Search Results - "Bovee, D"

Reducing hydrophobicity of homogeneous antibody-drug conjugates improves pharmacokinetics and therapeutic index by Lyon, Robert P, Bovee, Tim D, Doronina, Svetlana O, Burke, Patrick J, Hunter, Joshua H, Neff-LaFord, Haley D, Jonas, Mechthild, Anderson, Martha E, Setter, Jocelyn R, Senter, Peter D

“…The in vivo efficacy of antibody-drug conjugates is enhanced by decreasing their hydrophobicity. The in vitro potency of antibody-drug conjugates (ADCs)…”
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Development of potent monoclonal antibody auristatin conjugates for cancer therapy by Senter, Peter D, Doronina, Svetlana O, Toki, Brian E, Torgov, Michael Y, Mendelsohn, Brian A, Cerveny, Charles G, Chace, Dana F, DeBlanc, Ron L, Gearing, R Patrick, Bovee, Tim D, Siegall, Clay B, Francisco, Joseph A, Wahl, Alan F, Meyer, Damon L

“…We describe the in vitro and in vivo properties of monoclonal antibody (mAb)-drug conjugates consisting of the potent synthetic dolastatin 10 analogs…”
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Enhanced Activity of Monomethylauristatin F through Monoclonal Antibody Delivery:  Effects of Linker Technology on Efficacy and Toxicity by Doronina, Svetlana O, Mendelsohn, Brian A, Bovee, Tim D, Cerveny, Charles G, Alley, Stephen C, Meyer, Damon L, Oflazoglu, Ezogelin, Toki, Brian E, Sanderson, Russell J, Zabinski, Roger F, Wahl, Alan F, Senter, Peter D

“…We have previously shown that antibody−drug conjugates (ADCs) consisting of cAC10 (anti-CD30) linked to the antimitotic agent monomethylauristatin E (MMAE)…”
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Complete Genome Sequence of the Genetically Tractable Hydrogenotrophic Methanogen Methanococcus maripaludis by Hendrickson, E L, Kaul, R, Zhou, Y, Bovee, D, Chapman, P, Chung, J, Conway de Macario, E, Dodsworth, J A, Gillett, W, Graham, D E, Hackett, M, Haydock, A K, Kang, A, Land, M L, Levy, R, Lie, T J, Major, T A, Moore, B C, Porat, I, Palmeiri, A, Rouse, G, Saenphimmachak, C, Söll, D, Van Dien, S, Wang, T, Whitman, W B, Xia, Q, Zhang, Y, Larimer, F W, Olson, M V, Leigh, J A

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Scan of Human Genome Reveals No New Loci Under Ancient Balancing Selection by Bubb, K. L, Bovee, D, Buckley, D, Haugen, E, Kibukawa, M, Paddock, M, Palmieri, A, Subramanian, S, Zhou, Y, Kaul, R, Green, P, Olson, M. V

“…There has been much speculation as to what role balancing selection has played in evolution. In an attempt to identify regions, such as HLA, at which…”
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Effects of Flow Regulation on Shallow‐Water Habitat Dynamics and Floodplain Connectivity by Bowen, Zachary H., Bovee, Ken D., Waddle, Terry J.

“…Our study examined the effects of flow regulation on the spatiotemporal availability of shallow habitat patches with slow current velocity (SSCV patches) and…”
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Flow and Habitat Effects on Juvenile Fish Abundance in Natural and Altered Flow Regimes by Freeman, Mary C., Bowen, Zachary H., Bovee, Ken D., Irwin, Elise R.

“…Conserving biological resources native to large river systems increasingly depends on how flow-regulated segments of these rivers are managed. Improving…”
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Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates by Lyon, Robert P, Setter, Jocelyn R, Bovee, Tim D, Doronina, Svetlana O, Hunter, Joshua H, Anderson, Martha E, Balasubramanian, Cindy L, Duniho, Steven M, Leiske, Chris I, Li, Fu, Senter, Peter D

“…A new method for linking antibodies to drugs produces conjugates with improved stability and efficacy. Many antibody-drug conjugates (ADCs) are unstable in…”
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Novel Auristatins with High Bystander and Cytotoxic Activities in Drug Efflux-positive Tumor Models by Moquist, Philip N, Bovee, Tim D, Waight, Andrew B, Mitchell, Jamie A, Miyamoto, Jamie B, Mason, Marsha L, Emmerton, Kim K, Stevens, Nicole, Balasubramanian, Cindy, Simmons, Jessica K, Lyon, Robert P, Senter, Peter D, Doronina, Svetlana O

“…Auristatins, a class of clinically validated anti-tubulin agents utilized as payloads in antibody-drug conjugates, are generally classified by their membrane…”
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Implications of flood pulse restoration for populus regeneration on the upper Missouri River by Bovee, Ken D., Scott, Michael L.

