Search Results - "Boutros, P C"

Risk Factors for Voriconazole Hepatotoxicity at 12 Weeks in Lung Transplant Recipients by Luong, M‐L., Hosseini‐Moghaddam, S. M., Singer, L. G., Chaparro, C., Azad, S., Lazar, N., Boutros, P. C., Keshavjee, S., Rotstein, C., Husain, S.

“…Voriconazole is commonly used for prophylaxis and treatment of invasive aspergillosis in lung transplant recipients. However, the use of voriconazole may at…”
Get full text

C-terminal region of teneurin-1 co-localizes with dystroglycan and modulates cytoskeletal organization through an extracellular signal-regulated kinase-dependent stathmin- and filamin A-mediated mechanism in hippocampal cells by Chand, D, Song, L, deLannoy, L, Barsyte-Lovejoy, D, Ackloo, S, Boutros, P.C, Evans, K, Belsham, D.D, Lovejoy, D.A

“…Highlights ► TCAP-1 co-localizes with β-dystroglycan in immortalized hippocampal cell culture. ► TCAP-1 induces ERK-dependent stathmin and filamin A…”
Get full text

Independent and functional validation of a multi-tumour-type proliferation signature by Starmans, M H W, Lieuwes, N G, Span, P N, Haider, S, Dubois, L, Nguyen, F, van Laarhoven, H W, Sweep, F C G J, Wouters, B G, Boutros, P C, Lambin, P

“…Background: Previously we demonstrated that an mRNA signature reflecting cellular proliferation had strong prognostic value. As clinical applicability of…”
Get full text

Unsupervised pattern recognition : An introduction to the whys and wherefores of clustering microarray data by BOUTROS, Paul C, OKEY, Allan B

“…Clustering has become an integral part of microarray data analysis and interpretation. The algorithmic basis of clustering -- the application of unsupervised…”
Get full text

How do changes in the mtDNA and mitochondrial dysfunction influence cancer and cancer therapy? Challenges, opportunities and models by van Gisbergen, M.W., Voets, A.M., Starmans, M.H.W., de Coo, I.F.M., Yadak, R., Hoffmann, R.F., Boutros, P.C., Smeets, H.J.M., Dubois, L., Lambin, P.

“…Several mutations in nuclear genes encoding for mitochondrial components have been associated with an increased cancer risk or are even causative, e.g…”
Get full text

Role of Nek2 on centrosome duplication and aneuploidy in breast cancer cells by Cappello, P, Blaser, H, Gorrini, C, Lin, D C C, Elia, A J, Wakeham, A, Haider, S, Boutros, P C, Mason, J M, Miller, N A, Youngson, B, Done, S J, Mak, T W

“…Breast cancer is the most common solid tumor and the second most common cause of death in women. Despite a large body of literature and progress in breast…”
Get full text

Establishment of four head and neck squamous cell carcinoma cell lines: importance of reference DNA for accurate genomic characterisation by Patel, K B, Prokopec, S, Barrett, J W, Mymryk, J S, Boutros, P C, Nichols, A C

“…There is significant interest in developing early passage cell lines with matched normal reference DNA to facilitate a precision medicine approach in assessing…”
Get more information

Multimodal Biomarkers That Predict the Presence of Gleason Pattern 4: Potential Impact for Active Surveillance by Berman, D M, Lee, A Y, Lesurf, R, Patel, P G, Ebrahimizadeh, W, Bayani, J, Lee, L A, Boufaied, N, Selvarajah, S, Jamaspishvili, T, Guérard, K-P, Dion, D, Kawashima, A, Clarke, G M, How, N, Jackson, C L, Scarlata, E, Siddiqui, K, Okello, J B A, Aprikian, A G, Moussa, M, Finelli, A, Chin, J, Brimo, F, Bauman, G, Loblaw, A, Venkateswaran, V, Buttyan, R, Chevalier, S, Thomson, A, Park, P C, Siemens, D R, Lapointe, J, Boutros, P C, Bartlett, J M S

“…Latent grade group ≥2 prostate cancer can impact the performance of active surveillance protocols. To date, molecular biomarkers for active surveillance have…”
Get full text

Pdxdc1 modulates prepulse inhibition of acoustic startle in the mouse by Feldcamp, L A, Boutros, P C, Raymond, R, Fletcher, P J, Nobrega, J N, Wong, A H C

“…Current antipsychotic medications used to treat schizophrenia all target the dopamine D2 receptor. Although these drugs have serious side effects and limited…”
Get full text

Toxicological implications of polymorphisms in receptors for xenobiotic chemicals: The case of the aryl hydrocarbon receptor by Okey, Allan B., Franc, Monique A., Moffat, Ivy D., Tijet, Nathalie, Boutros, Paul C., Korkalainen, Merja, Tuomisto, Jouko, Pohjanvirta, Raimo

