Search Results - "Boutin, H."

Early changes in extracellular matrix in Alzheimer's disease by Lepelletier, F.‐X., Mann, D. M. A., Robinson, A. C., Pinteaux, E., Boutin, H.

“…Aims Although changes in extracellular matrix (ECM) scaffold have been reported previously in Alzheimer's disease (AD) compared to normal ageing, it is not…”
Get full text

Measurement of Protein Synthesis Rate in Rat by [11C]Leucine PET Imaging: Application to the TgF344-AD Model of Alzheimer’s Disease by Bochicchio, D., Christie, L., Lawrence, C. B., Herholz, K., Parker, C. A., Hinz, R., Boutin, H.

“…Long-term memory requires stable protein synthesis and is altered in Alzheimer’s disease (AD). This study aimed to implement a method to measure the cerebral…”
Get full text

Role of IL-1α and IL-1β in Ischemic Brain Damage by Boutin, H., LeFeuvre, R. A., Horai, R., Asano, M., Iwakura, Y., Rothwell, N. J.

“…The cytokine interleukin-1 (IL-1) has been strongly implicated in the pathogenesis of ischemic brain damage. Evidence to date suggests that the major form of…”
Get full text

Development of a method for the preparation of zirconium-89 radiolabelled chitosan nanoparticles as an application for leukocyte trafficking with positron emission tomography by Fairclough, M, Ellis, B, Boutin, H, Jones, A K P, McMahon, A, Alzabin, S, Gennari, A, Prenant, C

“…Positron Emission Tomography is an attractive imaging modality for monitoring the migration of cells to pathological tissue. We evaluated a new method for…”
Get full text

Biodistribution, pharmacokinetics and metabolism of interleukin‐1 receptor antagonist (IL‐1RA) using [18F]‐IL1RA and PET imaging in rats by Cawthorne, C, Prenant, C, Smigova, A, Julyan, P, Maroy, R, Herholz, K, Rothwell, N, Boutin, H

“…BACKGROUND AND PURPOSE Positron emission tomography (PET) has the potential to improve our understanding of the preclinical pharmacokinetics and metabolism of…”
Get full text

A new technique for the radiolabelling of mixed leukocytes with zirconium-89 for inflammation imaging with positron emission tomography by Fairclough, M., Prenant, C., Ellis, B., Boutin, H., McMahon, A., Brown, G., Locatelli, P., Jones, A.K.P.

“…Mixed leukocyte (white blood cells [WBCs]) trafficking using positron emission tomography (PET) is receiving growing interest to diagnose and monitor…”
Get full text

Interleukin-1 in the brain: mechanisms of action in acute neurodegeneration by Patel, H C, Boutin, H, Allan, S M

“…Interleukin-1 (IL-1) exerts a number of diverse actions in the brain, and it is currently well accepted that it contributes to experimentally induced…”
Get full text

Contribution of Interleukin-1 Receptor Accessory Protein b to Interleukin-1 Actions in Neuronal Cells by Nguyen, L., Rothwell, N.J., Pinteaux, E., Boutin, H.

“…Interleukin (IL)-1 is an important neuroimmunomodulator and a key mediator of inflammation during brain disorders. It acts on neuronal and glial cells via…”
Get full text

Radiolabeling with fluorine-18 of a protein, interleukin-1 receptor antagonist by Prenant, C., Cawthorne, C., Fairclough, M., Rothwell, N., Boutin, H.

“…IL-1RA is a naturally occurring antagonist of the pro-inflammatory cytokine interleukin-1 (IL-1) with high therapeutic promise, but its pharmacokinetic remains…”
Get full text

Improved synthesis of the peripheral benzodiazepine receptor ligand [ 11C]DPA-713 using [ 11C]methyl triflate by Thominiaux, C., Dollé, F., James, M.L., Bramoullé, Y., Boutin, H., Besret, L., Grégoire, M.-C., Valette, H., Bottlaender, M., Tavitian, B., Hantraye, Ph, Selleri, S., Kassiou, M.

