Search Results - "Bouwman, Taren"

The longitudinal kinetics of AAV5 vector integration profiles and evaluation of clonal expansion in mice by Ismail, Ashrafali Mohamed, Witt, Evan, Bouwman, Taren, Clark, Wyatt, Yates, Bridget, Franco, Matteo, Fong, Sylvia

“…Adeno-associated virus (AAV)-based vectors are used clinically for gene transfer and persist as extrachromosomal episomes. A small fraction of vector genomes…”
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Young mice administered adult doses of AAV5-hFVIII-SQ achieve therapeutic factor VIII expression into adulthood by Zhang, Lening, Yates, Bridget, Murphy, Ryan, Liu, Su, Xie, Lin, Handyside, Britta, Sihn, Choong-Ryoul, Bouwman, Taren, Galicia, Nicole, Tan, Danielle, Fonck, Carlos, Arens, Jeremy, Clark, Annie, Zhang, Weiming, Chandra, Sundeep, Srimani, Jaydeep, Holcomb, Jennifer, Van Tuyl, Andrea, Henshaw, Joshua, Vettermann, Christian, Siso, Silvia, Su, Cheng, Bullens, Sherry, Bunting, Stuart, O’Neill, Charles, Fong, Sylvia

“…Valoctocogene roxaparvovec (AAV5-hFVIII-SQ) gene transfer provided reduced bleeding for adult clinical trial participants with severe hemophilia A. However,…”
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Vector genome loss and epigenetic modifications mediate decline in transgene expression of AAV5 vectors produced in mammalian and insect cells by Handyside, Britta, Ismail, Ashrafali Mohamed, Zhang, Lening, Yates, Bridget, Xie, Lin, Sihn, Choong-Ryoul, Murphy, Ryan, Bouwman, Taren, Kim, Chan Kyu, De Angelis, Rolando, Karim, Omair A., McIntosh, Nicole L., Doss, Michael Xavier, Shroff, Shilpa, Pungor, Erno, Bhat, Vikas S., Bullens, Sherry, Bunting, Stuart, Fong, Sylvia

“…Recombinant adeno-associated virus (rAAV) vectors are often produced in HEK293 or Spodoptera frugiperda (Sf)-based cell lines. We compared expression profiles…”
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