MEASUREMENT OF AORTIC STIFFNESS BY LASER DOPPLER VIBROMETRY: THE CARDIS STUDY

OBJECTIVE:The CARDIS consortium developed a non-contact device for measuring carotid to femoral pulse wave velocity (cfPWV) using a laser doppler vibrometer (LDV). CARDIS-LDV measures skin vibrations induced by large artery pulses. From pulse waveforms, transit time (TT) can be calculated. The aim o...

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Bibliographic Details
Published in:	Journal of hypertension Vol. 37 Suppl 1; p. e88
Main Authors:	Marais, L, Khettab, H, Li, Y, Segers, P, Baets, R, Reesink, K, Aasmul, S, De Melis, M, Boutouyrie, Pi
Format:	Journal Article
Language:	English
Published:	Copyright Wolters Kluwer Health, Inc. All rights reserved 01-07-2019
Online Access:	Get full text
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Summary:	OBJECTIVE:The CARDIS consortium developed a non-contact device for measuring carotid to femoral pulse wave velocity (cfPWV) using a laser doppler vibrometer (LDV). CARDIS-LDV measures skin vibrations induced by large artery pulses. From pulse waveforms, transit time (TT) can be calculated. The aim of the study was to compare LDV-cfPWV with the reference cfPWV measured by applanation tonometry (Sphygmocor).(Figure is included in full-text article.) DESIGN AND METHOD:100 patients with mild to stage 3 hypertension, controlled or not, were tested. LDV-cfPWV was measured 4 times by applying reflective tapes on the carotid and femoral arteries. TT was measured at the foot of the wave from the maximum of 2nd derivative using in-house algorithms not requiring ECG, and compared to Sphygmocor (3 acquisitions). RESULTS:LDV-cfPWV was obtained in 100% of patients. Mean age was 47 ± 19 (range 19–85). Hypertensives were well controlled (119/65 mmHg). Mean value of LDV-cfPWV was 6.9 ± 1.7 m/s, compared to 7.5 ± 1.7 m/s with Sphygmocor, bias 0.65 ± 1.27, R value 0.72 (see Figure), which qualifies agreement as acceptable according to the guidelines from the ARTERY Society (Wilkinson et al., Artery Research 2010). Reproducibility was good with a median coefficient of variation of 5.6%. LDV-cfPWV has similar association with age and blood pressure than tonometry (r = 0.68, p < 0.001 and r = 0.44, p < 0.001, respectively). CONCLUSIONS:Non-contact measurement of pulse wave velocity by laser doppler vibrometry is feasible, highly acceptable by patients and provides acceptable agreement with reference technique.
ISSN:	0263-6352 1473-5598
DOI:	10.1097/01.hjh.0000570292.62996.dd