“…Recently, the pyrazolopyrimidine, [ 11C] N,N-Diethyl-2-[2-(4-methoxyphenyl)-5,7-dimethylpyrazolo[1,5- a]pyrimidin-3-yl]acetamide (DPA-713) has been reported as…”
Get full text

Radiosynthesis of 2-[6-chloro-2-(4-iodophenyl)imidazo[1,2-a]pyridin-3-yl]-N-ethyl-N-[11C]methyl-acetamide, [11C]CLINME, a novel radioligand for imaging the peripheral benzodiazepine receptors with PET by Thominiaux, C., Mattner, F., Greguric, I., Boutin, H., Chauveau, F., Kuhnast, B., Grégoire, M.-C., Loc′h, C., Valette, H., Bottlaender, M., Hantraye, Ph, Tavitian, B., Katsifis, A., Dollé, F.

“…Recently, a new 2‐(iodophenyl)imidazo[1,2‐a]pyridineacetamide series has been developed as iodine‐123‐labelled radioligands for imaging the peripheral…”
Get full text

Interleukin-1 in the Brain by PATEL, H. C., BOUTIN, H., ALLAN, S. M.

“…: Interleukin‐1 (IL‐1) exerts a number of diverse actions in the brain, and it is currently well accepted that it contributes to experimentally induced…”
Get full text

Understand and control your asthma by Boutin, Hélène, Boulet, Louis-Philippe

“…Asthma is one of the most common respiratory diseases, affecting between twelve and fifteen million people in North America. Although asthma can often be…”
Get full text

Targeted gene transfer to hepatocellular carcinoma cells in vitro using a novel monoclonal antibody−based gene delivery system by Mohr, Leonhard, Schauer, Julia I., Boutin, Raymond H., Moradpour, Darius, Wands, Jack R.

“…Gene therapy approaches for the treatment of malignant tumors will require high‐level expression of therapeutic genes in tumors compared with normal tissues…”
Get full text

Nuclear imaging of neuroinflammation: a comprehensive review of [11C]PK11195 challengers by Chauveau, Fabien, Boutin, Hervé, Van Camp, Nadja, Dollé, Frédéric, Tavitian, Bertrand

“…Neurodegenerative, inflammatory and neoplastic brain disorders involve neuroinflammatory reactions, and a biomarker of neuroinflammation would be useful for…”
Get full text

Urinary tract dilatation in utero: classification and clinical applications by Grignon, A, Filion, R, Filiatrault, D, Robitaille, P, Homsy, Y, Boutin, H, Leblond, R

“…A morphologic classification of in utero urinary tract dilatation is presented. Ninety-two hydronephrotic fetal kidneys diagnosed with ultrasound were graded…”
Get more information

Influence of asthma education on asthma severity, quality of life and environmental control by Côté, J, Cartier, A, Robichaud, P, Boutin, H, Malo, J L, Rouleau, M, Boulet, L P

“…Several studies have examined the influence of asthma education, focusing mainly on the use of health services. To assess the influence of an asthma education…”
Get full text

alpha.-Amino acid derivatives as chiral educts for asymmetric products. Synthesis of sphingosine from .alpha.'-amino-.alpha.,.beta.-ynones by Boutin, Raymond H, Rapoport, Henry

Get full text

Efficient Gene Transfer into Mammalian Cells with Cholesteryl-Spermidine by Moradpour, Darius, Schauer, Julia I., Zurawski, Jr, Vincent R., Wands, Jack R., Boutin, Raymond H.

“…The naturally occurring polyamine spermidine was covalently conjugated with cholesterol, resulting in a novel cationic compound that mediates efficient gene…”
Get full text

alpha.-Amino acids as chiral educts for asymmetric products. The synthesis of .alpha.'-amino-.alpha.,.beta.-ynones by Cupps, Thomas L, Boutin, Raymond H, Rapoport, Henry

Get full text