Search Results - "Bouw, M. René"

Clinical pharmacokinetic and pharmacodynamic profile of midazolam nasal spray by Bouw, M. René, Chung, Steve S., Gidal, Barry, King, Aliceson, Tomasovic, Jerry, Wheless, James W., Van Ess, Peter J.

“…•Nasally administered midazolam is rapidly, consistently, and extensively absorbed.•Alertness and psychomotor functionality return to baseline by ∼240 min post…”
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Phase I study assessing the safety, tolerability, and pharmacokinetics of avibactam and ceftazidime–avibactam in healthy Japanese volunteers by Tominaga, Nobumitsu, Edeki, Timi, Li, James, Learoyd, Maria, Bouw, M. René, Das, Shampa

“…Abstract Avibactam is a novel non-β-lactam β-lactamase inhibitor that has been shown to restore the in vitro activity of ceftazidime against pathogens…”
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Pharmacokinetics, safety, and efficacy of mycophenolate mofetil in combination with sirolimus or ciclosporin in renal transplant patients by Pescovitz, Mark D., Vincenti, Flavio, Hart, Marquis, Melton, Larry, Whelchel, John, Mulgaonkar, Shamkant, McKay, Diane, Leung, Mimi, Calleja, Elizabeth, Bouw, M. René

“…Aims To compare the pharmacokinetics of mycophenolic acid (MPA) and its metabolite (MPAG) when mycophenolate mofetil (MMF) is administered in combination with…”
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Safety and pharmacokinetics of daclizumab in pediatric renal transplant recipients by Pescovitz, Mark D., Knechtle, Stuart, Alexander, Steven R., Colombani, Paul, Nevins, Tom, Nieforth, Keith, Bouw, M. René

“…:  This study examined the safety and pharmacokinetics/pharmacodynamics of daclizumab in combination with mycophenolate mofetil (or azathioprine),…”
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Mycophenolic Acid Exposure after Administration of Mycophenolate Mofetil in the Presence and Absence of Ciclosporin in Renal Transplant Recipients by Kuypers, Dirk R., Ekberg, Henrik, Grinyó, Josep, Nashan, Björn, Vincenti, Flavio, Snell, Paul, Mamelok, Richard D., Bouw, Rene M.

“…Background and objective: The pharmacokinetics of mycophenolic acid (MPA) are complex, with large interindividual variability over time. There are also well…”
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Blood‐brain barrier transport and brain distribution of morphine‐6‐glucuronide in relation to the antinociceptive effect in rats – pharmacokinetic/pharmacodynamic modelling by Bouw, M René, Xie, Rujia, Tunblad, Karin, Hammarlund‐Udenaes, Margareta

“…The objective of this study was to investigate the contribution of the blood‐brain barrier (BBB) transport to the delay in antinociceptive effect of…”
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Methodological aspects of the use of a calibrator in in vivo microdialysis-further development of the retrodialysis method by BOUW, M. R, HAMMARLUND-UDENAES, M

“…To investigate the performance of two alternative retrodialysis recovery methods and to describe the influence of different recoveries on the reliability in…”
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Modelling of the blood‐brain barrier transport of morphine‐3‐glucuronide studied using microdialysis in the rat: involvement of probenecid‐sensitive transport by Xie, Rujia, Bouw, M René, Hammarlund‐Udenaes, Margareta

“…The objective of this study was to investigate the impact of probenecid on the blood‐brain barrier (BBB) transport of morphine‐3‐glucuronide (M3G). Two groups…”
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Assessment of type I error rates for the statistical sub-model in NONMEM by WÄHLBY, Ulrika, BOUW, M. Rene, JONSSON, E. Niclas, KARLSSON, Mats O

“…The aim of this study was to assess the type I error rate when applying the likelihood ratio (LR) test, for components of the statistical sub-model in NONMEM…”
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Pharmacokinetic-pharmacodynamic modelling of morphine transport across the blood-brain barrier as a cause of the antinociceptive effect delay in rats: A microdialysis study by BOUW, M. René, GARDMARK, Marie, HAMMARLUND-UDENAES, Margareta

“…To quantify the contribution of distributional processes across the blood-brain barrier (BBB) to the delay in antinociceptive effect of morphine in rats…”
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Pharmacokinetics, safety, and efficacy of mycophenolate mofetil in combination with cirolimus or ciclosporin in renal transplant patients by Pescovitz, Mark D, Vincenti, Flavio, Hart, Marquis, Melton, Larry, Whelchel, John, Mulgaonkar, Shamkant, McKay, Diane, Leung, Mimi, Calleja, Elizabeth, Bouw, M René

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Mycophenolic acid exposure after administration of mycophenolate mofetil in the presence and absence of cyclosporin in renal transplant recipients by Kuypers, Dirk R, Ekberg, Henrik, Grinyó, Josep, Nashan, Björn, Vincenti, Flavio, Snell, Paul, Mamelok, Richard D, Bouw, Rene M

“…The pharmacokinetics of mycophenolic acid (MPA) are complex, with large interindividual variability over time. There are also well documented interactions with…”
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Application of intracerebral microdialysis to study regional distribution kinetics of drugs in rat brain by Lange, Elizabeth C.M., Bouw, M. Rene, Mandema, Jaap W., Danhof, Meindert, Boer, Albertus G., Breimer, Douwe D.

“…1 The purpose of the present study was to determine whether intracerebral microdialysis can be used for the assessment of local differences in drug…”
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