“…Mechanistic toxicology has predominantly been focused on adverse effects that are caused by reactive metabolites or by reactive oxygen species. However, many…”
Get full text

combined frontal and maxillary sinus approach for repulsion of the third maxillary molar in a horse by Boutros, C.P, Koenig, J.B

“…The 3rd maxillary molar is a difficult tooth to remove by extraction or repulsion. A combined frontal and maxillary approach provides good exposure for…”
Get full text

Predicting human olfactory perception from chemical features of odor molecules by Keller, Andreas, Gerkin, Richard C., Guan, Yuanfang, Dhurandhar, Amit, Turu, Gabor, Szalai, Bence, Mainland, Joel D., Ihara, Yusuke, Yu, Chung Wen, Wolfinger, Russ, Vens, Celine, Schietgat, Leander, De Grave, Kurt, Norel, Raquel, Stolovitzky, Gustavo, Cecchi, Guillermo A., Vosshall, Leslie B., Meyer, Pablo

“…It is still not possible to predict whether a given molecule will have a perceived odor or what olfactory percept it will produce. We therefore organized the…”
Get full text

Gene Expression Profiling in a Model of d-Penicillamine-Induced Autoimmunity in the Brown Norway Rat:  Predictive Value of Early Signs of Danger by Séguin, Béatrice, Boutros, Paul C, Li, Xujian, Okey, Allan B, Uetrecht, Jack P

“…Idiosyncratic drug reactions (IDRs) cause significant morbidity and mortality. In an animal model of IDRs, 50−80% of Brown Norway rats exposed to…”
Get full text

Systematic evaluation of medium-throughput mRNA abundance platforms by Prokopec, Stephenie D, Watson, John D, Waggott, Daryl M, Smith, Ashley B, Wu, Alexander H, Okey, Allan B, Pohjanvirta, Raimo, Boutros, Paul C

“…Profiling of mRNA abundances with high-throughput platforms such as microarrays and RNA-seq has become an important tool in both basic and biomedical research…”
Get full text

Anti-nucleosome antibodies outperform traditional biomarkers as longitudinal indicators of disease activity in systemic lupus erythematosus by Li, Timothy, Prokopec, Stephenie D, Morrison, Stacey, Lou, Wendy, Reich, Heather, Gladman, Dafna, Urowitz, Murray, Scholey, James, Fortin, Paul R, Boutros, Paul C, Wither, Joan, Landolt-Marticorena, Carolina

“…The aim of this study was to determine whether anti-nucleosome antibodies function as activity-specific biomarkers in SLE. Fifty-one patients were recruited…”
Get full text

Association of CT antigen expression and survival in stage III melanoma by Turner, N. H., John, T., Deb, S., Campbell, A. M., Azad, A., Boutros, P. C., Chen, Y., Cebon, J. S.

“…Abstract only…”
Get full text

NY-ESO-1 as a predictive marker for neoadjuvant chemotherapy in stage IIIa non-small cell lung cancer (NSCLC) by John, T., Chen, Y., Starmans, M. H., Walkiewicz, M., Russell, P., Azad, A., Deb, S., Altorki, N. K., Boutros, P. C., Mitchell, P., Cebon, J. S.

“…Abstract only…”
Get full text

Aryl hydrocarbon receptor regulates distinct dioxin-dependent and dioxin-independent gene batteries by Tijet, Nathalie, Boutros, Paul C, Moffat, Ivy D, Okey, Allan B, Tuomisto, Jouko, Pohjanvirta, Raimo

“…Conventional biochemical and molecular techniques identified previously several genes whose expression is regulated by the aryl hydrocarbon receptor (AHR). We…”
Get more information

Translating a Prognostic DNA Genomic Classifier into the Clinic: Retrospective Validation in 563 Localized Prostate Tumors by Lalonde, Emilie, Alkallas, Rached, Chua, Melvin Lee Kiang, Fraser, Michael, Haider, Syed, Meng, Alice, Zheng, Junyan, Yao, Cindy Q, Picard, Valerie, Orain, Michele, Hovington, Helène, Murgic, Jure, Berlin, Alejandro, Lacombe, Louis, Bergeron, Alain, Fradet, Yves, Têtu, Bernard, Lindberg, Johan, Egevad, Lars, Grönberg, Henrik, Ross-Adams, Helen, Lamb, Alastair D, Halim, Silvia, Dunning, Mark J, Neal, David E, Pintilie, Melania, van der Kwast, Theodorus, Bristow, Robert G, Boutros, Paul C

“…Abstract Background Localized prostate cancer is clinically heterogeneous, despite clinical risk groups that represent relative prostate cancer-specific…”
Get full text

Re: Gene Expression–Based Prognostic Signatures in Lung Cancer: Ready for Clinical Use? by Boutros, Paul C., Pintilie, Melania, John, Thomas, Starmans, Maud H. W., Der, Sandy D., Shepherd, Frances A., Tsao, Ming-Sound, Jurisica, Igor

Get full text