Search Results - "Boutouyrie‐Dumont, Bruno"

Secukinumab Treatment Does Not Alter the Pharmacokinetics of the Cytochrome P450 3A4 Substrate Midazolam in Patients With Moderate to Severe Psoriasis by Bruin, Gerard, Hasselberg, Anke, Koroleva, Irina, Milojevic, Julie, Calonder, Claudio, Soon, Rachel, Woessner, Ralph, Pariser, David M., Boutouyrie‐Dumont, Bruno

“…This open‐label disease‐drug–drug interaction study assessed whether blockade of the interleukin (IL)‐17A pathway by secukinumab and subsequent downregulation…”
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Comparison of pharmacokinetics, safety and tolerability of secukinumab administered subcutaneously using different delivery systems in healthy volunteers and in psoriasis patients by Bruin, Gerard, Hockey, Hans‐Ulrich P., La Stella, Phillip, Sigurgeirsson, Bárdur, Fu, Rong, Patekar, Manmath, Charef, Pascal, Woessner, Ralph, Boutouyrie‐Dumont, Bruno

“…Aims The aim of the study was to compare the pharmacokinetics (PK), safety and tolerability of secukinumab with different devices for subcutaneous (s.c.)…”
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Poster #226 SAFETY, TOLERABILITY AND PHARMACOKINETICS OF RG1678, A NOVEL GLYCINE REUPTAKE INHIBITOR, AFTER MULTIPLE DOSES IN HEALTHY VOLUNTEERS by Martin-Facklam, Meret, Patat, Alain, Hofmann, Carsten, Boetsch, Christophe, Banken, Ludger, Biedinger, Ursula, Boutouyrie-Dumont, Bruno

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Effects of the glycine reuptake inhibitors bitopertin and RG7118 on glycine in cerebrospinal fluid: results of two proofs of mechanism studies in healthy volunteers by Hofmann, Carsten, Pizzagalli, Flavia, Boetsch, Christophe, Alberati, Daniela, Ereshefsky, Larry, Jhee, Stanford, Patat, Alain, Boutouyrie-Dumont, Bruno, Martin-Facklam, Meret

“…Rationale Hypofunction of NMDA receptors has been implicated in neuropsychiatric disorders including schizophrenia. NMDA receptor neurotransmission can be…”
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An aide memoire for model-based drug development--a new key for the interpretation of the erythromycin breath test--therapeutic index as a biomarker for smart drug development by Boutouyrie-Dumont, Bruno

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Application of clinical and molecular profiling data to improve patient outcomes in psoriatic arthritis by FitzGerald, Oliver, Behrens, Frank, Barton, Anne, Bertheussen, Heidi, Boutouyrie-Dumont, Bruno, Coates, Laura, Davies, Owen, de Wit, Maarten, Fagni, Filippo, Goodyear, Carl S., Gurke, Robert, Hahnefeld, Lisa, Huppertz, Christine, Ioannidis, Vassilios, Ibberson, Mark, Katz, Arnon, Klippstein, Maximilian, Koehm, Michaela, Korish, Shimon, Mackay, Sina, Martin, David A., O’Sullivan, Denis, Patel, Khadijah, Rueping, Stefan, Schett, Georg, Scholich, Klaus, Schwenk, Jochen M., Siebert, Stefan, Simon, David, Vivekanantham, Arani, Pennington, Stephen R.

“…Achieving a good outcome for a person with Psoriatic Arthritis (PsA) is made difficult by late diagnosis, heterogenous clinical disease expression and in many…”
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Poster #209 CENTRAL GLYCINE INCREASE IN RATS, MONKEYS AND HEALTHY VOLUNTEERS AFTER TWO GLYCINE REUPTAKE INHIBITORS, RG1678 AND RG7118 by Pizzagalli, Flavia, Martin-Facklam, Meret, Hofmann, Carsten, Boetsch, Christophe, Ereshefsky, Larry, Patat, Alain, Boutouyrie-Dumont, Bruno, Wettstein, Joseph G, Alberati, Daniela

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