Toxicogenomic evaluation of long-term hepatic effects of TCDD in immature, ovariectomized C57BL/6 mice by Kopec, Anna K, Boverhof, Darrell R, Nault, Rance, Harkema, Jack R, Tashiro, Colleen, Potter, Dave, Sharratt, Bonnie, Chittim, Brock, Zacharewski, Timothy R

“…Acute exposure to hepatotoxic doses of 2,3,7,8-tetrachloro- dibenzo-p-dioxin (TCDD) in mice is characterized by differential gene expression that can be…”
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Respiratory sensitization and allergy: Current research approaches and needs by Boverhof, Darrell R., Billington, Richard, Gollapudi, B. Bhaskar, Hotchkiss, John A., Krieger, Shannon M., Poole, Alan, Wiescinski, Connie M., Woolhiser, Michael R.

“…There are currently no accepted regulatory models for assessing the potential of a substance to cause respiratory sensitization and allergy. In contrast, a…”
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Dioxin induces an estrogen-like, estrogen receptor-dependent gene expression response in the murine uterus by Boverhof, Darrell R, Kwekel, Joshua C, Humes, Daryl G, Burgoon, Lyle D, Zacharewski, Timothy R

“…2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a ubiquitous environmental contaminant that elicits a broad range of toxicities in a tissue-, sex-, age-, and…”
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Inhibition of estrogen-mediated uterine gene expression responses by dioxin by Boverhof, Darrell R, Burgoon, Lyle D, Williams, Kurt J, Zacharewski, Timothy R

“…2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) exhibits antiestrogenic properties, including the inhibition of estrogen-induced uterine growth and proliferation…”
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Temporal and Dose-Dependent Hepatic Gene Expression Patterns in Mice Provide New Insights into TCDD-Mediated Hepatotoxicity by Boverhof, Darrell R., Burgoon, Lyle D., Tashiro, Colleen, Chittim, Brock, Harkema, Jack R., Jump, Donald B., Zacharewski, Timothy R.

“…In an effort to further characterize the mechanisms of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-mediated toxicity, comprehensive temporal and dose–response…”
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Normalization of two-channel microarray experiments: a semiparametric approach by Eckel, J. E., Gennings, C., Therneau, T. M., Burgoon, L. D., Boverhof, D. R., Zacharewski, T. R.

“…Motivation: An important underlying assumption of any experiment is that the experimental subjects are similar across levels of the treatment variable, so that…”
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Assessment of the respiratory sensitization potential of proteins using an enhanced mouse intranasal test (MINT) by Krieger, S.M., Boverhof, D.R., Woolhiser, M.R., Hotchkiss, J.A.

“…•The MINT was evaluated with additional endpoints to improve assay performance.•Assessment of airway hyperresponsiveness did not provide additional value.•BAL…”
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2,3,7,8-Tetrachlorodibenzo-p-dioxin induces suppressor of cytokine signaling 2 in murine B cells by Boverhof, Darrell R, Tam, Elaine, Harney, Allison S, Crawford, Robert B, Kaminski, Norbert E, Zacharewski, Timothy R

“…The B cell, a major component of humoral immunity, is a sensitive target for the immunotoxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), possibly by…”
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A review and perspective of existing research on the release of nanomaterials from solid nanocomposites by Froggett, Stephan J, Clancy, Shaun F, Boverhof, Darrell R, Canady, Richard A

“…Advances in adding nanomaterials to various matrices have occurred in tandem with the identification of potential hazards associated with exposure to pure…”
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Comparative Temporal Toxicogenomic Analysis of TCDD- and TCDF-Mediated Hepatic Effects in Immature Female C57BL/6 Mice by N'Jai, Alhaji, Boverhof, Darrell R., Dere, Edward, Burgoon, Lyle D., Tan, Ying S., Rowlands, J. Craig, Budinsky, Robert A., Stebbins, Kenneth E., Zacharewski, Timothy R.

“…Temporal analyses were performed on hepatic tissue from immature female C57BL/6 mice in order to compare the gene expression profiles for…”
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Temporal- and dose-dependent hepatic gene expression changes in immature ovariectomized mice following exposure to ethynyl estradiol by Boverhof, D. R., Fertuck, K. C., Burgoon, L. D., Eckel, J. E., Gennings, C., Zacharewski, T. R.

“…Temporal- and dose-dependent changes in hepatic gene expression were examined in immature ovariectomized C57BL/6 mice gavaged with ethynyl estradiol (EE), an…”
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