“…We developed a mass balance flow model to reconstruct unregulated daily peak flows in the National Wild and Scenic reach of the Missouri River, Montana…”
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Evaluation of Generalized Habitat Criteria for Assessing Impacts of Altered Flow Regimes on Warmwater Fishes by Bowen, Zachary H., Freeman, Mary C., Bovee, Ken D.

“…Assessing potential effects of flow regulation on southeastern warmwater fish assemblages is problematic because of high species richness and poor knowledge of…”
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Novel Peptide Linkers for Highly Potent Antibody−Auristatin Conjugate by Doronina, Svetlana O, Bovee, Tim D, Meyer, David W, Miyamoto, Jamie B, Anderson, Martha E, Morris-Tilden, Carol A, Senter, Peter D

“…Auristatins are highly potent antimitotic agents that have received considerable attention because of their activities when targeted to tumor cells in the form…”
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Comprehensive Transposon Mutant Library of Pseudomonas aeruginosa by Jacobs, Michael A., Alwood, Ashley, Thaipisuttikul, Iyarit, Spencer, David, Haugen, Eric, Ernst, Stephen, Will, Oliver, Kaul, Rajinder, Raymond, Christopher, Levy, Ruth, Chun-Rong, Liu, Guenthner, Donald, Bovee, Donald, Olson, Maynard V., Manoil, Colin

“…We have developed technologies for creating saturating libraries of sequence-defined transposon insertion mutants in which each strain is maintained…”
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High Incidence of Herpes Zoster in Renal Transplant Patients: Abstract# D2457 by Kho, M., Bovee, D., Weimar, W., Betjes, M., van Besouw, N.

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The Genome of the Natural Genetic Engineer Agrobacterium tumefaciens C58 by Wood, Derek W., Setubal, Joao C., Kaul, Rajinder, Monks, Dave E., Kitajima, Joao P., Okura, Vagner K., Zhou, Yang, Chen, Lishan, Wood, Gwendolyn E., Almeida, Nalvo F., Woo, Lisa, Chen, Yuching, Paulsen, Ian T., Eisen, Jonathan A., Karp, Peter D., Bovee, Donald, Chapman, Peter, Clendenning, James, Deatherage, Glenda, Gillet, Will, Grant, Charles, Kutyavin, Tatyana, Levy, Ruth, Li, Meng-Jin, McClelland, Erin, Palmieri, Anthony, Raymond, Christopher, Rouse, Gregory, Saenphimmachak, Channakhone, Wu, Zaining, Romero, Pedro, Gordon, David, Zhang, Shiping, Yoo, Heayun, Tao, Yumin, Biddle, Phyllis, Jung, Mark, Krespan, William, Perry, Michael, Gordon-Kamm, Bill, Liao, Li, Kim, Sun, Hendrick, Carol, Zhao, Zuo-Yu, Dolan, Maureen, Chumley, Forrest, Tingey, Scott V., Tomb, Jean-Francois, Gordon, Milton P., Olson, Maynard V., Nester, Eugene W.

“…The 5.67-megabase genome of the plant pathogen Agrobacterium tumefaciens C58 consists of a circular chromosome, a linear chromosome, and two plasmids…”
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Erratum: Development of potent monoclonal antibody auristatin conjugates for cancer therapy by Doronina, Svetlana O, Toki, Brian E, Torgov, Michael Y, Mendelsohn, Brian A, Cerveny, Charles G, Chace, Dana F, DeBlanc, Ron L, Gearing, R Patrick, Bovee, Tim D, Siegall, Clay B, Francisco, Joseph A, Wahl, Alan F, Meyer, Damon L, Senter, Peter D

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Targeted, haplotype-resolved resequencing of long segments of the human genome by Raymond, Christopher K., Subramanian, Sandhya, Paddock, Marcia, Qiu, Ruolan, Deodato, Chloe, Palmieri, Anthony, Chang, Jean, Radke, Tana, Haugen, Eric, Kas, Arnie, Waring, David, Bovee, Donald, Stacy, Robin, Kaul, Rajinder, Olson, Maynard V.

“…Currently, challenges exist to acquire long-range (hundreds of kilobase pairs) phase-discriminated sequence across substantial numbers of individuals. We have…”
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Abstract 2803: Novel auristatins with high activity on efflux-positive models and demonstrable bystander activity by Moquist, Philip N., Bovee, Tim D., Waight, Andrew B., Owen, Sarah, Mitchell, Jamie A., Zaval, Margo, Quick, Marsha, Sandall, Sharsti, Emmerton, Kim K., Blesie, Nicole, Lyon, Robert P., Senter, Peter, Doronina, Svetlana

“…Abstract Auristatins are a class of clinically validated antimitotic agents utilized as payloads in antibody-drug conjugates (ADCs). Auristatins display many…”
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Transferability of Habitat Suitability Criteria: Response to Comment by Freeman, Mary C., Bowen, Zachary H., Bovee, Ken D.

“…Williams et al. (1999) raise several methodological and philosophical issues connected with the problem of defining habitat requirements for aquatic fauna in…”
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Oral hygiene for denture patients by Bovee, D S

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