Biological study of alcohol dependence syndrome with reference to ethnic difference: report of a WHO Collaborative Study

Biological study of alcohol dependence syndrome with reference to ethnic difference: report of a WHO Collaborative Study

Inherited deficiency of acetaldehyde dehydrogenase type I (ALDH-I) was found in 43% (50/117) of normals, 33% (27/82) of schizophrenics, but only 4% (5/113) of alcoholics among Japanese. The ALDH-I deficiency was never found, however, in 146 mostly schizophrenic subjects from Europe (Basel, Moscow, Z...

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Bibliographic Details
Published in:Japanese journal of psychiatry and neurology Vol. 44; no. 1; p. 79
Main Authors: Yamashita, I, Ohmori, T, Koyama, T, Mori, H, Boyadjive, S, Kielholz, P, Gastpar, M, Moussaoui, D, Bouzekraoui, M, Sethi, B B
Format: Journal Article
Language:English
Published: Japan 01-03-1990
Subjects:
Alcoholism - enzymology
Alcoholism - ethnology
Aldehyde Oxidoreductases - deficiency
Ethanol - metabolism
Europe - ethnology
Female
Humans
Japan
Male
Mexico - ethnology
Philippines - ethnology
Schizophrenia - enzymology
Schizophrenia - ethnology
World Health Organization
Mexico
Europe
Japan
Philippines
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Summary:Inherited deficiency of acetaldehyde dehydrogenase type I (ALDH-I) was found in 43% (50/117) of normals, 33% (27/82) of schizophrenics, but only 4% (5/113) of alcoholics among Japanese. The ALDH-I deficiency was never found, however, in 146 mostly schizophrenic subjects from Europe (Basel, Moscow, Zagreb), Australia (Nedlands), India (Lucknow), Morocco (Casablanca) and Mexico (Mexico City). It was demonstrated that ALDH-I deficiency produces the flushing syndrome which inhibits the development of drinking habit and alcohol dependence syndrome.
ISSN:0912-2036